Freeze–thaw enhanced stability and mechanical strength of polysaccharide‐based sodium alginate/hyaluronic acid films

2021 ◽  
Author(s):  
Cai‐Yun Li ◽  
Yu‐Bin Zhang ◽  
Yun Han ◽  
Xi‐Ya Zhao ◽  
Fa‐Dong Tian
Keyword(s):  
Hyaluronic Acid ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
Freeze Thaw ◽  
Enhanced Stability

scholarly journals Three-Dimensional Printable Hydrogel Using a Hyaluronic Acid/Sodium Alginate Bio-Ink

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 794 ◽  
Author(s):  
Su Jeong Lee ◽  
Ji Min Seok ◽  
Jun Hee Lee ◽  
Jaejong Lee ◽  
Wan Doo Kim ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Hyaluronic Acid ◽  
Sodium Alginate ◽  
Three Dimensional ◽  
Fibroblast Cell ◽  
Chemical Crosslinking ◽  
Fibroblast Cell Line ◽  
Engineering Applications ◽  
Encapsulated Cells ◽  
Crosslinking Agents

Bio-ink properties have been extensively studied for use in the three-dimensional (3D) bio-printing process for tissue engineering applications. In this study, we developed a method to synthesize bio-ink using hyaluronic acid (HA) and sodium alginate (SA) without employing the chemical crosslinking agents of HA to 30% (w/v). Furthermore, we evaluated the properties of the obtained bio-inks to gauge their suitability in bio-printing, primarily focusing on their viscosity, printability, and shrinkage properties. Furthermore, the bio-ink encapsulating the cells (NIH3T3 fibroblast cell line) was characterized using a live/dead assay and WST-1 to assess the biocompatibility. It was inferred from the results that the blended hydrogel was successfully printed for all groups with viscosities of 883 Pa∙s (HA, 0% w/v), 1211 Pa∙s (HA, 10% w/v), and 1525 Pa∙s, (HA, 30% w/v) at a 0.1 s−1 shear rate. Their structures exhibited no significant shrinkage after CaCl2 crosslinking and maintained their integrity during the culture periods. The relative proliferation rate of the encapsulated cells in the HA/SA blended bio-ink was 70% higher than the SA-only bio-ink after the fourth day. These results suggest that the 3D printable HA/SA hydrogel could be used as the bio-ink for tissue engineering applications.

pH-Sensitive graphene oxide/sodium alginate/polyacrylamide nanocomposite semi-IPN hydrogel with improved mechanical strength

RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 89083-89091 ◽  
Author(s):  
Huijuan Zhang ◽  
Xianjuan Pang ◽  
Yuan Qi
Keyword(s):  
Graphene Oxide ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
Ph Sensitive ◽  
Swelling Behavior ◽  
Ph Dependent

A pH-sensitive and mechanically strong graphene oxide/sodium alginate/polyacrylamide nanocomposite semi-IPN hydrogel was designed and prepared. The composite semi-IPN hydrogel showed superior mechanical strength and pH-dependent swelling behavior.

scholarly journals Synthesis of Water Resistance and Moisture-Permeable Nanofiber Using Sodium Alginate–Functionalized Waterborne Polyurethane

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2882
Author(s):  
Wen-Chi Lu ◽  
Fu-Sheng Chuang ◽  
Manikandan Venkatesan ◽  
Chia-Jung Cho ◽  
Po-Yun Chen ◽  
...  
Keyword(s):  
Mechanical Strength ◽  
Sodium Alginate ◽  
Calcium Chloride ◽  
Strain Curve ◽  
Cost Effective ◽  
Waterborne Polyurethane ◽  
Hydrophilic Nature ◽  
Initial Modulus ◽  
Humid Region ◽  
Crosslinker Concentration

The development of nontoxic and biodegradable alginate-based materials has been a continual goal in biological applications. However, their hydrophilic nature and lack of spinnability impart water instability and poor mechanical strength to the nanofiber. To overcome these limitations, sodium alginate (SA) and waterborne polyurethane (WPU) were blended and crosslinked with calcium chloride; 30 wt % of SA exhibited good compatibility. Further addition of 10 wt % calcium chloride improved the water stability to an extremely humid region. Furthermore, the stress–strain curve revealed that the initial modulus and the elongation strength of the WPU/SA and WPU/CA blends increased with SA content, and the crosslinker concentration clearly indicated the dressing material hardness resulted from this simple blend strategy. The WPU/SA30 electrospun nanofibrous blend contained porous membranes; it exhibited good mechanical strength with water-stable, water-absorbable (37.5 wt %), and moisture-permeable (25.1 g/m2–24 h) characteristics, suggesting our cost-effective material could function as an effective wound dressing material.

