Anticancer activity and mechanism of action of fermented wheat germ extract against ovarian cancer

2018 ◽  
Vol 42 (6) ◽  
pp. e12688 ◽  
Author(s):  
Eun Mi Koh ◽  
Eun Kyeong Lee ◽  
Jeongah Song ◽  
Su Jin Kim ◽  
Chi Hun Song ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Anticancer Activity ◽  
Mechanism Of Action ◽  
Wheat Germ ◽  
Wheat Germ Extract ◽  
Fermented Wheat Germ Extract

scholarly journals Characterizing the Efficacy of Fermented Wheat Germ Extract Against Ovarian Cancer and Defining the Genomic Basis of Its Activity

2012 ◽  
Vol 22 (6) ◽  
pp. 960-967 ◽  
Author(s):  
Patricia L. Judson ◽  
Entidhar Al Sawah ◽  
Douglas C. Marchion ◽  
Yin Xiong ◽  
Elona Bicaku ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Wheat Germ ◽  
Human Cancer ◽  
Expression Data ◽  
Wheat Germ Extract ◽  
Antiproliferative Effects ◽  
Genome Wide ◽  
Fermented Wheat Germ Extract ◽  
Ovca Cell

ObjectiveMost women with advanced-stage epithelial ovarian cancer (OVCA) ultimately develop chemoresistant recurrent disease. Therefore, a great need to develop new, more active, and less toxic agents and/or to optimize the efficacy of existing agents exists.MethodsIn this study, we investigated the activity of Avemar, a natural, nontoxic, fermented wheat germ extract (FWGE), against a range of OVCA cell lines, both alone and in combination with cisplatin chemotherapy and delineated the molecular signaling pathways that underlie FWGE activity at a genome-wide level.ResultsWe found that FWGE exhibited significant antiproliferative effects against 12 human OVCA cell lines and potentiated cisplatin-induced apoptosis. Pearson correlation of FWGE sensitivity and gene expression data identified 2142 genes (false discovery rate < 0.2) representing 27 biologic pathways (P< 0.05) to be significantly associated with FWGE sensitivity. A parallel analysis of genomic data for 59 human cancer cell lines matched to chemosensitivity data for 2,6-dimethoxy-p-benzoquinone, a proposed active component of FWGE, identified representation of 13 pathways common to both FWGE and 2,6-dimethoxy-p-benzoquinone sensitivity.ConclusionsOur findings confirm the value of FWGE as a natural product with anticancer properties that may also enhance the activity of existing therapeutic agents. Furthermore, our findings provide substantial insights into the molecular basis of FWGE’s effect on human cancer cells.Research HighlightsFermented wheat germ extract has significant antiproliferative effects on OVCA cell lines and may enhance the effect of cisplatin-induced cell death.Genome-wide expression data reveal that FWGE sensitivity in ovarian cancer cells was associated with 2142 genes, representing 27 biologic pathways.The known safety and tolerability of FWGE supports the clinical evaluation of this natural product in patients with ovarian cancer.

scholarly journals Fermented Wheat Germ Extract Induced Cell Death and Enhanced Cytotoxicity of Cisplatin and 5-Fluorouracil on Human Hepatocellular Carcinoma Cells

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Cheng-Jeng Tai ◽  
Wen-Ching Wang ◽  
Chien-Kai Wang ◽  
Chih-Hsiung Wu ◽  
Mei-Due Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Death ◽  
Wheat Germ ◽  
Adenosine Diphosphate ◽  
Chemotherapeutic Agents ◽  
Current Therapy ◽  
Wheat Germ Extract ◽  
Combination Drug ◽  
Fermented Wheat Germ Extract ◽  
Hcc Cells

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Due to the difficulties of early diagnosis, curative treatments are not available for most patients. Palliative treatments such as chemotherapy are often associated with low response rate, strong adverse effects and limited clinical benefits for patients. The alternative approaches such as fermented wheat germ extract (FWGE) with anti-tumor efficacy may provide improvements in the clinical outcome of current therapy for HCC. This study aimed to clarify antitumor efficacy of FWGE and the combination drug effect of FWGE with chemotherapeutic agents, cisplatin and 5-fluorouracil (5-Fu) in human HCC cells, HepG2, Hep3B, and HepJ5. The present study indicated that FWGE exhibited potential to suppress HepG2, Hep3B, and HepJ5 cells, with the half maximal inhibitory concentrations (IC50) of FWGE were 0.494, 0.371 and 1.524 mg/mL, respectively. FWGE also induced Poly (Adenosine diphosphate ribose) polymerase (PARP) associated cell death in Hep3B cells. Moreover, the FWGE treatment further enhanced the cytotoxicity of cisplatin in all tested HCC cells, and cytotoxicity of 5-Fu in a synergistic manner in HepJ5 cells. Collectively, the results identified the anti-tumor efficacy of FWGE in HCC cells and suggested that FWGE can be used as a supplement to effectively improve the tumor suppression efficiency of cisplatin and 5-Fu in HCC cells.

scholarly journals Fermented Wheat Germ Extract Inhibits Glycolysis/Pentose Cycle Enzymes and Induces Apoptosis through Poly(ADP-ribose) Polymerase Activation in Jurkat T-cell Leukemia Tumor Cells

2002 ◽  
Vol 277 (48) ◽  
pp. 46408-46414 ◽  
Author(s):  
Begoña Comı́n-Anduix ◽  
László G. Boros ◽  
Silvia Marin ◽  
Joan Boren ◽  
Carles Callol-Massot ◽  
...  
Keyword(s):  
T Cell ◽  
Tumor Cells ◽  
Wheat Germ ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Wheat Germ Extract ◽  
Jurkat T Cell ◽  
Fermented Wheat Germ Extract

Fermented Wheat Germ Extract Reduces Chemotherapy-Induced Febrile Neutropenia in Pediatric Cancer Patients

2004 ◽  
Vol 26 (10) ◽  
pp. 631-635 ◽  
Author(s):  
Miklós Garami ◽  
Dezső Schuler ◽  
Mária Babosa ◽  
Gábor Borgulya ◽  
Péter Hauser ◽  
...  
Keyword(s):  
Febrile Neutropenia ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Wheat Germ ◽  
Wheat Germ Extract ◽  
Pediatric Cancer Patients ◽  
Fermented Wheat Germ Extract
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