Moringa oleiferaseed oil or virgin coconut oil supplementation abrogates cerebral neurotoxicity induced by antineoplastic agent methotrexate by suppression of oxidative stress and neuro‐inflammation in rats

2018 ◽  
pp. e12748 ◽  
Author(s):  
Ademola C. Famurewa ◽  
Patrick M. Aja ◽  
Onyebuchi E. Nwankwo ◽  
Joshua N. Awoke ◽  
Ekenechukwu K. Maduagwuna ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antineoplastic Agent ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Neuro Inflammation

scholarly journals Enhanced memory in Wistar rats by virgin coconut oil is associated with increased antioxidative, cholinergic activities and reduced oxidative stress

2017 ◽  
Vol 55 (1) ◽  
pp. 825-832 ◽  
Author(s):  
Nur Syafiqah Rahim ◽  
Siong Meng Lim ◽  
Vasudevan Mani ◽  
Abu Bakar Abdul Majeed ◽  
Kalavathy Ramasamy
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Coconut Oil ◽  
Virgin Coconut Oil

scholarly journals The protective role of virgin coconut oil on the alloxan-induced oxidative stress in the liver, kidneys and heart of diabetic rats

2019 ◽  
Vol 10 (4) ◽  
pp. 2114-2124 ◽  
Author(s):  
Siniša Đurašević ◽  
Nebojša Jasnić ◽  
Marko Prokić ◽  
Ilijana Grigorov ◽  
Vesna Martinović ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coconut Oil ◽  
Protective Role ◽  
Diabetic Rats ◽  
Toxic Effects ◽  
Virgin Coconut Oil ◽  
Tissue Specific

Our results show that VCO supplementation ameliorates some toxic effects of alloxan induced diabetes, and that the changes are tissue specific.

scholarly journals Virgin Coconut Oil Ameliorates Colchicine Induced Cognitive Dysfunction- A Preclinical Study

2020 ◽  
Vol 26 (1) ◽  
pp. 1-12
Author(s):  
Jeena John ◽  
Naveen Kumar Sapa ◽  
Rekha R Shenoy
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Frontal Cortex ◽  
Cognitive Dysfunction ◽  
Unsaturated Fatty Acids ◽  
Ketone Bodies ◽  
Coconut Oil ◽  
Treated Group ◽  
Virgin Coconut Oil ◽  
Neuroprotective Effects

Background : Virgin coconut oil (VCO) has been identified as a potential cognitive strengthener associated with Alzheimer’s disease (AD). It contains medium chain fatty acids (MCFA) which are absorbed and easily metabolized by the liver to form ketone bodies. Ketone bodies are converted to acetyl Co-A in the brain which then enters the citric acid cycle to provide ATP and also serves as precursors of acetylcholine in neurons. Sunflower oil (SO) contains poly unsaturated fatty acids which has both anti-inflammatory and neuroprotective actions. To compare the neuroprotective effects of VCO and SO on biochemical parameters involved in the cognitive dysfunction induced by colchicine through intracerebroventricular (i.c.v) route.To assess the role of polyphenols and MCFA present in VCO in preventing oxidative stress and its influence on in neuroprotection and memory enhancement. Methods: In the present study, we induced dementia through i.c.v injection of colchicine after giving the diet enriched VCO and SO in rats for 60 days. Rats were sacrificed on the 22nd day after the administration of colchicine. Behavioral parameters were assessed during the study period and biochemical estimations were performed using frontal cortex and hippocampus isolated from rat brain. Results: From the memory and learning tests by Morris water maze, VCO treated group performed better than SO treated rats. VCO reversed the antagonistic effects induced by colchicine by decreasing the acetylcholinesterase and malondialdehyde levels and increasing the levels of catalase and superoxide dismutase. SO only reduced malondialdehyde levels in cortex and hippocampus. Conclusion: The results demonstrated potential beneficiary effects of VCO in the cognitive dysfunction induced by colchicine by enhancing acetylcholine levels in the frontal cortex and hippocampus and also by reducing oxidative stress induced by physiological oxidants.

scholarly journals ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF VIRGIN COCONUT OIL AT MAXIMUM PHYSICAL ACTIVITY

2019 ◽  
pp. 272-276 ◽  
Author(s):  
FAJAR APOLLO SINAGA ◽  
URIP HARAHAP ◽  
JANSEN SILALAHI ◽  
HERBERT SIPAHUTAR
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Transaminase Level ◽  
Coconut Oil ◽  
Male Rats ◽  
Antioxidant Defenses ◽  
Control Group ◽  
Time To Exhaustion ◽  
Protective Effects ◽  
Virgin Coconut Oil

