Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A‐loaded liposomes

2021 ◽  
Author(s):  
Jing Liu ◽  
Zhongan Zhu ◽  
Yuhang Yang ◽  
Michael Adu‐Frimpong ◽  
Lin Chen ◽  
...  
Keyword(s):  
Licochalcone A

scholarly journals Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial

2020 ◽  
Vol Volume 12 ◽  
pp. 961-967
Author(s):  
Federica Dall'Oglio ◽  
Gabriella Fabbrocini ◽  
Aurora Tedeschi ◽  
Marianna Donnarumma ◽  
Paolo Chiodini ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Prospective Trial ◽  
Licochalcone A

Licochalcone A Attenuates Chronic Neuropathic Pain in Rats by Inhibiting Microglia Activation and Inflammation

2021 ◽  
Vol 46 (5) ◽  
pp. 1112-1118
Author(s):  
Ping Li ◽  
Chao Yu ◽  
Fan-Shuo Zeng ◽  
Xiaoyan Fu ◽  
Xiao-Jing Yuan ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Microglia Activation ◽  
Chronic Neuropathic Pain ◽  
Licochalcone A

Licochalcone A inhibits enterovirus A71 replication in vitro and in vivo

2021 ◽  
pp. 105091
Author(s):  
Yiming Cao ◽  
En Lei ◽  
Xiaolong Wang ◽  
Xiangyun Qi ◽  
Lei Li ◽  
...  
Keyword(s):  
Licochalcone A ◽  
Enterovirus A71

Hypoglycemic Effects of Licochalcone A on the Streptozotocin-Induced Diabetic Mice and Its Mechanism Study

2021 ◽  
Author(s):  
Zhonghua Luo ◽  
Chaofan Fu ◽  
Tao Li ◽  
Qingqing Gao ◽  
Dongyu Miao ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Mechanism Study ◽  
Licochalcone A

Licochalcone A inhibits the formation and bone resorptive activity of osteoclasts

2008 ◽  
Vol 32 (9) ◽  
pp. 1064-1072 ◽  
Author(s):  
Soon Nam Kim ◽  
Myung Hee Kim ◽  
Yong Ki Min ◽  
Seong Hwan Kim
Keyword(s):  
Licochalcone A ◽  
Resorptive Activity

Antispasmodic activity of licochalcone A, a species-specific ingredient ofGlycyrrhiza inflataroots

2007 ◽  
Vol 59 (10) ◽  
pp. 1421-1426 ◽  
Author(s):  
Hidemasa Nagai ◽  
Ju-Xiu He ◽  
Tadato Tani ◽  
Teruaki Akao
Keyword(s):  
Antispasmodic Activity ◽  
Licochalcone A ◽  
Species Specific

scholarly journals Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Xuan Yuan ◽  
Defang Li ◽  
Hong Zhao ◽  
Jiangtao Jiang ◽  
Penglong Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Parp Cleavage ◽  
Ros Generation ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Licochalcone A ◽  
T24 Cells ◽  
Stress Dependent

Licochalcone A (LCA), a licorice chalconoid, is considered to be a bioactive agent with chemopreventive potential. This study investigated the mechanisms involved in LCA-induced apoptosis in human bladder cancer T24 cells. LCA significantly inhibited cells proliferation, increased reactive oxygen species (ROS) levels, and caused T24 cells apoptosis. Moreover, LCA induced mitochondrial dysfunction, caspase-3 activation, and poly-ADP-ribose polymerase (PARP) cleavage, which displayed features of mitochondria-dependent apoptotic signals. Besides, exposure of T24 cells to LCA triggered endoplasmic reticulum (ER) stress; as indicated by the enhancement in 78 kDa glucose-regulated protein (GRP 78), growth arrest and DNA damage-inducible gene 153/C/EBP homology protein (GADD153/CHOP) expression, ER stress-dependent apoptosis is caused by the activation of ER-specific caspase-12. All the findings from our study suggest that LCA initiates mitochondrial ROS generation and induces oxidative stress that consequently causes T24 cell apoptosis via the mitochondria-dependent and the ER stress-triggered signaling pathways.

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