Nutritional and phytochemical profile of pomegranate (“Wonderful variety”) peel and its effects on hepatic oxidative stress and metabolic alterations

2021 ◽  
Author(s):  
Eunice A. Akuru ◽  
Chika I. Chukwuma ◽  
Chika E. Oyeagu ◽  
Ochuko L. Erukainure ◽  
Boitumelo Mashile ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Alterations ◽  
Hepatic Oxidative Stress ◽  
Wonderful Variety ◽  
Phytochemical Profile

scholarly journals Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats

Biology Open ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. bio047282
Author(s):  
Ellen Mayara Souza Cruz ◽  
Juliana Maria Bitencourt de Morais ◽  
Carlos Vinícius Dalto da Rosa ◽  
Mellina da Silva Simões ◽  
Jurandir Fernando Comar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Sucrose Solution ◽  
Metabolic Alterations ◽  
Hepatic Oxidative Stress

Black Tea-Induced Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in EAC-Bearing Mice

2007 ◽  
Vol 26 (4) ◽  
pp. 245-254 ◽  
Author(s):  
Arindam Bhattacharyya ◽  
Debaprasad Mandal ◽  
Lakshmishri Lahiry ◽  
Sankar Bhattacharyya ◽  
Sreya Chattopadhyay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidative Activity ◽  
Black Tea ◽  
Hepatic Oxidative Stress ◽  
Induced Amelioration

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD

2021 ◽  
Author(s):  
Jingda Li ◽  
Tianqi Wang ◽  
Panpan Liu ◽  
Fuyuan Yang ◽  
Xudong Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oleic Acid ◽  
Rat Model ◽  
High Fat Diet ◽  
Hepg2 Cells ◽  
Citrus Fruits ◽  
High Fat ◽  
Hepatic Oxidative Stress

Hesperetin as a major bioflavonoid in citrus fruits improves NAFLD by suppressing hepatic oxidative stress and inflammation.

Silymarin alleviates hepatic oxidative stress and protects against metabolic disorders in high-fat diet-fed mice

2016 ◽  
Vol 50 (3) ◽  
pp. 314-327 ◽  
Author(s):  
Bin Feng ◽  
Ran Meng ◽  
Bin Huang ◽  
Shanmei Shen ◽  
Yan Bi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Hepatic Oxidative Stress

scholarly journals A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats

2017 ◽  
Vol 117 (2) ◽  
pp. 218-229 ◽  
Author(s):  
K. Gil-Cardoso ◽  
I. Ginés ◽  
M. Pinent ◽  
A. Ardévol ◽  
X. Terra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intestinal Inflammation ◽  
Cafeteria Diet ◽  
Zucker Rats ◽  
Standard Diet ◽  
Metabolic Alterations ◽  
Genetic Obesity ◽  
Obesogenic Diet ◽  
The Impact ◽  
And Oxidative Stress

AbstractThe gastrointestinal alterations associated with the consumption of an obesogenic diet, such as inflammation, permeability impairment and oxidative stress, have been poorly explored in both diet-induced obesity (DIO) and genetic obesity. The aim of the present study was to examine the impact of an obesogenic diet on the gut health status of DIO rats in comparison with the Zucker (fa/fa) rat leptin receptor-deficient model of genetic obesity over time. For this purpose, female Wistar rats (n 48) were administered a standard or a cafeteria diet (CAF diet) for 12, 14·5 or 17 weeks and were compared with fa/fa Zucker rats fed a standard diet for 10 weeks. Morphometric variables, plasma biochemical parameters, myeloperoxidase (MPO) activity and reactive oxygen species (ROS) levels in the ileum were assessed, as well as the expressions of proinflammatory genes (TNF-α and inducible nitric oxide synthase (iNOS)) and intestinal permeability genes (zonula occludens-1, claudin-1 and occludin). Both the nutritional model and the genetic obesity model showed increased body weight and metabolic alterations at the final time point. An increase in intestinal ROS production and MPO activity was observed in the gastrointestinal tracts of rats fed a CAF diet but not in the genetic obesity model. TNF-α was overexpressed in the ileum of both CAF diet and fa/fa groups, and ileal inflammation was associated with the degree of obesity and metabolic alterations. Interestingly, the 17-week CAF group and the fa/fa rats exhibited alterations in the expressions of permeability genes. Relevantly, in the hyperlipidic refined sugar diet model of obesity, the responses to chronic energy overload led to time-dependent increases in gut inflammation and oxidative stress.

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