Objective: The purpose of this study was to determine the protective effects of virgin coconut oil (VCO) treatment on hepatic oxidative stress and antioxidant defenses after maximum physical activity. Methods: This study used 24 healthy male rats. The rats were divided into four groups randomly consisted of six rats in each group. The control group (P0) was given 2 mL water, the treatment groups (VCO-1, VCO-2, and VCO-4) were given VCO 1 ml/200 g BW, 2 ml/200 g BW, and 4 ml/200 g BW, respectively, per day using gavage spuit. The rats were trained to swim for a month, 30 min/day in the 1st week, 35 min/day in the 2nd week, 40 min/ day in the 3rd week, and 45 min/day in the 4th week. After 28 days, the rats were forced to perform the maximal activity by putting the rats in water with no exit. Blood samples were collected immediately after the maximum physical activity, and then, all rats were killed and liver tissues were collected. The malondialdehyde (MDA), glutathione peroxidase (GPx), and serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvate transaminase level were then measured. Results: VCO increased swimming time to exhaustion, levels of GPx in the liver, which were accompanied by corresponding decreases in the MDA, alanine transaminase, and aspartate transaminase content. Conclusion: The results from this study indicate that VCO is effective in the prevention of oxidative stress following maximum physical activity.

scholarly journals Virgin Coconut Oil Resists Arsenic-Induced Cerebral Neurotoxicity and Cholesterol Imbalance via Suppression of Oxidative Stress, Adenosine Deaminase and Acetylcholinesterase Activities in Rats

2021 ◽  
Vol 16 (6) ◽  
pp. 1934578X2110169
Author(s):  
Sharon O. Azubuike-Osu ◽  
Ademola C. Famurewa ◽  
Japheth C. David ◽  
Innocent Abi ◽  
Patience N. Ogbu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Adenosine Deaminase ◽  
Normal Control ◽  
Coconut Oil ◽  
Histopathological Study ◽  
Virgin Coconut Oil ◽  
Oral Gavage ◽  
Once Daily ◽  
Biochemical Alterations

Arsenic (As) is a classic neurotoxicant; its pathogenesis is associated with oxidative stress and oxidative stress-mediated cholinergic deficits. This study explored antioxidant activity of virgin coconut oil (VCO) against sodium arsenite-induced oxidative stress-mediated cerebral neurotoxicity in rats. Eighteen rats were divided into 3 groups- Normal control, As control and VCO + As. The VCO (5 mL/kg) was given once daily by oral gavage from day 1 to day 21, while As (10 mg/kg) was given once daily by oral gavage from day 15 to day 21. Cerebral superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA), adenosine deaminase (ADA) and acetylcholinesterase (AchE) activities were analysed. Nitric oxide (NO), lipid profile, phospholipid (PL), and reduced glutathione (GSH) were also evaluated in cerebral homogenate. The cerebrum was sectioned for histological analysis. Administration of As induced significant depressions in antioxidant enzymes, GSH, PL, and HDL-c compared to normal control. Levels of MDA, NO, total cholesterol and activities of ADA, AchE in the cerebrum were markedly increased by As compared to normal rats. Lipid profile indices and PL were prominently altered by As. Histopathological study supported the biochemical findings through extensive cerebral damage. In contrast, oral supplementation of VCO prior to and along with As treatment significantly attenuated the As-induced biochemical alterations and restored near-normal histology. VCO attenuates cerebral neurotoxicity by strengthening endogenous antioxidant defence and cholinergic function via counteracting free-radical-mediated arsenic toxicity.

scholarly journals Antioxidant and anti-inflammatory mechanisms of polyphenols isolated from virgin coconut oil attenuate cadmium-induced oxidative stress-mediated nephrotoxicity and inflammation in rats

2018 ◽  
Vol 16 (4) ◽  
pp. 281-288 ◽  
Author(s):  
Ademola C. Famurewa ◽  
Abumchukwu J. Ejezie ◽  
Chioma S. Ugwu-Ejezie ◽  
Ebele J. Ikekpeazu ◽  
Fidelis E. Ejezie
Keyword(s):  
Oxidative Stress ◽  
Coconut Oil ◽  
Virgin Coconut Oil ◽  
Anti Inflammatory
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