Green tea polyphenols reduce obesity in high-fat diet-induced mice by modulating intestinal microbiota composition

2017 ◽  
Vol 52 (8) ◽  
pp. 1723-1730 ◽  
Author(s):  
Xiaojing Guo ◽  
Mei Cheng ◽  
Xin Zhang ◽  
Jinxuan Cao ◽  
Zufang Wu ◽  
...  
Keyword(s):  
Green Tea ◽  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Microbiota Composition ◽  
High Fat

Effects of green tea polyphenols on trace metals level of rats on food restriction and high-fat diet

2019 ◽  
Vol 51 ◽  
pp. 91-97
Author(s):  
Nannan Wu ◽  
Guangyu Yang ◽  
Chong Tian ◽  
Weijie Yi ◽  
Shuiqing He ◽  
...  
Keyword(s):  
Trace Metals ◽  
Green Tea ◽  
High Fat Diet ◽  
Food Restriction ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
High Fat

Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High-Fat Diet Treated HFA Mice

2018 ◽  
Vol 83 (3) ◽  
pp. 864-873 ◽  
Author(s):  
Li Wang ◽  
Benhua Zeng ◽  
Zhiwei Liu ◽  
Zhenlin Liao ◽  
Qingping Zhong ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Green Tea ◽  
High Fat Diet ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
High Fat ◽  
Colonic Microbiota ◽  
Microbiota Diversity

scholarly journals Effect of Geranylgeraniol and Green Tea Polyphenols on High-fat-diet-induced Bone Deterioration in Male B6 Mice (P06-025-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Chwan-Li Shen ◽  
Gurvinder Kaur ◽  
Jannette Dufour ◽  
Latha Ramalingam ◽  
Eunhee Chung ◽  
...  
Keyword(s):  
Green Tea ◽  
Bone Health ◽  
High Fat Diet ◽  
Lumbar Vertebrae ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Type I ◽  
Serum Concentrations ◽  
High Fat ◽  
Final Body Weight

Abstract Objectives To investigate the combined effects of geranylgeraniol (GG, a 20-carbon isoprenoid found in fruits, vegetables, and grains) and green tea polyphenols (GTP, extracted from green tea) on high-fat-diet (HFD) induced bone deterioration in obese male mice. Our previous studies demonstrated that GG or GTP, when supplemented separately, was beneficial to the bone health of obese animals. Therefore, we hypothesized that GG combined with GTP would improve bone structure of obese mice fed a HFD. Methods Forty-eight male C57BL/6 J mice were assigned to 4 groups (n = 12/group) in a 2 (no GG vs. GG) × 2 (no GTP vs. GTP) factorial design: HFD, HFD + GG (400 mg GG/kg diet), HFD + GTP [0.5% (w/v) in drinking water], and HFD + GG + GTP. Animals were fed the respective diet ad libitum for 14 weeks. Results GTP supplementation, not GG, resulted in lower final body weight and greater fasting serum insulin concentrations. Supplementation of GG or GTP (separate, but not together) lowered blood glucose concentrations at 120 min. A decreased area under the curve of glucose tolerance tests and insulin tolerance test in the HFD + GG + GTP group was observed suggesting improved glucose clearance and insulin sensitivity, but no interaction was found between GG and GTP. Neither GG nor GTP affected serum concentrations of insulin or procollagen type I intact N-terminal (a bone formation marker). There was an interaction effect for serum concentrations of collagen type 1 cross-linked C-telopeptide (CTX, a bone resorption marker), resulting in HFD + GG + GTP being the lowest. Neither GG nor GTP supplementation affected the total area, bone area, and cortical thickness at the femur midshaft or the bone volume/total volume at the lumbar vertebrae. GG supplementation increased trabecular number and decreased trabecular separation at the lumbar vertebrae. GTP supplementation increased trabecular thickness at lumbar vertebrae. HFD + GG produced the greatest connectivity density and the lowest structure model index. Conclusions This study suggests a beneficial role of supplementing GG with GTP in bone health of obese animals. Funding Sources The study was supported by American River Nutrition to CLS and USDA ARS Project no. 3062-51,000-053-00D.

scholarly journals Green Tea Polyphenols Ameliorate the Early Renal Damage Induced by a High-Fat Diet via Ketogenesis/SIRT3 Pathway

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Weijie Yi ◽  
Xiao Xie ◽  
Miying Du ◽  
Yongjun Bu ◽  
Nannan Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Green Tea ◽  
High Fat Diet ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Activity Levels ◽  
High Fat ◽  
Sirt3 Expression ◽  
Renal Expression ◽  
Expression And Activity

Scope. Several reports in the literature have suggested the renoprotective effects of ketone bodies and green tea polyphenols (GTPs). Our previous study found that GTP consumption could elevate the renal expression of the ketogenic rate-limiting enzyme, which was decreased by a high-fat diet (HFD) in rats. Here, we investigated whether ketogenesis can mediate renoprotection by GTPs against an HFD. Methods and Results. Wistar rats were fed a standard or HFD with or without GTPs for 18 weeks. The renal oxidative stress level, kidney function, renal expression, and activity levels of mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase 2 (HMGCS2) and sirtuin 3(SIRT3) were detected. The increased renal oxidative stress and the loss of renal function induced by the HFD were ameliorated by GTPs. Renal ketogenesis and SIRT3 expression and activity levels, which were reduced by the HFD, were restored by GTPs. In vitro, HEK293 cells were transfected with the eukaryotic expression plasmid pcDNA HMGCS2. GTP treatment could upregulate HMGCS2 and SIRT3 expression. Although SIRT3 expression was not affected by HMGCS2 transfection, the 4-hydroxy-2-nonenal (4-HNE) level and the acetyl-MnSOD (K122)/MnSOD ratio were reduced in HMGCS2-transfected cells in the context of H2O2. Conclusion. The ketogenesis/SIRT3 pathway mediates the renoprotection of GTPs against the oxidative stress induced by an HFD.

scholarly journals Green Tea Polyphenols, Mimicking the Effects of Dietary Restriction, Ameliorate High-Fat Diet-Induced Kidney Injury via Regulating Autophagy Flux

Nutrients ◽  
2017 ◽  
Vol 9 (5) ◽  
pp. 497 ◽  
Author(s):  
Xiao Xie ◽  
Weijie Yi ◽  
Piwei Zhang ◽  
Nannan Wu ◽  
Qiaoqiao Yan ◽  
...  
Keyword(s):  
Green Tea ◽  
Dietary Restriction ◽  
High Fat Diet ◽  
Kidney Injury ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
High Fat ◽  
Autophagy Flux

Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet–induced obese rats

2012 ◽  
Vol 32 (6) ◽  
pp. 448-457 ◽  
Author(s):  
Chwan-Li Shen ◽  
Jay J. Cao ◽  
Raul Y. Dagda ◽  
Samuel Chanjaplammootil ◽  
Chuanwen Lu ◽  
...  
Keyword(s):  
Body Composition ◽  
Green Tea ◽  
Bone Quality ◽  
High Fat Diet ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
High Fat ◽  
Obese Rats
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