Two Ganoderma species: profiling of phenolic compounds by HPLC–DAD, antioxidant, antimicrobial and inhibitory activities on key enzymes linked to diabetes mellitus, Alzheimer's disease and skin disorders

2015 ◽  
Vol 6 (8) ◽  
pp. 2794-2802 ◽  
Author(s):  
Gokhan Zengin ◽  
Cengiz Sarikurkcu ◽  
Erdogan Gunes ◽  
Ahmet Uysal ◽  
Ramazan Ceylan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Phenolic Compounds ◽  
Skin Disorders ◽  
Inhibitory Effects ◽  
Key Enzymes ◽  
Ganoderma Applanatum ◽  
Inhibitory Activities

We report the antioxidant, antimicrobial, and inhibitory effects of extracts from Ganoderma applanatum and G. resinaceum.

Coumarin, Anthroquinone and Stilbene Derivatives with Anticholinesterase Activity

2008 ◽  
Vol 63 (5-6) ◽  
pp. 366-370 ◽  
Author(s):  
Ilkay Orhan ◽  
Fatma Tosun ◽  
Bilge Şener
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Spectrophotometric Method ◽  
Anticholinesterase Activity ◽  
Cholinergic Transmission ◽  
Coumarin Derivatives ◽  
Key Enzymes ◽  
Stilbene Derivatives ◽  
Microplate Reader ◽  
Inhibitory Activities

Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the key enzymes in pathogenesis of Alzheimer’s disease (AD), which is characterized by a deficit in central cholinergic transmission. In the current study, AChE and BChE inhibitory activities of seven coumarin derivatives [umbelliferone (1), 4-methylumbelliferone (2), 4-hydroxycoumarin (3), scopoletin (4), 8-methoxypsoralen (5), bergapten (6), and iso-bergapten (7)], a furanocoumarin mixture obtained from Heracleum crenatifolium Boiss. (Umbelliferae), as well as of two anthroquinone derivatives [rhein (8) and aloe-emodine (9)] and one stilbene, rhapontin (10), were tested by the spectrophotometric method of Ellman using an ELISA microplate-reader at 1 mg mL-1. Among them, the furanocoumarin mixture [(68.8 ± 0.76)%], bergapten [(62.4 ± 0.74)%], aloe-emodine [(57.2 ± 1.32)%], scopoletin [(53.1 ± 0.83)%], and 4-methylumbelliferone [(62.3 ± 1.03)%] showed over 50% inhibition against AchE, while umbelliferone [(54.3 ± 0.23)%], 4-methylumbelliferone [(80.9 ± 1.17)%], scopoletin [(73.5 ± 1.01)%], 8-methoxypsoralen [(67.1 ± 0.98)%], as well as the furanocoumarin mixture [(76.7 ± 0.95)%] had a notable anti-BChE effect.

scholarly journals Shared Blood Transcriptomic Signatures between Alzheimer’s Disease and Diabetes Mellitus

Biomedicines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 34
Author(s):  
Taesic Lee ◽  
Hyunju Lee
Keyword(s):  
Diabetes Mellitus ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Interactions ◽  
Expression Patterns ◽  
Protein Protein Interactions ◽  
Hub Genes ◽  
Gene Modules ◽  
Gene Regulatory ◽  
The Brain

Alzheimer’s disease (AD) and diabetes mellitus (DM) are known to have a shared molecular mechanism. We aimed to identify shared blood transcriptomic signatures between AD and DM. Blood expression datasets for each disease were combined and a co-expression network was used to construct modules consisting of genes with similar expression patterns. For each module, a gene regulatory network based on gene expression and protein-protein interactions was established to identify hub genes. We selected one module, where COPS4, PSMA6, GTF2B, GTF2F2, and SSB were identified as dysregulated transcription factors that were common between AD and DM. These five genes were also differentially co-expressed in disease-related tissues, such as the brain in AD and the pancreas in DM. Our study identified gene modules that were dysregulated in both AD and DM blood samples, which may contribute to reveal common pathophysiology between two diseases.

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