Anticancer effect of purified polysaccharide from marine clam Donax variabilis on A549 cells

2020 ◽  
Vol 44 (11) ◽  
Author(s):  
Gracy Jenifer Sahayanathan ◽  
Deepakrajasekar Padmanaban ◽  
Kavitha Raja ◽  
Arulvasu Chinnasamy
Keyword(s):  
A549 Cells ◽  
Anticancer Effect ◽  
Donax Variabilis

Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts

2018 ◽  
Vol 37 (2) ◽  
pp. 201-209 ◽  
Author(s):  
V. S. Pokrovsky ◽  
N. Yu Anisimova ◽  
D. Zh Davydov ◽  
S. V. Bazhenov ◽  
N. V. Bulushova ◽  
...  
Keyword(s):  
Human Cancer ◽  
A549 Cells ◽  
Anticancer Effect ◽  
Clostridium Sporogenes ◽  
Methionine Gamma Lyase

scholarly journals Hydroxychloroquine enhances anticancer effect of DOX/folate-phytosterol-carboxymethyl cellulose nanoparticles in A549 lung cancer cells

2020 ◽  
Vol 19 (2) ◽  
pp. 219-225
Author(s):  
Ezzat H. Elshazly ◽  
Song Zhang ◽  
Lizhen Yu ◽  
Yue Zhang ◽  
Lixia Ke ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Wound Healing ◽  
Cellular Uptake ◽  
Carboxymethyl Cellulose ◽  
Human Lung ◽  
A549 Cells ◽  
Wound Healing Assay ◽  
Anticancer Effect ◽  
And Migration ◽  
Proliferation And Migration

Purpose: To study the in vitro anticancer effect of doxorubicin-loaded folate-phytosterol-carboxymethyl cellulose nanoparticles (DOX/FPCMC NPs), alone and in combination with the antimalarial drug hydroxychloroquine (HCQ) on human lung cancer cells (A549 cells). Methods: Human lung adenocarcinoma A549 cell line was treated with blank FPCMC NPs, HCQ, free DOX, DOX/FPCMC NPs, free DOX + HCQ or DOX/FPCMC NPs + HCQ. The concentrations of HCQ, DOX and FPCMC NPs varied within the ranges of 20-120 μmol/L, 2-12 mg/L and 50-500 mg/L, respectively. Cell viability and free folate competitive inhibition were determined using MTT assay. Cell proliferation and migration were investigated with wound healing assay, while confocal laser scanning microscopy (CLSM) was used to determine cellular uptake of drugs. Results: In all formulations, the DOX/FPCMC NPs + HCQ produced the highest cytotoxicity in A549 cells due to high cytotoxicity arising from folate-receptor-mediated endocytosis and HCQ-induced inhibition of autophagy. Free folate competitively inhibited the cytotoxicity of DOX/FPCMC NPs on A549 cells. Wound healing assay showed that A549 cells treated with DOX/FPCMC NPs + HCQ had the lowest cell levels of proliferation and migration capacity. The cellular uptake of DOX/FPCMC NPs by A549 cells was higher than that of free DOX. Conclusion: The combination of DOX/FPCMC NPs and HCQ produced the best antitumor effect and had a promising potential for reversal of MDR Keywords: Folate-phytosterol-carboxymethyl cellulose, Doxorubicin, Hydroxychloroquine, Anticancer, Lung cancer

scholarly journals Photoinduced anticancer effect evaluation of ruthenium(II) polypyridyl complexes toward human lung cancer A549 cells

Polyhedron ◽  
2019 ◽  
Vol 165 ◽  
pp. 97-110 ◽  
Author(s):  
Miao He ◽  
Fan Du ◽  
Wen-Yao Zhang ◽  
Qiao-Yan Yi ◽  
Yang-Jie Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Human Lung ◽  
A549 Cells ◽  
Human Lung Cancer ◽  
Effect Evaluation ◽  
Anticancer Effect ◽  
Polypyridyl Complexes

ABCA3 mutations influence the stress level and immunological function of lung epithelial A549 cells

Pneumologie ◽  
2010 ◽  
Vol 64 (01) ◽  
Author(s):  
E Kaltenborn ◽  
L Fragnet ◽  
KK Konzelmann ◽  
N Weichert ◽  
M Griese ◽  
...  
Keyword(s):  
Stress Level ◽  
A549 Cells ◽  
Immunological Function ◽  
Lung Epithelial

Blocking of CDK4 Gene Expression by Antisense Oligos Induce Apoptosis and Decreases the Proliferation of A549 Cells

2012 ◽  
Vol 2 (8) ◽  
pp. 51-53
Author(s):  
Babu R L Babu R L ◽  
◽  
Vijayalakshmi E Vijayalakshmi E ◽  
Naveen Kumar M Naveen Kumar M ◽  
Rajeshwari H. Patil ◽  
...  
Keyword(s):  
Gene Expression ◽  
A549 Cells ◽  
Cdk4 Gene ◽  
Antisense Oligos
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