Hepatology: Pancreatic lymphoepithelial cyst mimicking mucinous cystic neoplasm

2015 ◽  
Vol 30 (2) ◽  
pp. 235-235 ◽  
Author(s):  
K Fujita ◽  
M Fujimoto ◽  
H Terajima ◽  
S Yazumi
2016 ◽  
Vol 25 (2) ◽  
pp. 239-242 ◽  
Author(s):  
Hiroyuki Matsubayashi ◽  
Yoshiko Aikawa ◽  
Teiichi Sugiura ◽  
Keiko Sasaki ◽  
Kinichi Hotta ◽  
...  

A lymphoepithelial cyst (LEC) is a rare pancreatic lesion, histologically showing squamous epithelia, dense lymphoid tissues, and a keratin substance. Cross-section images of the pancreatic LEC typically show a well demarcated unilocular or multilocular cyst without a solid component. Here we report a rare case of pancreatic LEC in which multiple floating ball-like components were depicted via endoscopic ultrasound. The ball-like components were also depicted by various imaging methods such as computed tomography (CT) showing low-density components, T1-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) showing high-intensity components, and T2-weighted MRI showing low-intensity components. The ball-like components in all images were not well enhanced. Laparotomic cyst resection was performed, and the surgical material revealed keratin balls inside the pancreatic LEC. Keratin components of a pancreatic LEC can take a liquid, sludge, or solid form. Clinicians must be aware of the variations in imaging to facilitate the differentiation and management of pancreatic cystic lesions. Abbreviations: CA 19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; DWI: diffusion-weighted image; LEC: lymphoepithelial cyst; IPMN: intraductal papillary neoplasm; MCN: mucinous cystic neoplasm.


Choonpa Igaku ◽  
2011 ◽  
Vol 38 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Junko FUKUDA ◽  
Sachiko TANAKA ◽  
Miho NAKAO ◽  
Eri UEDA ◽  
Reiko SUZUKI ◽  
...  

2020 ◽  
pp. 000313482095634
Author(s):  
Iswanto Sucandy ◽  
Janelle Spence ◽  
Sharona Ross ◽  
Alexander Rosemurgy

Author(s):  
Chengwei Shao ◽  
Xiaochen Feng ◽  
Jieyu Yu ◽  
Yinghao Meng ◽  
Fang Liu ◽  
...  

2021 ◽  
Author(s):  
Yuki Fukumura ◽  
Yuko Kinowaki ◽  
Yoko Matsuda ◽  
Masaru Takase ◽  
Momoko Tonosaki ◽  
...  

Abstract Pancreatic mucinous cystic neoplasm (MCN) harbors two histological components, tumor epithelia and ovarian-like stroma (OLS). To examine the tumorigenesis of pancreatic MCNs, this study analyzed the distribution, amount, immunohistochemical phenotype, presence of theca cells of the OLS, and the alteration of tumor epithelium of 29 surgically resected MCN cases and compared them with tumor sizes. Non-mucinous type epithelium was present in all low-grade MCNs but its ratio decreased with tumor size (p < 0.05), suggesting that epithelial mucinous changes are a progression phenomenon. The intralobular distribution of OLS was observed in 27.6 % of MCN cases and its existence related to a smaller size (p< 0.05), suggesting intralobular generation of MCNs. Nuclear expression of β-catenin was observed for OLS of everywhere, suggesting consistent activation of the Wnt pathway for OLS. Three MCN cases (10.3%) contained a-smooth muscle actin (SMA)-negative OLS, where OLS surrounding dilated pancreatic ducts or MCN cysts were a-SMA-positive and otherwise negative, suggesting that a-SMA-positivity is an acquired phenomenon of OLS. With this study, we could hypothesize that pancreatic MCNs may generate intralobularly. Epithelial mucinous change and a-SMA-positivity of OLS may be progression phenomena. This is the first study to show the intralobular distribution of OLS.


Author(s):  
Gaku OTA ◽  
Atsushi MIKI ◽  
Kazuhiro ENDO ◽  
Yasunaru SAKUMA ◽  
Alan Kawarai LEFOR ◽  
...  

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