Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition

2012 ◽  
Vol 420 (2) ◽  
pp. 288-292 ◽  
Author(s):  
Woo-Kwang Jeon ◽  
Hey-Young Hong ◽  
Won-Chan Seo ◽  
Kyu-Hyoung Lim ◽  
Hui-Young Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Lung Cancer Cells ◽  
Heme Oxygenase 1 ◽  
Induced Apoptosis ◽  
A549 Lung

The Effect of Inhibition of Heme Oxygenase-1 on Chemosensitivity of Cisplatin in Lung Cancer Cells

2007 ◽  
Vol 62 (1) ◽  
pp. 33 ◽  
Author(s):  
So-Young Kim ◽  
Eun-Jung Kim ◽  
Hye-Yeon Jang ◽  
Ki-Eun Hwang ◽  
Jung-Hyun Park ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Lung Cancer Cells ◽  
Heme Oxygenase 1

scholarly journals Heme Oxygenase-1 via Transcriptional Activation of Nrf2 Attenuates Apoptosis in Lung Cancer Cells

2006 ◽  
Vol 5 (1) ◽  
pp. 39
Author(s):  
Hak-Ryul Kim ◽  
Eun-Jung Kim ◽  
Ki-Eun Hwang ◽  
So-Young Kim ◽  
Seong-Hoon Park ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Heme Oxygenase ◽  
Transcriptional Activation ◽  
Lung Cancer Cells ◽  
Heme Oxygenase 1

Glossogin, a novel phenylpropanoid from Glossogyne tenuifolia, induced apoptosis in A549 lung cancer cells

2008 ◽  
Vol 46 (12) ◽  
pp. 3785-3791 ◽  
Author(s):  
Hsia-Fen Hsu ◽  
Jer-Yiing Houng ◽  
Chih-Feng Kuo ◽  
Nina Tsao ◽  
Yang-Chang Wu
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Induced Apoptosis ◽  
Glossogyne Tenuifolia ◽  
A549 Lung

scholarly journals Shikonin Induces Apoptosis, Necrosis, and Premature Senescence of Human A549 Lung Cancer Cells through Upregulation of p53 Expression

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Yueh-Chiao Yeh ◽  
Tsun-Jui Liu ◽  
Hui-Chin Lai
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Cell Fate ◽  
Specific Inhibitor ◽  
Lung Cancer Cells ◽  
Premature Senescence ◽  
Dependent Manner ◽  
P53 Expression ◽  
Induced Apoptosis ◽  
A549 Lung

Shikonin, a natural naphthoquinone pigment isolated fromLithospermum erythrorhizon, has been reported to suppress growth of various cancer cells. This study was aimed to investigate whether this chemical could also inhibit cell growth of lung cancer cells and, if so, works via what molecular mechanism. To fulfill this, A549 lung cancer cells were treated with shikonin and then subjected to microscopic, biochemical, flow cytometric, and molecular analyses. Compared with the controls, shikonin significantly induced cell apoptosis and reduced proliferation in a dose-dependent manner. Specially, lower concentrations of shikonin (1–2.5 μg/mL) cause viability reduction; apoptosis and cellular senescence induction is associated with upregulated expressions of cell cycle- and apoptotic signaling-regulatory proteins, while higher concentrations (5–10 μg/mL) precipitate both apoptosis and necrosis. Treatment of cells with pifithrin-α, a specific inhibitor of p53, suppressed shikonin-induced apoptosis and premature senescence, suggesting the role of p53 in mediating the actions of shikonin on regulation of lung cancer cell proliferation. These results indicate the potential and dose-related cytotoxic actions of shikonin on A549 lung cancer cells via p53-mediated cell fate pathways and raise shikonin a promising adjuvant chemotherapeutic agent for treatment of lung cancer in clinical practice.

scholarly journals Effect of autophagy inhibition on chemotherapy-induced apoptosis in A549 lung cancer cells

2013 ◽  
Vol 5 (4) ◽  
pp. 1261-1265 ◽  
Author(s):  
FEIFEI LIU ◽  
DONGLEI LIU ◽  
YANG YANG ◽  
SONG ZHAO
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Induced Apoptosis ◽  
Autophagy Inhibition ◽  
A549 Lung
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