Outcomes of ulcerative colitis‐associated dysplasia patients referred for potential endoscopic submucosal dissection

2019 ◽  
Vol 34 (9) ◽  
pp. 1581-1589 ◽  
Author(s):  
Dong‐Hoon Yang ◽  
Jihun Kim ◽  
Eun Mi Song ◽  
Kiju Chang ◽  
Sun‐Ho Lee ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection

scholarly journals Su1688 COLORECTAL ENDOSCOPIC SUBMUCOSAL DISSECTION FOR PATIENTS WITH ULCERATIVE COLITIS

2018 ◽  
Vol 87 (6) ◽  
pp. AB369-AB370
Author(s):  
Ryosuke Kobayashi ◽  
Kingo Hirasawa ◽  
Chiko Sato ◽  
Masafumi Nishio ◽  
Tsuyoshi Ogashiwa ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
Colorectal Endoscopic Submucosal Dissection

The role of colorectal endoscopic submucosal dissection in patients with ulcerative colitis

2018 ◽  
Vol 87 (4) ◽  
pp. 1079-1084 ◽  
Author(s):  
Satoshi Kinoshita ◽  
Toshio Uraoka ◽  
Toshihiro Nishizawa ◽  
Makoto Naganuma ◽  
Yasushi Iwao ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection ◽  
Colorectal Endoscopic Submucosal Dissection

scholarly journals P656 Clinical implications of endoscopic submucosal dissection in management of patients with ulcerative colitis-associated dysplasia

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S540-S541
Author(s):  
T Sakurai ◽  
R Nezu ◽  
A Okada ◽  
Y Komeda ◽  
T Nagai ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Tp53 Mutation ◽  
Magnifying Endoscopy ◽  
Clinical Implications ◽  
Low Grade ◽  
Submucosal Dissection ◽  
Metachronous Colorectal Cancer ◽  
Gene Mutation Analysis

Abstract Background Colectomy has been recommended for patients presenting ulcerative colitis (UC)-associated dysplasia because of the risk of metachronous recurrence. However, it has been recently proposed that endoscopic submucosal dissection (ESD) of dysplasia, combined with subsequent surveillance, may contribute to avoiding colectomy. This study assessed clinical implications of ESD in UC-associated dysplasia. Methods We investigated 30 lesions (27 patients) of UC-associated dysplasia/cancer treated with ESD and surgery (15 ESD and 16 surgery) including a patient who underwent surgery following ESD. Among them, paraffin-embedded tissues of 15 lesions (6 cancers, 7 high-grade dysplasia: HGDs, 2 low-grade dysplasia: LGDs) and 11 surrounding mucosae were available and gene mutation analysis was performed. Indications for ESD were determined according to the criteria applied for sporadic colorectal neoplasms that are based on magnifying endoscopy. Results The median follow-up duration was 40 months. Three out of 27 patients (11%) developed metastasis. Although no serious complications, local recurrence, or metastasis occurred in 13 patients undergoing ESD, one out of them (7.7%) had metachronous colorectal cancer 3 years after ESD in the rectum, where TP53 mutation and diffuse p53 staining was found at non-dysplastic mucosae. Based on magnifying endoscopy, we underestimated the invasion depth in two cases: in a case of deeply submucosal invasive mucinous cancer, endoscopic ultrasonography exhibited thickening of the submucosal layer exclusively at the lesion. Conclusion The proposed indication for ESD in UC-associated dysplasia is that a lesion is well-demarcated and surrounding mucosa is not actively inflamed and does not exhibit diffuse p53 staining. ESD would contribute to advances in the management of UC-associated dysplasia.

scholarly journals Endoscopic submucosal dissection for remnant rectal neoplasm after ileal pouch-anal anastomosis for ulcerative colitis

Endoscopy ◽  
2019 ◽  
Vol 51 (12) ◽  
pp. E406-E407
Author(s):  
Shunsuke Yoshii ◽  
Shinichiro Shinzaki ◽  
Yoshito Hayashi ◽  
Yoshiki Tsujii ◽  
Munehiro Ashida ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Ileal Pouch ◽  
Rectal Neoplasm ◽  
Ileal Pouch Anal Anastomosis ◽  
Submucosal Dissection ◽  
Anal Anastomosis

scholarly journals Endoscopic Submucosal Dissection in Patients with Ulcerative Colitis

Digestion ◽  
2018 ◽  
Vol 99 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Satoshi Kinoshita ◽  
Toshihiro Nishizawa ◽  
Naohisa Yahagi ◽  
Toshio Uraoka
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection

P.21.2 ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) OF DYSPLASTIC LESIONS IN LONG-STANDING ULCERATIVE COLITIS

2014 ◽  
Vol 46 ◽  
pp. S135
Author(s):  
F. Iacopini ◽  
C. Grossi ◽  
P. Rigato ◽  
G. Costamagna ◽  
T. Matsuda ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Dissection

715 Large Non-Polypoid Superficial Neoplasms in Ulcerative Colitis: Curative Resection by Endoscopic Submucosal Dissection

2015 ◽  
Vol 81 (5) ◽  
pp. AB164
Author(s):  
Federico Iacopini ◽  
Yutaka Saito ◽  
Masayoshi Yamada ◽  
Guido Costamagna ◽  
Takuji Gotoda ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Endoscopic Submucosal Dissection ◽  
Curative Resection ◽  
Submucosal Dissection
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