A Genetic Variant in 3′-Untranslated Region of Cyclooxygenases-2 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population

2012 ◽  
Vol 31 (7) ◽  
pp. 1252-1257 ◽  
Author(s):  
Huizhang Li ◽  
Chuanli Ren ◽  
Zhining Fan ◽  
Guangfu Jin ◽  
Jiangbo Du ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Untranslated Region ◽  
Genetic Variant

scholarly journals Genetic Variation in the 3'-Untranslated Region of NBN Gene Is Associated with Gastric Cancer Risk in a Chinese Population

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0139059 ◽  
Author(s):  
Ping Sun ◽  
Jiangbo Du ◽  
Xun Zhu ◽  
Chuanli Ren ◽  
Lan Xie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Genetic Variation ◽  
Cancer Risk ◽  
Chinese Population ◽  
Untranslated Region ◽  
Gastric Cancer Risk ◽  
Nbn Gene

scholarly journals Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population

Oncotarget ◽  
2015 ◽  
Vol 6 (40) ◽  
pp. 42661-42666 ◽  
Author(s):  
Li-Xin Qiu ◽  
Jing He ◽  
Lei Cheng ◽  
Fei Zhou ◽  
Meng-Yun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Genetic Variant ◽  
Gastric Cancer Risk

scholarly journals Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population

Oncotarget ◽  
2016 ◽  
Vol 7 (13) ◽  
pp. 15930-15936 ◽  
Author(s):  
Li-Xin Qiu ◽  
Rui-Xi Hua ◽  
Lei Cheng ◽  
Jing He ◽  
Meng-Yun Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Genetic Variant ◽  
Gastric Cancer Risk

Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population

2015 ◽  
Vol 30 (4) ◽  
pp. 689-695 ◽  
Author(s):  
Gaoxiang Ma ◽  
Dongying Gu ◽  
Chunye Lv ◽  
Haiyan Chu ◽  
Zhi Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Genetic Variant

scholarly journals Genetic Variants in the 3′ Untranslated Region of sFRP1 Gene and Risk of Gastric Cancer in a Chinese Population

2017 ◽  
Vol 32 (1) ◽  
pp. 102-107
Author(s):  
Juan Wu ◽  
Junfeng Zhang ◽  
Qinhong Cao ◽  
Junqin Wang ◽  
Zhen Zhan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Chinese Population ◽  
Untranslated Region ◽  
Wnt Signaling Pathway ◽  
Negative Regulator ◽  
Polymorphism Analysis ◽  
Human Gastric Cancer ◽  
The Impact

Background Secreted frizzled-related protein 1 (sFRP1), a negative regulator of the Wnt signaling pathway, is frequently inactivated in human gastric cancer. Genetic variants in the 3′ untranslated region (UTR) of the gene may influence the strength of miRNA binding and the regulation of mRNA transcription, affecting the individual's cancer risk. This study aims to investigate the impact of variants in the 3′ UTR of sFRP1 on the gastric cancer susceptibility in a Chinese population. Patients and methods The association between 2 sFRP1 gene variation loci (rs1127379 and rs10088390) with minor allele frequency more than 0.1 in the 3′ UTR and gastric cancer risk was assessed in a case-control study including 419 gastric cancer cases and 571 healthy controls. PCR-restriction fragment length polymorphism analysis was used for genotyping; the odds ratio and 95% confidence interval were calculated to estimate the relative risk. Results Compared with the AA genotype, the GG genotype of rs1127379 was significantly associated with a reduced risk of gastric cancer overall. In the subgroup analysis, the protective effect of the GG genotype was also found for noncardia cancer and intestinal gastric cancer. Furthermore, haplotype analysis showed that the Ars1127379 Grs10088390 haplotype conferred a risk effect for gastric cancer. Conclusions Genetic variants at the sFRP1 gene may be involved in gastric tumorigenesis, especially in noncardia and intestinal gastric cancer. Further prospective studies with different ethnicities and large sample sizes are needed to confirm our findings.

A miR-29c binding site genetic variant in the 3′-untranslated region of LAMTOR3 gene is associated with gastric cancer risk

2015 ◽  
Vol 69 ◽  
pp. 70-75 ◽  
Author(s):  
Peng Song ◽  
Weizhi Wang ◽  
Guoquan Tao ◽  
Haiyan Chu ◽  
Meilin Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Binding Site ◽  
Untranslated Region ◽  
Genetic Variant ◽  
Gastric Cancer Risk

scholarly journals A genetic variant in ERCC2 is associated with gastric cancer prognosis in a Chinese population

Mutagenesis ◽  
2013 ◽  
Vol 28 (4) ◽  
pp. 441-446 ◽  
Author(s):  
H. Chu ◽  
D. Gu ◽  
M. Xu ◽  
Z. Xu ◽  
Y. Gong ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Genetic Variant ◽  
Cancer Prognosis

scholarly journals Genetic variant in PSCA predicts survival of diffuse-type gastric cancer in a Chinese population

2010 ◽  
Vol 129 (5) ◽  
pp. 1207-1213 ◽  
Author(s):  
Meilin Wang ◽  
Jin Bai ◽  
Yongfei Tan ◽  
Shizhi Wang ◽  
Yuanyuan Tian ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Genetic Variant ◽  
Diffuse Type ◽  
Diffuse Type Gastric Cancer
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