scholarly journals “Gastric cytoprotection” is still relevant

2014 ◽  
Vol 29 ◽  
pp. 124-132 ◽  
Author(s):  
Sandor Szabo
Keyword(s):  
Gastric Cytoprotection

Adaptive gastric cytoprotection is mediated by prostaglandin EP1 receptors: A study using rats and knockout mice

2001 ◽  
Vol 120 (5) ◽  
pp. A136
Author(s):  
Koji Takeuchi ◽  
Shinichi Kato ◽  
Hideo Araki ◽  
Yusaku Komoike ◽  
Masamori Takeeda
Keyword(s):  
Knockout Mice ◽  
Gastric Cytoprotection

scholarly journals Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats

2006 ◽  
Vol 21 (3) ◽  
pp. 168-176 ◽  
Author(s):  
Míriam Elias Cavallini ◽  
Nelson Adami Andreollo ◽  
Konradin Metze ◽  
Marina Raquel Araújo
Keyword(s):  
Gastric Mucosa ◽  
Microscopic Analysis ◽  
Control Group ◽  
Average Weight ◽  
Gastric Cytoprotection ◽  
Microscopic Studies ◽  
Group A ◽  
Ad Libitum ◽  
Pre Treatment ◽  
Group B

PURPOSE: To evaluate and to compare macro and microscopically the intense injuries of the gastric mucosa of rats which were caused by NSAIDS celecoxib and indomethacin and the gastric cytoprotection with omeprazole and misoprostol. METHODS: The sample is formed by one hundred and fifty Wistar rats with average weight 200 g, distributed in four groups, such as: Group A, subdivided in groups A1 and A2 - pre-treatment with omeprazole (20 mg/rat) during seven days and on the 8th day - use of NSAIDS, concerning A1 (20 rats) were given celecoxib (1mg/rat) and A2 (20 rats) were given indomethacin. The Group B, subdivided in group B1 and B2 - pre-treatment with misoprostol (20mg/rat) during seven days and on the 8th day use of NSAIDS, concerning B1 (20 rats) were given celecoxib (1 mg/ rat) and B2 (20 rats) were given indomethacin (12.5 mg/rat). The Group C: were not given cytoprotection during seven days, from the 7th to the 8th day - fast of food and water ad libitum, on the 8th day of NSAIDS use, concerning C1 (20 rats) were given celecoxib, C2 (20 rats) were given indomethacin (12.5 mg/ rat), C3 (20 rats) were given celecoxib (200mg/rato), and Group D - control group, concerning 10 rats were observed during seven days ingesting food and water ad libitum. On the 9th day, the stomachs were taken out and were macro and microscopically evaluated for the identification of the gastric injuries. RESULTS: On the macroscopic studies, the groups A2, B2 and C2 presented a remarkable high number of injuries for cm² /animal, respectively 18.55 injuries for cm² /animal, 16.25 injuries for cm² /animal and 13.55 injuries for cm²/animal. On the microscopic studies, the percentage of the injured mucosa, presented expressive difference among the groups A1, B1, C1 when compared to the groups A2, B2, C2 (p<0.0001). The average of the length/injury and the average of the depth of the injuries did not present expressive statistics differences among the groups A2, B2 and C2. The average of the edema presented expressive statistics difference among the groups A2 and D; B2 and C2 and between C2 and D (p < 0.05). CONCLUSIONS: The indomethacin on the applied concentration causes a great number of macroscopic and microscopic injuries to gastric mucosa of rats when compared to celecoxib which does not cause lesions. Omeprazole and misoprostol on the applied concentrations do not present macroscopic and microscopic effectiveness on the gastric cytoprotection when applying indomethacin. Considering the microscopic analysis of the average of the edema, the group of animals, which was given misoprostol as cytoprotection, presented a lower average compared to the group which was given omeprazole.

Gastric Cytoprotection by Prostaglandin E2 — Relation to EP Receptor Subtypes —

2002 ◽  
pp. 169-180
Author(s):  
Koji Takeuchi ◽  
Shinichi Kato ◽  
Yusaku Komoike ◽  
Yoshihiro Ogawa ◽  
Masanori Takeeda
Keyword(s):  
Prostaglandin E2 ◽  
Receptor Subtypes ◽  
Gastric Cytoprotection ◽  
Ep Receptor

Morphologic evaluation of gastric cytoprotection by 16,16-dimethyl PGE2

Micron (1969) ◽  
1981 ◽  
Vol 12 (3) ◽  
pp. 309-310
Author(s):  
K.J. Bonnema ◽  
G.J. Kolaja ◽  
R.C. Piper ◽  
M.J. Ruwart ◽  
C. Lancaster ◽  
...  
Keyword(s):  
Gastric Cytoprotection

Gastric Cytoprotection by Tetraprenylacetone in Human Subjects

Digestion ◽  
1988 ◽  
Vol 39 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Tetsuo Arakawa ◽  
Hiroaki Yamada ◽  
Atsushi Nakamura ◽  
Hiroko Nebiki ◽  
Hiroshi Satoh ◽  
...  
Keyword(s):  
Human Subjects ◽  
Gastric Cytoprotection

Gastric cytoprotection: Morphological perspectives

2008 ◽  
Vol 43 (1-2) ◽  
pp. 2-10
Author(s):  
Akira Terano ◽  
Shinichi Ota ◽  
Hideyuki Hiraishi ◽  
Hiroyuki Mutoh
Keyword(s):  
Gastric Cytoprotection

Gastric Cytoprotection of the Non-Steroidal Anti-Inflammatory Sesquiterpene, β-Caryophyllene

Planta Medica ◽  
1996 ◽  
Vol 62 (05) ◽  
pp. 469-470 ◽  
Author(s):  
Yukihiro Tambe ◽  
Hitomi Tsujiuchi ◽  
Gisho Honda ◽  
Yasumasa Ikeshiro ◽  
Shigeo Tanaka
Keyword(s):  
Gastric Cytoprotection ◽  
Anti Inflammatory

Gastric Cytoprotection

Drugs ◽  
1991 ◽  
Vol 41 (4) ◽  
pp. 507-513 ◽  
Author(s):  
Mario Guslandi
Keyword(s):  
Gastric Cytoprotection
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