Tetrandrine inhibits cell migration and invasion in human nasopharyngeal carcinoma NPC‐TW 039 cells through inhibiting MAPK and RhoA signaling pathways

2020 ◽  
Vol 44 (10) ◽  
Author(s):  
Shin‐Hwar Wu ◽  
Fu‐Shin Chueh ◽  
Yu‐Cheng Chou ◽  
Yi‐Shih Ma ◽  
Shu‐Fen Peng ◽  
...  
Keyword(s):  
Cell Migration ◽  
Nasopharyngeal Carcinoma ◽  
Signaling Pathways ◽  
Migration And Invasion ◽  
Cell Migration And Invasion ◽  
Human Nasopharyngeal Carcinoma ◽  
Rhoa Signaling

Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways

2013 ◽  
Vol 387 (1-2) ◽  
pp. 101-111 ◽  
Author(s):  
Pei-Chien Tsai ◽  
Chiao-Lun Chu ◽  
Yaw-Syan Fu ◽  
Chih-Hua Tseng ◽  
Yeh-long Chen ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathways ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals Bornyl cis-4-Hydroxycinnamate Suppresses Cell Metastasis of Melanoma through FAK/PI3K/Akt/mTOR and MAPK Signaling Pathways and Inhibition of the Epithelial-to-Mesenchymal Transition

2018 ◽  
Vol 19 (8) ◽  
pp. 2152 ◽  
Author(s):  
Tzu-Yen Yang ◽  
Mei-Li Wu ◽  
Chi-I Chang ◽  
Chih-I Liu ◽  
Te-Chih Cheng ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathways ◽  
Melanoma Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion ◽  
Cell Metastasis ◽  
A375 Melanoma

Bornyl cis-4-hydroxycinnamate, a bioactive compound isolated from Piper betle stems, has the potential for use as an anti-cancer agent. This study investigated the effects of bornyl cis-4-hydroxycinnamate on cell migration and invasion in melanoma cells. Cell migration and invasion were compared in A2058 and A375 melanoma cell lines treated with/without bornyl cis-4-hydroxycinnamate (1–6 µM). To examine whether bornyl cis-4-hydroxycinnamate has a potential anti-metastatic effect on melanoma cells, cell migration and invasion assays were performed using a Boyden chamber assay and a transwell chamber in A2058 and A375 cells. Gelatin zymography was employed to determine the enzyme activities of MMP-2 and MMP-9. Cell lysates were collected for Western blotting analysis of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitors of metalloproteinase-1/2 (TIMP-1/2), as well as key molecules in the mitogen-activated protein kinase (MAPK), focal adhesion kinase (FAK)/ phosphatidylinositide-3 kinases (PI3K)/Akt/ mammalian target of rapamycin (mTOR), growth factor receptor-bound protein 2 (GRB2) signaling pathways. Our results demonstrated that bornyl cis-4-hydroxycinnamate is a potentially useful agent that inhibits melanoma cell migration and invasion, and altered melanoma cell metastasis by reducing MMP-2 and MMP-9 expression through inhibition of the FAK/PI3K/Akt/mTOR, MAPK, and GRB2 signaling pathways. Moreover, bornyl cis-4-hydroxycinnamate inhibited the process of the epithelial-to-mesenchymal transition in A2058 and A375 melanoma cells. These findings suggested that bornyl cis-4-hydroxycinnamate has potential as a chemotherapeutic agent, and warrants further investigation for its use in the management of human melanoma.

Leptin-induced signaling pathways in cancer cell migration and invasion

2019 ◽  
Vol 42 (3) ◽  
pp. 243-260 ◽  
Author(s):  
Ahmad Ghasemi ◽  
Jafar Saeidi ◽  
Mohsen Azimi-Nejad ◽  
Seyed Isaac Hashemy
Keyword(s):  
Cell Migration ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion

scholarly journals Downregulation of miR-429 and inhibition of cell migration and invasion in nasopharyngeal carcinoma

2016 ◽  
Vol 13 (4) ◽  
pp. 3236-3242 ◽  
Author(s):  
FANGZHENG WANG ◽  
CHUNER JIANG ◽  
QUANQUAN SUN ◽  
FENQIN YAN ◽  
LEI WANG ◽  
...  
Keyword(s):  
Cell Migration ◽  
Nasopharyngeal Carcinoma ◽  
Migration And Invasion ◽  
Cell Migration And Invasion
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