Injectable in situ dual-crosslinking hyaluronic acid and sodium alginate based hydrogels for drug release

2019 ◽  
Vol 30 (12) ◽  
pp. 995-1007 ◽  
Author(s):  
Yufan Zhang ◽  
Xian Li ◽  
Nan Zhong ◽  
Yuanlin Huang ◽  
Kewen He ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Drug Release ◽  
Sodium Alginate

scholarly journals Strength, Permeability, and Freeze-Thaw Durability of Pervious Concrete with Different Aggregate Sizes, Porosities, and Water-Binder Ratios

2018 ◽  
Vol 8 (8) ◽  
pp. 1217 ◽  
Author(s):  
Hanbing Liu ◽  
Guobao Luo ◽  
Haibin Wei ◽  
Han Yu
Keyword(s):  
Compressive Strength ◽  
Mechanical Strength ◽  
Aggregate Size ◽  
Pervious Concrete ◽  
High Porosity ◽  
Range Analysis ◽  
Freeze Thaw ◽  
Binder Ratio ◽  
The Impact ◽  
Water Binder Ratio

Pervious concrete (PC), as an environmental friendly material, can be very important in solving urban problems and mitigating the impact of climate change; i.e., flooding, urban heat island phenomena, and groundwater decline. The objective of this research is to evaluate the strength, permeability, and freeze-thaw durability of PC with different aggregate sizes, porosities, and water-binder ratios. The orthogonal experiment method is employed in the study and nine experiments are conducted. The compressive strength, flexural strength, permeability coefficient, porosity, density, and freeze-thaw durability of PC mixtures are tested. Range analysis and variance analysis are carried out to analyze the collected data and estimate the influence of aggregate size, porosity, and water-binder ratio on PC properties. The results indicate that porosity is the most important factor determining the properties of PC. High porosity results in better permeability, but negatively affects the mechanical strength and freeze-thaw durability. PC of 15% porosity can obtain high compressive strength in excess of 20 MPa and favorable freeze-thaw durability of 80 cycles without sacrificing excessive permeability. Aggregate size also has a significant effect on freeze-thaw durability and mechanical strength. Small aggregate size is advantageous for PC properties. PC with 4.75–9.5 mm coarse aggregate presents excellent freeze-thaw durability. The influence of the water-binder ratio on PC properties is not as significant as that of aggregate size and porosity. An optimal mix ratio is required to trade-off between permeability, mechanical strength, and freeze-thaw durability.

Potential application of an injectable hydrogel scaffold loaded with mesenchymal stem cells for treating traumatic brain injury

2018 ◽  
Vol 6 (19) ◽  
pp. 2982-2992 ◽  
Author(s):  
Kun Zhang ◽  
Zhenqing Shi ◽  
Jiankang Zhou ◽  
Qu Xing ◽  
Shanshan Ma ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Brain Injury ◽  
Sodium Alginate ◽  
Potential Application ◽  
Hydrogel Scaffold ◽  
Injectable Hydrogel ◽  
Tissue Scaffold

In this contribution, we developed an injectable hydrogel composed of sodium alginate and hyaluronic acid that acts as a tissue scaffold to create a more optimal microenvironment for the stem cells for potential application of traumatic brain injury implantation.

scholarly journals Effect of sodium alginate on the stability of natural soybean oil body emulsions

RSC Advances ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 4731-4741 ◽  
Author(s):  
Chunxia Su ◽  
Younan Feng ◽  
Jing Ye ◽  
Yuemei Zhang ◽  
Zhiming Gao ◽  
...  
Keyword(s):  
Soybean Oil ◽  
Sodium Alginate ◽  
Oil Body ◽  
Freeze Thaw ◽  
The Stability ◽  
First Time

For the first time sodium alginate is used to improve the stability of oil body emulsions against salt, pH and freeze–thaw cycling.

Sign in / Sign up

Export Citation Format

Share Document