Anti‐androgenic effect of astaxanthin in LNCaP cells is mediated through the aryl hydrocarbon‐androgen receptors cross talk

2021 ◽  
Vol 45 (4) ◽  
Author(s):  
Nima Montazeri‐Najafabady ◽  
Nazanin Chatrabnous ◽  
Mohammad‐Reza Arabnezhad ◽  
Negar Azarpira
Keyword(s):  
Cross Talk ◽  
Androgen Receptors ◽  
Lncap Cells ◽  
Aryl Hydrocarbon ◽  
Androgenic Effect

Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk

Steroids ◽  
2020 ◽  
Vol 153 ◽  
pp. 108508 ◽  
Author(s):  
Mohammad-Reza Arabnezhad ◽  
Nima Montazeri-Najafabady ◽  
Nazanin Chatrabnous ◽  
Ali Ghafarian Bahreman ◽  
Afshin Mohammadi-Bardbori
Keyword(s):  
Cross Talk ◽  
Androgen Receptors ◽  
Lncap Cells ◽  
Aryl Hydrocarbon ◽  
Androgenic Effect

ZUM WIRKUNGSMECHANISMUS VON AN FETEN ANTIMASKULIN WIRKSAMEN GESTAGENEN

1964 ◽  
Vol 45 (4_Suppl) ◽  
pp. S139-S153 ◽  
Author(s):  
K. Junkmann ◽  
F. Neumann
Keyword(s):  
Pituitary Gland ◽  
Mechanism Of Action ◽  
Androgen Receptors ◽  
Male Rat ◽  
Pregnant Rats ◽  
Target Organs ◽  
Causative Factors ◽  
Competitive Action ◽  
Androgenic Effect

ABSTRACT Experiments are described dealing with the mechanism of action of 6-chloro-Δ6-1,2α-methylene-17α-hydroxyprogesterone-acetate with regard to its anti-masculine effect on male rat foetuses, when administered to pregnant rats. It was shown that a marked direct anti-androgenic effect due to a competitive action on androgen receptors within the target organs, is probably the explanation of the mechanism of action. It was further shown that an oestrogenic effect or an appreciable inhibition of the pituitary gland respectively, can be ruled out as causative factors in the mechanism of action.

scholarly journals Cross-Talk in the Female Rat Mammary Gland: Influence of Aryl Hydrocarbon Receptor on Estrogen Receptor Signaling

2016 ◽  
Vol 124 (5) ◽  
pp. 601-610 ◽  
Author(s):  
Janina Helle ◽  
Manuela I. Bader ◽  
Annekathrin M. Keiler ◽  
Oliver Zierau ◽  
Günter Vollmer ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Mammary Gland ◽  
Aryl Hydrocarbon Receptor ◽  
Cross Talk ◽  
Female Rat ◽  
Receptor Signaling ◽  
Aryl Hydrocarbon ◽  
Estrogen Receptor Signaling ◽  
Rat Mammary Gland

The effect of benzo[α]pyrene on expression and signaling cross talk of aryl hydrocarbon receptor and NFATc1 in mouse lung tissue

2014 ◽  
Vol 32 (7) ◽  
pp. 1246-1253 ◽  
Author(s):  
Maliheh Parsa ◽  
Seyed Nasser Ostad ◽  
Seyed Mohammad Hossein Noori Moogahi ◽  
Mohammad Bayat ◽  
Mohammad Hossein Ghahremani
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Lung Tissue ◽  
Cross Talk ◽  
Environmental Pollutants ◽  
Lung Damage ◽  
Mouse Lung ◽  
Aryl Hydrocarbon ◽  
Embedded Blocks ◽  
Mouse Lung Tissue ◽  
Imagej Software

Objective: Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T cell (NFAT) pathway is unclear. AhR and NFAT signaling pathways have common roles in pathological functions in immunotoxicity and lung cancer. In this study, the effect of AhR activation on expression and signaling cross talk of AhR and NFATc1 pathways in mouse lung tissue has been investigated. Methods: Swiss albino mice were randomly allocated to five groups and administered with cyclosporin A (CsA) and B[α]P for seven constitutive days. Animals were then killed, and lung tissues were obtained after washing the whole blood. Paraffin-embedded blocks were prepared, and 5 µm sections were cut for histopathological and immunohistochemical assessments. The results were scored by observer and digitally analyzed using ImageJ software. Results: Our data showed that CsA administration resulted in a significant reduction of AhR expression. This effect was partly blocked in mice coadministrated with B[α]P and CsA. NFATc1 expression was also reduced in CsA-treated animals. Furthermore, CsA inhibited the pathological effects of B[α]P in mouse lung tissue. Conclusion: AhR expression is dependent on NFATc1 activation, and NFATc1 inhibition remarkably decreases AhR expression. However, it seems that total expression of NFATc1 is not dependent on AhR expression or activation. Moreover, CsA can prevent B[α]P-induced lung tissue damage, and it remarkably decreases NFATc1 expression. The results from this study point toward the molecular interactions of AhR and NFATc1 activation in lung tissue and the benefit of CsA treatment in B[α]P-induced lung damage.

scholarly journals Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk

2019 ◽  
Vol 10 ◽  
Author(s):  
Monica Borghi ◽  
Marilena Pariano ◽  
Valentina Solito ◽  
Matteo Puccetti ◽  
Marina M. Bellet ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Cross Talk ◽  
Vulvovaginal Candidiasis ◽  
Aryl Hydrocarbon

Dehydroepiandrosterone Activates Mutant Androgen Receptors Expressed in the Androgen-Dependent Human Prostate Cancer Xenograft CWR22 and LNCaP Cells

1997 ◽  
Vol 11 (4) ◽  
pp. 450-459 ◽  
Author(s):  
Jiann-an Tan ◽  
Yousuf Sharief ◽  
Katherine G. Hamil ◽  
Christopher W. Gregory ◽  
De-Ying Zang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptors ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Lncap Cells

Aryl hydrocarbon receptor signaling involved in the invasiveness of LNCaP cells

Human Cell ◽  
2017 ◽  
Vol 30 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Hisamitsu Ide ◽  
Yan Lu ◽  
Jingsong Yu ◽  
Takahiro Noguchi ◽  
Mayuko Kanayama ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Signaling ◽  
Lncap Cells ◽  
Aryl Hydrocarbon

scholarly journals Chimeric molecules facilitate the degradation of androgen receptors and repress the growth of LNCaP cells

2008 ◽  
Vol 11 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Yue-Qing Tang ◽  
Bang-Min Han ◽  
Xin-Quan Yao ◽  
Yan Hong ◽  
Yan Wang ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Lncap Cells ◽  
Chimeric Molecules
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