Low energy shock wave‐delivered intravesical botulinum neurotoxin‐A potentiates antioxidant genes and inhibits proinflammatory cytokines in rat model of overactive bladder

2020 ◽  
Vol 39 (8) ◽  
pp. 2447-2454
Author(s):  
Mohammed Nageib ◽  
Mohamed H. Zahran ◽  
Ahmed S. El‐Hefnawy ◽  
Nashwa Barakat ◽  
Amira Awadalla ◽  
...  
Keyword(s):  
Shock Wave ◽  
Overactive Bladder ◽  
Proinflammatory Cytokines ◽  
Rat Model ◽  
Botulinum Neurotoxin ◽  
Low Energy ◽  
Botulinum Neurotoxin A ◽  
Antioxidant Genes

scholarly journals Low-Energy Extracorporeal Shock Wave Therapy Ameliorates Kidney Function in Diabetic Nephropathy

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Chang-Chun Hsiao ◽  
Wei-Han Huang ◽  
Kuang-Hung Cheng ◽  
Chien-Te Lee
Keyword(s):  
Oxidative Stress ◽  
Shock Wave ◽  
Diabetic Nephropathy ◽  
Rat Model ◽  
Renal Fibrosis ◽  
Tissue Repair ◽  
Extracorporeal Shock Wave Therapy ◽  
Low Energy ◽  
Shock Wave Therapy ◽  
Extracorporeal Shock Wave

Background. Diabetic nephropathy is the most common cause of end-stage renal disease. Traditional therapy for diabetic nephropathy has focused on supportive treatment, and there is no significant effective therapy. We investigated the effect of low-energy extracorporeal shock wave therapy on a diabetic nephropathy rat model. Methods. Streptozotocin-induced diabetic nephropathy rats were treated with six sessions of low-energy extracorporeal shock wave therapy (weekly for six consecutive weeks) or left untreated. We assessed urinary creatinine and albumin, glomerular volume, renal fibrosis, podocyte number, renal inflammation, oxidative stress, and tissue repair markers (SDF-1 and VEGF) six weeks after the completion of treatment. Results. The six-week low-energy extracorporeal shock wave therapy regimen decreased urinary albumin excretion as well as reduced glomerular hypertrophy and renal fibrosis in the rat model of diabetic nephropathy. Moreover, low-energy extracorporeal shock wave therapy increased podocyte number in diabetic nephropathy rats. This was likely primarily attributed to the fact that low-energy extracorporeal shock wave therapy reduced renal inflammation and oxidative stress as well as increased tissue repair potency and cell proliferation. Conclusions. Low-energy extracorporeal shock wave therapy preserved kidney function in diabetic nephropathy. Low-energy extracorporeal shock wave therapy may serve as a novel noninvasive and effective treatment of diabetic nephropathy.

Effect of low‐energy shock wave therapy on intravesical epirubicin delivery in a rat model of bladder cancer

2020 ◽  
Vol 127 (1) ◽  
pp. 80-89 ◽  
Author(s):  
Ahmed Elkashef ◽  
Nashwa Barakat ◽  
Sherry M. Khater ◽  
Amira Awadalla ◽  
Fathallah Belal ◽  
...  
Keyword(s):  
Shock Wave ◽  
Bladder Cancer ◽  
Rat Model ◽  
Low Energy ◽  
Shock Wave Therapy

scholarly journals Botulinum Toxin Use in the Lower Urinary Tract

2007 ◽  
Vol 7 ◽  
pp. 808-817
Author(s):  
Shelby N. Morrisroe ◽  
Michael B. Chancellor
Keyword(s):  
Botulinum Toxin ◽  
Urinary Tract ◽  
Overactive Bladder ◽  
Lower Urinary Tract ◽  
Botulinum Neurotoxin ◽  
Botulinum Toxins ◽  
Muscle Paralysis ◽  
Botulinum Neurotoxin A ◽  
Beneficial Effects ◽  
Lower Urinary

Botulinum toxins are well known for their ability to disrupt neurotransmission and cause muscle paralysis. Recently, urologists have discovered their beneficial effects in patients with neurogenic and overactive bladder conditions. This review is intended to provide a quick overview for urologists of the structure, function, and clinical uses of botulinum neurotoxin A in the lower urinary tract.

scholarly journals Cost-Effectiveness of Sacral Neuromodulation Compared to Botulinum Neurotoxin A or Continued Medical Management in Refractory Overactive Bladder

2011 ◽  
Vol 14 (2) ◽  
pp. 219-228 ◽  
Author(s):  
Salvador Arlandis ◽  
David Castro ◽  
Carlos Errando ◽  
Eldiberto Fernández ◽  
Miguel Jiménez ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Overactive Bladder ◽  
Medical Management ◽  
Botulinum Neurotoxin ◽  
Sacral Neuromodulation ◽  
Botulinum Neurotoxin A

160 Defocused Low-energy Shock Wave can Stimulate Penile Tissues to Produce more Energy for Growth and Proliferation in a DMED Rat Model

2018 ◽  
Vol 15 (2) ◽  
pp. S46
Author(s):  
W.J. Bae ◽  
G.Q. Zhu ◽  
S.W. Choi ◽  
H.C. Jeong ◽  
F. Bashraheel ◽  
...  
Keyword(s):  
Shock Wave ◽  
Rat Model ◽  
Low Energy

Intranasal Delivery of Botulinum Neurotoxin A Protects against Hippocampal Neuron Death in the Lithium-Pilocarpine Rat Model

2019 ◽  
Vol 44 (5) ◽  
pp. 1262-1268 ◽  
Author(s):  
Zhi Huang ◽  
Yajun Lian ◽  
Yuan Chen ◽  
Shuang Li ◽  
Haifeng Zhang ◽  
...  
Keyword(s):  
Rat Model ◽  
Hippocampal Neuron ◽  
Botulinum Neurotoxin ◽  
Intranasal Delivery ◽  
Neuron Death ◽  
Botulinum Neurotoxin A

scholarly journals AB098. Defocused low-energy shock wave can stimulate penile tissues to produce more energy for growth and proliferation in a DMED rat model

2017 ◽  
Vol 6 (S3) ◽  
pp. AB098-AB098
Author(s):  
Woong Jin Bae ◽  
Guan Qun Zhu ◽  
Sae Woong Choi ◽  
Hyun Cheol Jeong ◽  
Fahad Bashraheel ◽  
...  
Keyword(s):  
Shock Wave ◽  
Rat Model ◽  
Low Energy

Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

2018 ◽  
Vol 34 (4) ◽  
pp. 720-727 ◽  
Author(s):  
Keng‐Liang Wu ◽  
Yi‐Chun Chiu ◽  
Chih‐Chien Yao ◽  
Cheng‐En Tsai ◽  
Ming‐Luen Hu ◽  
...  
Keyword(s):  
Shock Wave ◽  
Rat Model ◽  
Low Energy ◽  
Diabetic Gastroparesis
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