Phytochemical contents, antioxidant effects, and inhibitory activities of key enzymes associated with Alzheimer's disease, ulcer, and skin disorders of Sideritis albiflora and Sideritis leptoclada

2019 ◽  
Vol 43 (12) ◽  
Author(s):  
Ebru Deveci ◽  
Gülsen Tel‐Çayan ◽  
Mehmet Emin Duru ◽  
Mehmet Öztürk
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Skin Disorders ◽  
Key Enzymes ◽  
Inhibitory Activities ◽  
Antioxidant Effects ◽  
Phytochemical Contents

Two Ganoderma species: profiling of phenolic compounds by HPLC–DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders

2015 ◽  
Vol 6 (8) ◽  
pp. 2794-2802 ◽  
Author(s):  
Gokhan Zengin ◽  
Cengiz Sarikurkcu ◽  
Erdogan Gunes ◽  
Ahmet Uysal ◽  
Ramazan Ceylan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phenolic Compounds ◽  
Skin Disorders ◽  
Inhibitory Effects ◽  
Key Enzymes ◽  
Ganoderma Applanatum ◽  
Inhibitory Activities

We report the antioxidant, antimicrobial, and inhibitory effects of extracts from Ganoderma applanatum and G. resinaceum.

Coumarin, Anthroquinone and Stilbene Derivatives with Anticholinesterase Activity

2008 ◽  
Vol 63 (5-6) ◽  
pp. 366-370 ◽  
Author(s):  
Ilkay Orhan ◽  
Fatma Tosun ◽  
Bilge Şener
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spectrophotometric Method ◽  
Anticholinesterase Activity ◽  
Cholinergic Transmission ◽  
Coumarin Derivatives ◽  
Key Enzymes ◽  
Stilbene Derivatives ◽  
Microplate Reader ◽  
Inhibitory Activities

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the key enzymes in pathogenesis of Alzheimer’s disease (AD), which is characterized by a deficit in central cholinergic transmission. In the current study, AChE and BChE inhibitory activities of seven coumarin derivatives [umbelliferone (1), 4-methylumbelliferone (2), 4-hydroxycoumarin (3), scopoletin (4), 8-methoxypsoralen (5), bergapten (6), and iso-bergapten (7)], a furanocoumarin mixture obtained from Heracleum crenatifolium Boiss. (Umbelliferae), as well as of two anthroquinone derivatives [rhein (8) and aloe-emodine (9)] and one stilbene, rhapontin (10), were tested by the spectrophotometric method of Ellman using an ELISA microplate-reader at 1 mg mL-1. Among them, the furanocoumarin mixture [(68.8 ± 0.76)%], bergapten [(62.4 ± 0.74)%], aloe-emodine [(57.2 ± 1.32)%], scopoletin [(53.1 ± 0.83)%], and 4-methylumbelliferone [(62.3 ± 1.03)%] showed over 50% inhibition against AchE, while umbelliferone [(54.3 ± 0.23)%], 4-methylumbelliferone [(80.9 ± 1.17)%], scopoletin [(73.5 ± 1.01)%], 8-methoxypsoralen [(67.1 ± 0.98)%], as well as the furanocoumarin mixture [(76.7 ± 0.95)%] had a notable anti-BChE effect.

scholarly journals ANTINEURODEGENERATIVE ACTIVITY OF MICROALGAE DUNALIELLA SALINA IN RATS WITH ALZHEIMER’S DISEASE

2016 ◽  
Vol 10 (1) ◽  
pp. 134 ◽  
Author(s):  
Farouk Kamel Elbaz ◽  
Hanan F Aly ◽  
Wagdy Kb Khalil ◽  
Hoda F Booles ◽  
Gamila H Al
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurotrophic Factor ◽  
Dunaliella Salina ◽  
Brain Derived Neurotrophic Factor ◽  
Male Rats ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
The Brain ◽  
Antioxidant Effects

ABSTRACTObjective: The present study is aimed to investigate the promising action of Dunaliella salina extract as a natural protector against Alzheimer’sdisease (AD) and reported to possess a variety of activities, including antioxidant effects due to its ability to create large amount of carotenoids.Methods: D. salina is a type of halophile green microalgae was used in the present study. 50 male rats were used in this study, where aluminumchloride was orally administered to induce AD in a dose of 100 mg/kg, daily for 6 weeks. Al-intoxicated rats treated orally daily with D. salinaethanolic extract for 6 weeks in a dose of 150 mg/kg b.wt., whereas standard anti-Alzheimer drug donepezil tartrate was administered at the doseof 10 mg/kg b.wt./day for 6 consecutive weeks. The anti-Alzheimer properties of D. salina extract were achieved through measuring the calmodulin(CaM) level, paraoxonase 1 (PON1) activity, the antiapoptotic marker (Bcl2), brain-derived neurotrophic factor (BDNF), the generation of the DNAadducts (8-hydroxy-2-deoxyguanosine [8-OHdG]/2-deoxy guanosine [2-dG]), and alteration in the expression of amyloid precursor protein, β-siteAPP-cleaving enzyme 1 (BACE1), and β-site APP-cleaving enzyme 2 (BACE2) in AD rats.Results: The current results demonstrated that supplementation of AD rats with D. salina extract-enhanced CaM level, and increased PON1 activity,upregulated Bcl2 and BDNF, decreased the levels of DNA adducts (8-OHdG/2-dG), and suppressed the alterations of the expression levels of APP,BACE1, and BACE2-m RNAs as compared with those in AD rats.Conclusion: It could be concluded that the biological activity of D. salina extract might be regulated by 9-cis b-carotene protecting the brain cells fromthe oxidative stress in AD rats.Keywords: Dunaliella salina, Calmodulin, Paraoxonase 1, Bcl2, Brain-derived neurotrophic factor, Alzheimer’s disease, DNA adduct, Amyloid precursorprotein.

Multifunctional quinoxaline-hydrazone derivatives with acetylcholinesterase and monoamine oxidases inhibitory activities as potential agents against Alzheimer’s disease

2020 ◽  
Vol 29 (6) ◽  
pp. 1000-1011 ◽  
Author(s):  
Ulviye Acar Çevik ◽  
Derya Osmaniye ◽  
Begüm Nurpelin Sağlik ◽  
Betül Kaya Çavuşoğlu ◽  
Serkan Levent ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Monoamine Oxidases ◽  
Inhibitory Activities

scholarly journals Asperterpenes A and B, two unprecedented meroterpenoids from Aspergillus terreus with BACE1 inhibitory activities

2016 ◽  
Vol 7 (10) ◽  
pp. 6563-6572 ◽  
Author(s):  
Changxing Qi ◽  
Jian Bao ◽  
Jianping Wang ◽  
Hucheng Zhu ◽  
Yongbo Xue ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Activity ◽  
Aspergillus Terreus ◽  
Inhibitory Activities

Asperterpenes A and B, two BACE1 inhibitors with unprecedented carbon skeletons isolated fromAspergillus terreus, exhibit potent anti-Alzheimer's disease activity.

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