The interaction effect between tea polyphenols and intestinal microbiota: Role in ameliorating neurological diseases

2021 ◽  
Author(s):  
Mengyu Hong ◽  
Ruilin Zhang ◽  
Yanan Liu ◽  
Zufang Wu ◽  
Peifang Weng
Keyword(s):  
Intestinal Microbiota ◽  
Interaction Effect ◽  
Neurological Diseases ◽  
Tea Polyphenols

The interaction effect and mechanism between tea polyphenols and intestinal microbiota: Role in human health

2017 ◽  
Vol 41 (6) ◽  
pp. e12415 ◽  
Author(s):  
Mei Cheng ◽  
Xin Zhang ◽  
Xiao-Jing Guo ◽  
Zu-Fang Wu ◽  
Pei-Fang Weng
Keyword(s):  
Human Health ◽  
Intestinal Microbiota ◽  
Interaction Effect ◽  
Tea Polyphenols

scholarly journals Tea Polyphenols in Promotion of Human Health

Nutrients ◽  
2018 ◽  
Vol 11 (1) ◽  
pp. 39 ◽  
Author(s):  
Naghma Khan ◽  
Hasan Mukhtar
Keyword(s):  
Green Tea ◽  
Animal Studies ◽  
Neurological Diseases ◽  
Black Tea ◽  
Polyphenolic Compounds ◽  
Tea Polyphenols ◽  
Beneficial Effects ◽  
Gallocatechin Gallate ◽  
Prevention Of Cancer ◽  
Pharmacologically Active

Tea is the most widely used beverage worldwide. Japanese and Chinese people have been drinking tea for centuries and in Asia, it is the most consumed beverage besides water. It is a rich source of pharmacologically active molecules which have been implicated to provide diverse health benefits. The three major forms of tea are green, black and oolong tea based on the degree of fermentation. The composition of tea differs with the species, season, leaves, climate, and horticultural practices. Polyphenols are the major active compounds present in teas. The catechins are the major polyphenolic compounds in green tea, which include epigallocatechin-3-gallate (EGCG), epigallocatechin, epicatechin-3-gallate and epicatechin, gallocatechins and gallocatechin gallate. EGCG is the predominant and most studied catechin in green tea. There are numerous evidences from cell culture and animal studies that tea polyphenols have beneficial effects against several pathological diseases including cancer, diabetes and cardiovascular diseases. The polyphenolic compounds present in black tea include theaflavins and thearubigins. In this review article, we will summarize recent studies documenting the role of tea polyphenols in the prevention of cancer, diabetes, cardiovascular and neurological diseases.

scholarly journals The Contribution of Gut Microbiota–Brain Axis in the Development of Brain Disorders

2021 ◽  
Vol 15 ◽  
Author(s):  
Jessica Maiuolo ◽  
Micaela Gliozzi ◽  
Vincenzo Musolino ◽  
Cristina Carresi ◽  
Federica Scarano ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Current Knowledge ◽  
Neurological Diseases ◽  
Bacterial Species ◽  
Autism Spectrum ◽  
Human Organism ◽  
Close Relationship ◽  
Neuronal Alteration ◽  
The Brain

Different bacterial families colonize most mucosal tissues in the human organism such as the skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian intestine hosts a microbial community of between 1,000 and 1,500 bacterial species, collectively called “microbiota.” Co-metabolism between the microbiota and the host system is generated and the symbiotic relationship is mutually beneficial. The balance that is achieved between the microbiota and the host organism is fundamental to the organization of the immune system. Scientific studies have highlighted a direct correlation between the intestinal microbiota and the brain, establishing the existence of the gut microbiota–brain axis. Based on this theory, the microbiota acts on the development, physiology, and cognitive functions of the brain, although the mechanisms involved have not yet been fully interpreted. Similarly, a close relationship between alteration of the intestinal microbiota and the onset of several neurological pathologies has been highlighted. This review aims to point out current knowledge as can be found in literature regarding the connection between intestinal dysbiosis and the onset of particular neurological pathologies such as anxiety and depression, autism spectrum disorder, and multiple sclerosis. These disorders have always been considered to be a consequence of neuronal alteration, but in this review, we hypothesize that these alterations may be non-neuronal in origin, and consider the idea that the composition of the microbiota could be directly involved. In this direction, the following two key points will be highlighted: (1) the direct cross-talk that comes about between neurons and gut microbiota, and (2) the degree of impact of the microbiota on the brain. Could we consider the microbiota a valuable target for reducing or modulating the incidence of certain neurological diseases?

