Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population

2015 ◽  
Vol 30 (4) ◽  
pp. 689-695 ◽  
Author(s):  
Gaoxiang Ma ◽  
Dongying Gu ◽  
Chunye Lv ◽  
Haiyan Chu ◽  
Zhi Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Genetic Variant

scholarly journals Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population

Oncotarget ◽  
2015 ◽  
Vol 6 (40) ◽  
pp. 42661-42666 ◽  
Author(s):  
Li-Xin Qiu ◽  
Jing He ◽  
Lei Cheng ◽  
Fei Zhou ◽  
Meng-Yun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Genetic Variant ◽  
Gastric Cancer Risk

scholarly journals Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population

Oncotarget ◽  
2016 ◽  
Vol 7 (13) ◽  
pp. 15930-15936 ◽  
Author(s):  
Li-Xin Qiu ◽  
Rui-Xi Hua ◽  
Lei Cheng ◽  
Jing He ◽  
Meng-Yun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Genetic Variant ◽  
Gastric Cancer Risk

scholarly journals A genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population

Mutagenesis ◽  
2013 ◽  
Vol 28 (4) ◽  
pp. 441-446 ◽  
Author(s):  
H. Chu ◽  
D. Gu ◽  
M. Xu ◽  
Z. Xu ◽  
Y. Gong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Genetic Variant ◽  
Cancer Prognosis

A Genetic Variant in 3′-Untranslated Region of Cyclooxygenases-2 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population

2012 ◽  
Vol 31 (7) ◽  
pp. 1252-1257 ◽  
Author(s):  
Huizhang Li ◽  
Chuanli Ren ◽  
Zhining Fan ◽  
Guangfu Jin ◽  
Jiangbo Du ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Untranslated Region ◽  
Genetic Variant

scholarly journals Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population

2010 ◽  
Vol 129 (5) ◽  
pp. 1207-1213 ◽  
Author(s):  
Meilin Wang ◽  
Jin Bai ◽  
Yongfei Tan ◽  
Shizhi Wang ◽  
Yuanyuan Tian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Genetic Variant ◽  
Diffuse Type ◽  
Diffuse Type Gastric Cancer

scholarly journals Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population

Gut Pathogens ◽  
2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Zhijing Xue ◽  
Yuanhai You ◽  
Lihua He ◽  
Yanan Gong ◽  
Lu Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Amino Acid ◽  
Chinese Population ◽  
Statistical Difference ◽  
Variable Region ◽  
Repeat Region ◽  
Geographical Regions ◽  
H Pylori ◽  
Epiya Motifs

Abstract Background The cytotoxin-associated gene A (cagA) is one of the most important virulence factors of Helicobacter pylori (H. pylori). There is a highly polymorphic Glu-Pro-Ile-Tyr-Ala (EPIYA) repeat region in the C-terminal of CagA protein. This repeat region is thought to play an important role in the pathogenesis of gastrointestinal diseases. The aim of this study was to investigate the diversity of cagA 3′ variable region and the amino acid polymorphisms in the EPIYA segments of the CagA C-terminal region of H. pylori, and their association with gastroduodenal diseases. Methods A total of 515 H. pylori strains from patients in 14 different geographical regions of China were collected. The genomic DNA from each strain was extracted and the cagA 3′ variable region was amplified by polymerase chain reaction (PCR). The PCR products were sequenced and analyzed using MEGA 7.0 software. Results A total of 503 (97.7%) H. pylori strains were cagA-positive and 1,587 EPIYA motifs were identified, including 12 types of EPIYA or EPIYA-like sequences. In addition to the four reported major segments, several rare segments (e.g., B′, B″ and D′) were defined and 20 different sequence types (e.g., ABD, ABC) were found in our study. A total of 481 (95.6%) strains carried the East Asian type CagA, and the ABD subtypes were most prevalent (82.1%). Only 22 strains carried the Western type CagA, which included AC, ABC, ABCC and ABCCCC subtypes. The CagA-ABD subtype had statistical difference in different geographical regions (P = 0.006). There were seven amino acid polymorphisms in the sequences surrounding the EPIYA motifs, among which amino acids 893 and 894 had a statistical difference with gastric cancer (P = 0.004). Conclusions In this study, 503 CagA sequences were studied and analyzed in depth. In Chinese population, most H. pylori strains were of the CagA-ABD subtype and its presence was associated with gastroduodenal diseases. Amino acid polymorphisms at residues 893 and 894 flanking the EPIYA motifs had a statistically significant association with gastric cancer.

Correlations of SNHG5 genetic polymorphisms with susceptibility and prognosis to gastric cancer in a Chinese population

Genomics ◽  
2021 ◽  
Author(s):  
Jian Xiao ◽  
Chuming Zhu ◽  
Peidong Ni ◽  
Wangwang Chen ◽  
Zengliang Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Polymorphisms ◽  
Chinese Population

Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population

2011 ◽  
Vol 35 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Tao Yuan ◽  
Shaoli Deng ◽  
Ming Chen ◽  
Wei Chen ◽  
Weiping Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Repair ◽  
Genetic Susceptibility ◽  
Chinese Population ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0139059 ◽  
Author(s):  
Ping Sun ◽  
Jiangbo Du ◽  
Xun Zhu ◽  
Chuanli Ren ◽  
Lan Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Chinese Population ◽  
Untranslated Region ◽  
Gastric Cancer Risk ◽  
Nbn Gene
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