Sichuan pepper attenuates H2O2-induced apoptosis via antioxidant activity and up-regulating heme oxygenase-1 gene expression in primary rat hepatocytes

2017 ◽  
Vol 41 (6) ◽  
pp. e12403 ◽  
Author(s):  
Huan Zhang ◽  
Xuelin Zhou ◽  
Marcus Ho-Yin Wong ◽  
Ka-Yi Man ◽  
Wing-Kwan Pin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antioxidant Activity ◽  
Heme Oxygenase ◽  
Rat Hepatocytes ◽  
Heme Oxygenase 1 ◽  
Primary Rat Hepatocytes ◽  
Induced Apoptosis

Expression of the mRNA of Heme-Binding Protein 23 Is Coordinated with That of Heme Oxygenase-1 by Heme and Heavy Metals in Primary Rat Hepatocytes and Hepatoma Cells

Biochemistry ◽  
1995 ◽  
Vol 34 (41) ◽  
pp. 13407-13411 ◽  
Author(s):  
Stephan Immenschuh ◽  
Shin-ichiro Iwahara ◽  
Hiroyuki Satoh ◽  
Christina Nell ◽  
Norbert Katz ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Heme Oxygenase ◽  
Binding Protein ◽  
Rat Hepatocytes ◽  
Hepatoma Cells ◽  
Heme Oxygenase 1 ◽  
Heme Binding ◽  
Primary Rat Hepatocytes ◽  
Heme Binding Protein

scholarly journals Induction of heme oxygenase-1 and heat shock protein 70 in rat hepatocytes: The role of calcium signaling

2007 ◽  
Vol 12 (1) ◽  
Author(s):  
Malte Silomon ◽  
Inge Bauer ◽  
Michael Bauer ◽  
Julia Nolting ◽  
Markus Paxian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stress Response ◽  
Heat Shock ◽  
Heme Oxygenase ◽  
Rat Hepatocytes ◽  
Glutathione Depletion ◽  
Heme Oxygenase 1 ◽  
Hsp70 Gene ◽  
Stress Response Genes

AbstractStress response genes including heat shock proteins are induced under a variety of conditions to confer cellular protection. This study investigated the role of calcium signaling in the induction of two stress response genes, heme oxygenase-1/hsp32 and hsp70, in isolated rat hepatocytes. Both genes were induced by cellular glutathione depletion. This induction could be inhibited by BAPTA-AM. Culturing in a calcium-free medium prevented the induction of hsp70 gene expression after glutathione depletion without affecting heme oxygenase-1 gene expression. Thapsigargin increased the gene expression of heme oxygenase-1 but not that of hsp70. Thapsigargin-induced heme oxygenase-1 induction was completely inhibited by BAPTA-AM. Incubation with the Ca2+-ionophore A23187 augmented heme oxygenase-1 (two-fold) and hsp70 (5.2-fold) mRNA levels. Our data suggests a significant role of Ca2+-dependent pathways in the induction of the two stress genes. An increase in the cytoplasmic Ca2+ activity seems to play a key role in the cascade of signaling leading to the induction of the two genes. However, the source of Ca2+ that fluxes into the cytoplasm seems to be different. Our data provides evidence for a compartmentalization of calcium fluxes, i.e. the Ca2+ flux from intracellular stores (e.g. the endoplasmic reticulum) plays a major role in the induction of heme oxygenase-1. By contrast, Ca2+ flux from the extracellular medium seems to be a mechanism initiating the cellular signaling cascade leading to hsp70 gene induction.

scholarly journals Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression

2007 ◽  
Vol 1773 (7) ◽  
pp. 1073-1086 ◽  
Author(s):  
Hui-Yi Lin ◽  
Shing-Chuan Shen ◽  
Cheng-Wei Lin ◽  
Liang-Yo Yang ◽  
Yen-Chou Chen
Keyword(s):  
Gene Expression ◽  
Hydrogen Peroxide ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Induced Apoptosis

Modulation of the Heme Oxygenase HO-1 Expression by Hyperosmolarity and Betaine in Primary Rat Hepatocytes

2001 ◽  
Vol 388 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Mohammad R. Lordnejad ◽  
Freimut Schliess ◽  
Matthias Wettstein ◽  
Dieter Häussinger
Keyword(s):  
Heme Oxygenase ◽  
Rat Hepatocytes ◽  
Primary Rat Hepatocytes

Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition

2012 ◽  
Vol 420 (2) ◽  
pp. 288-292 ◽  
Author(s):  
Woo-Kwang Jeon ◽  
Hey-Young Hong ◽  
Won-Chan Seo ◽  
Kyu-Hyoung Lim ◽  
Hui-Young Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Lung Cancer Cells ◽  
Heme Oxygenase 1 ◽  
Induced Apoptosis ◽  
A549 Lung
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