scholarly journals Gut Microbiota Mediates Oolong Tea Polyphenols Alleviation of Circadian Rhythm Disturbance

2021 ◽  
Author(s):  
Ruonan Yan ◽  
Chi-Tang Ho ◽  
Yanan Liu ◽  
Ruilin Zhang ◽  
Zufang Wu ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Clock Genes ◽  
Tea Polyphenols ◽  
Continuous Darkness ◽  
Circadian Rhythm Disorder ◽  
Host Health ◽  
Rhythm Disorder ◽  
Circadian Rhythm Disorders

Abstract BackgroundTea polyphenols can be digested in the intestinal tract so as to promote the growth of helpful gut microbiota, and through the production of catechin, tryptophan, acetic acid and other active substances which involved in the modulation of circadian rhythms mechanism to improve the circadian rhythm disorders and neurological weakness, while its specific mechanism is still unclear. The interaction between host circadian rhythm and gut microbes through the gut-brain axis (GBA) provides new clues for tea polyphenols to improve host health. Our present research mainly investigated the metabolites of the gut microbiota and the heterogeneous expression of circadian rhythm genes in the liver and hypothalamic, and then revealed the modulatory role of oolong tea polyphenols (OTP) of circadian rhythm disorder via the GBA. We used 16S rDNA and untargeted metabolomics sequencing techniques to analyze the effects of OTP on intestinal flora diversity and abundance of specific flora in mice with diurnal disorders, and to screen out marker metabolites which may be involved in circadian rhythm regulation. Transcriptomics and 10X single-cell sequencing were used to evaluate the effects of OTP on circadian rhythm genes in liver and hypothalamus and hypothalamus cell types in mice with diurnal disorders. The Y maze and Morris water maze experiments were investigated the effects of OTP on long-term and short-term memory impairment.ResultsBy establishing a circadian rhythm disorder mouse model, our experimental results showed that OTP improved the structural disorder of the intestinal microbiota caused by continuous darkness, especially significantly decreased the ratio of Firmicutes/Bacteroidetes (F/B), thereby modulating the production of metabolites related to pyruvate metabolism, glycolysis/gluconeogenesis, and tryptophan metabolism to alleviate the steady-state imbalance caused by circadian rhythm disorders. In addition, OTP can significantly ameliorate the rhythm oscillation disorder of specific gut microbes and liver clock genes induced by continuous darkness, and made dysrhythmic mice perform well in cognitive behavior tests. Simultaneously, OTP intervention increased the number of rhythmic expression genes in the liver which in the CD group has 156, while in the OTP group has 208. Transplanting fecal microbiota from the OTP group into germ-free mice exhibited that OTP significantly increased the number of hypothalamus cell clusters, up-regulated the number of astrocytes and fibroblasts, and enhanced the expression of circadian rhythm genes Cry2, Per3, Bhlhe41, Nr1d1, Nr1d2, Dbp, and Rorb in hypothalamic cells. ConclusionsOur results confirmed that OTP reduced the F/B ratio, made the daily oscillation of the intestinal microbiota tended to be regular, actively improve the intestinal microecological status, the content of important metabolite closely associated with circadian rhythm such as Tryptophan, Glutamine, 2-indolecarboxylic acid and some others has been significantly increased, the poor expression of clock genes (such as Cry2, Per3, Bhlhe41, Nr1d1, Nr1d2, Dbp and Rorb) in liver and hypothalamus cells has been improved. These results indicated that OTP can significantly improve the metabolic imbalance and cognitive impairment caused by the circadian rhythm disorder, maintain the host's homeostasis, which with potential prebiotic functional characteristics to positively contribute to host health.

Dietary tea polyphenols induce changes in immune response and intestinal microbiota in Koi carp, cryprinus carpio

Aquaculture ◽  
2020 ◽  
Vol 516 ◽  
pp. 734636 ◽  
Author(s):  
R. Zhang ◽  
L.-L. Liu ◽  
X.-W. Wang ◽  
C.-Y. Guo ◽  
H. Zhu
Keyword(s):  
Immune Response ◽  
Intestinal Microbiota ◽  
Tea Polyphenols ◽  
Koi Carp
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