Gastrointestinal: Endoscopic submucosal dissection for rectal cancer with dysplasia in ulcerative colitis

2016 ◽  
Vol 31 (11) ◽  
pp. 1797-1797
Author(s):  
K Kawasaki ◽  
S Yanai ◽  
M Eizuka ◽  
Y Toya ◽  
S Nakamura ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Rectal Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection

scholarly journals Su1688 COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION FOR PATIENTS WITH ULCERATIVE COLITIS

2018 ◽  
Vol 87 (6) ◽  
pp. AB369-AB370
Author(s):  
Ryosuke Kobayashi ◽  
Kingo Hirasawa ◽  
Chiko Sato ◽  
Masafumi Nishio ◽  
Tsuyoshi Ogashiwa ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
Colorectal Endoscopic Submucosal Dissection

The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis

2018 ◽  
Vol 87 (4) ◽  
pp. 1079-1084 ◽  
Author(s):  
Satoshi Kinoshita ◽  
Toshio Uraoka ◽  
Toshihiro Nishizawa ◽  
Makoto Naganuma ◽  
Yasushi Iwao ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
Colorectal Endoscopic Submucosal Dissection

scholarly journals SYSTEMATIC REVIEW AND METAANALYSIS OF TRANSANAL ENDOSCOPIC MICROSURGERY VERSUS ENDOSCOPIC SUBMUCOSAL DISSECTION FOR RECTAL ADENOMAS AND EARLY RECTAL CANCER

2019 ◽  
Vol 18 (2) ◽  
pp. 7-20
Author(s):  
S. V. Chernyshov ◽  
M. A. Tarasov ◽  
M. A. Nagudov ◽  
D. A. Mtvralashvili ◽  
A. Likutov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Rectal Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Transanal Endoscopic Microsurgery ◽  
Meta Analysis ◽  
Early Colorectal Cancer ◽  
Early Rectal Cancer ◽  
Submucosal Dissection ◽  
Endoscopic Microsurgery

AIM: transanal endomicrosurgery (TEM) is the standard for organ-preserving treatment of patients with large adenomas and early rectal cancer. The advantage of TEM in comparison with other transanal methods of treatment of rectal tumors is the low frequency of R1 resections and fragmentation, which procudes a low level of local recurrences. Endoscopic submucosal dissection (ESD) is a new technology for superficial rectum tumors. This systematic review and meta-analysis compared safety and efficacy of ESD vs TEM for large adenoma and early colorectal cancer.PATIENTS AND METHODS: a literature search and meta-analysis of the data was carried out in accordance with the English-language Medline database without restrictions on the publication date (end December 18, 2018) according to keywords: «endoscopic submucosal dissection», «esd», «endoscopic dissection», «tem», «tamis», «transanal endoscopic microsurgery», «transanal resection», «teo», «transanal endoscopic microsurgical excision». The systematic review includes all papers on the comparison of TEM and ESD for large adenomas and early rectal cancer. Statistical data processing was performed using Review Manager 5.3.RESULTS: four retrospective comparative studies were included in the analysis (215 patients). Groups were homogenous in the number of tumors (Odds ratio [OR]=1,19; 95% confidence interval [CI] 0.23-6.16) and size (p=0.55). The intraoperative morbidity included bleeding (p=0.54) and rectal perforation (p=0.32) was homogenous as well. The operation time in the ESD group was significantly longer by 32 minutes than TEM (OR=32.5;95% CI 17,7-47.4; p<0.0001). Postoperative stay was higher than in 1.6 times after TEM (OR=16.1; 95% CI 1.5-30.1; p=0.03). The antibiotics use after surgery was not significantly different in both groups (p=0.33). The en-bloc resections (p=0.66) and the rate of R1 resections (p=0.74) were not significantly different in both groups. The local recurrence rate was homogenous (p=0.95).CONCLUSIONS: the ESD and TEM procedures are safe and effective techniques for local excision of adenomas and early colorectal cancer, but a randomized study is needed to prove the results.

scholarly journals P656 Clinical implications of endoscopic submucosal dissection in management of patients with ulcerative colitis-associated dysplasia

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S540-S541
Author(s):  
T Sakurai ◽  
R Nezu ◽  
A Okada ◽  
Y Komeda ◽  
T Nagai ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Tp53 Mutation ◽  
Magnifying Endoscopy ◽  
Clinical Implications ◽  
Low Grade ◽  
Submucosal Dissection ◽  
Metachronous Colorectal Cancer ◽  
Gene Mutation Analysis

Abstract Background Colectomy has been recommended for patients presenting ulcerative colitis (UC)-associated dysplasia because of the risk of metachronous recurrence. However, it has been recently proposed that endoscopic submucosal dissection (ESD) of dysplasia, combined with subsequent surveillance, may contribute to avoiding colectomy. This study assessed clinical implications of ESD in UC-associated dysplasia. Methods We investigated 30 lesions (27 patients) of UC-associated dysplasia/cancer treated with ESD and surgery (15 ESD and 16 surgery) including a patient who underwent surgery following ESD. Among them, paraffin-embedded tissues of 15 lesions (6 cancers, 7 high-grade dysplasia: HGDs, 2 low-grade dysplasia: LGDs) and 11 surrounding mucosae were available and gene mutation analysis was performed. Indications for ESD were determined according to the criteria applied for sporadic colorectal neoplasms that are based on magnifying endoscopy. Results The median follow-up duration was 40 months. Three out of 27 patients (11%) developed metastasis. Although no serious complications, local recurrence, or metastasis occurred in 13 patients undergoing ESD, one out of them (7.7%) had metachronous colorectal cancer 3 years after ESD in the rectum, where TP53 mutation and diffuse p53 staining was found at non-dysplastic mucosae. Based on magnifying endoscopy, we underestimated the invasion depth in two cases: in a case of deeply submucosal invasive mucinous cancer, endoscopic ultrasonography exhibited thickening of the submucosal layer exclusively at the lesion. Conclusion The proposed indication for ESD in UC-associated dysplasia is that a lesion is well-demarcated and surrounding mucosa is not actively inflamed and does not exhibit diffuse p53 staining. ESD would contribute to advances in the management of UC-associated dysplasia.

scholarly journals Endoscopic submucosal dissection for remnant rectal neoplasm after ileal pouch-anal anastomosis for ulcerative colitis

Endoscopy ◽  
2019 ◽  
Vol 51 (12) ◽  
pp. E406-E407
Author(s):  
Shunsuke Yoshii ◽  
Shinichiro Shinzaki ◽  
Yoshito Hayashi ◽  
Yoshiki Tsujii ◽  
Munehiro Ashida ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Ileal Pouch ◽  
Rectal Neoplasm ◽  
Ileal Pouch Anal Anastomosis ◽  
Submucosal Dissection ◽  
Anal Anastomosis

Outcomes of ulcerative colitis‐associated dysplasia patients referred for potential endoscopic submucosal dissection

2019 ◽  
Vol 34 (9) ◽  
pp. 1581-1589 ◽  
Author(s):  
Dong‐Hoon Yang ◽  
Jihun Kim ◽  
Eun Mi Song ◽  
Kiju Chang ◽  
Sun‐Ho Lee ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection
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