Vasorelaxant and Anti-Inflammatory Activities of the Methylene Chloride Fraction of F oeniculum vulgare Fruit Extract

2015 ◽  
Vol 39 (1) ◽  
pp. 55-63 ◽  
Author(s):  
C.O. Tettey ◽  
I. Yang ◽  
A. Ocloo ◽  
H.M. Shin
Keyword(s):  
Methylene Chloride ◽  
Fruit Extract ◽  
Anti Inflammatory ◽  
Methylene Chloride Fraction

scholarly journals Comprehensive Characterization of Lignans from Forsythia viridissima by UHPLC-ESI-QTOF-MS, and Their NO Inhibitory Effects on RAW 264.7 Cells

Molecules ◽  
2019 ◽  
Vol 24 (14) ◽  
pp. 2649
Author(s):  
Jungmoo Huh ◽  
Chang-Min Lee ◽  
Seoyoung Lee ◽  
Soeun Kim ◽  
Namki Cho ◽  
...  
Keyword(s):  
Methylene Chloride ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Inhibitory Effects ◽  
Detection And Identification ◽  
Anti Inflammatory ◽  
Lignan Glycosides ◽  
Fragmentation Patterns ◽  
Oxide Synthase ◽  
Methylene Chloride Fraction

Lignans are known to be an important class of phenylpropanoid secondary metabolites. In the course of our studies on the chemodiversity of lignans, the necessity arose to develop a method for the fast detection and identification of bioactive lignan subclasses. In this study, we detected 10 lignan derivatives of different extracts of F. viridissima by UHPLC-ESI-QTOF-MS. Lignan glycosides (1 and 2), lignans (3 and 4), and lignan dimers (5–10) were identified by analysis of their exact masses and MSe spectra along with the characteristic mass fragmentation patterns and molecular formulas. We further investigated NO inhibitory effects of F. viridissima fractions and their major lignan derivatives to evaluate those anti-inflammatory effects. The methylene chloride fraction of F. viridissima as well as compounds 8 and 10 showed potent dose-dependent NO inhibitory effects on RAW 264.7 cells. Corresponding to the NO inhibition by compounds 8 and 10, lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression was notably reduced by both compounds. Our combined data with the bioactive results and the component analysis by UHPLC-ESI-QTOF-MS suggest that the methylene chloride fraction of F. viridissima roots could be potential anti-inflammatory agents and these are related to major lignans including dimeric dibenzylbutyrolactone lignans.

scholarly journals Mechanisms of Analgesic and Anti-Inflammatory Properties of Annona muricata Linn. (Annonaceae) Fruit Extract in Rodents

2014 ◽  
Vol 17 (12) ◽  
pp. 1375-1382 ◽  
Author(s):  
Ismail O. Ishola ◽  
Olufunsho Awodele ◽  
Abayomi Micheal Olusayero ◽  
Charles O. Ochieng
Keyword(s):  
Annona Muricata ◽  
Fruit Extract ◽  
Anti Inflammatory

Evaluation of Momordica charantia L. Fruit Extract for Analgesic and Anti-inflammatory activities using in vivo Assay

2012 ◽  
Vol 6 (3) ◽  
pp. 236-244 ◽  
Author(s):  
M. Ullah ◽  
Mir Showkat ◽  
Nazim Uddin Ahme ◽  
Saiful Islam ◽  
Nurul Absar
Keyword(s):  
Momordica Charantia ◽  
Fruit Extract ◽  
In Vivo Assay ◽  
Anti Inflammatory

scholarly journals ASSESSMENT OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF ASAM KANDIS (GARCINIA XANTHOCHYMUS HOOK. F. EX T. ANDERSON) FRUIT

2018 ◽  
Vol 11 (4) ◽  
pp. 81
Author(s):  
Hanafis Sastra Winata ◽  
Rosidah Rosidah ◽  
Panal Sitorus
Keyword(s):  
Ethanolic Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Inflammatory Activity ◽  
Control Group ◽  
Phytochemical Screening ◽  
Fruit Extract ◽  
Garcinia Xanthochymus ◽  
Anti Inflammatory

 Objective: The objective of this study was to evaluate the anti-inflammatory activity in acute and subacute models of inflammation from ethanolic fruit extract of Asam kandis (Garcinia xanthochymus Hook. f. ex T. Anderson) in animal (rats) models.Methods: Pleliminary phytochemical screening was carried out by using standard procedures.. Assessment of acute and subacute models of inflammation was using carrageenan-induced paw edema method and cotton pellet granuloma method using three dosage treatments; 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW along with a negative control group (0.5% Na CMC) and positive control (Na diclofenac 2.25 mg/kg BW). The inhibition period was observed at 30, 60, 90, 120, 150, and 180 min time intervals.Result: The phytochemical screening showed that the ethanolic fruit extract from Asam kandis contain contains flavonoids, glycosides, steroids, and triterpenoids. The anti-inflammatory result showed that the strongest inhibition produced by ethanolic fruit extract of Asam kandis occurred on the dosage of 800 mg/kg BW compared to the other doses (200 and 400 mg/kg BW) throughout the observation period.Conclusion: This finding indicated that ethanolic fruit extract of Asam kandis (G. xanthochymus Hook. f. ex T. Anderson) might become an interesting candidate for treatment of inflammation.

scholarly journals CACTUS PEAR FRUIT EXTRACT EXERTS ANTI-INFLAMMATORY EFFECTS IN CARRAGEENIN-INDUCED RAT PLEURISY

2015 ◽  
pp. 19-25
Author(s):  
M. Allegra ◽  
L. Tesoriere ◽  
M.A. Livrea ◽  
A. Ianaro ◽  
E. Panza
Keyword(s):  
Pear Fruit ◽  
Fruit Extract ◽  
Cactus Pear ◽  
Anti Inflammatory

Anti-proliferative, anti-inflammatory and anti-mutagenic activities of a Prunus mahaleb L. anthocyanin-rich fruit extract

2016 ◽  
Vol 27 ◽  
pp. 537-548 ◽  
Author(s):  
Carmela Gerardi ◽  
Stefania Frassinetti ◽  
Leonardo Caltavuturo ◽  
Antonella Leone ◽  
Raffaella Lecci ◽  
...  
Keyword(s):  
Fruit Extract ◽  
Prunus Mahaleb ◽  
Anti Inflammatory

scholarly journals The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.)

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Sara Nurmala ◽  
Moerfia Moerfia ◽  
Santi Novianti
Keyword(s):  
Wound Healing ◽  
Allium Cepa ◽  
The United States ◽  
Abelmoschus Esculentus ◽  
Male Rats ◽  
Cell Multiplication ◽  
Fruit Extract ◽  
White Rats ◽  
Allium Cepa L ◽  
Anti Inflammatory

Wound is a condition that is the destruction of the unity or network components, which are specifically found the substance of tissue damaged or lost, either damage the continuity of the skin, mucous membranes and bones or other organs. Wound healing is a very complex process involving many cells. The process of wound healing is portrayed as occurs in biological surgical wound occurred. Several phases of wound healing are: the process of inflammation (inflammatory), the process of cell multiplication (proliferation) and cell maturation process (maturase). Okra is a plant that allegedly came from Southeast Asia. Okra has grown in many countries in almost all over the world. In the UK okra known as the Lady's Finger, in India it is called by the name of Bhindi while the United States called Gumbo. In Indonesia, this plant also has a local name that is Rabamea (Bima), Coffee Java (Java), Arabian Coffee (Sulawesi), Hoinu (Southeast Sulawesi), but better known by the name of okra. This study aims to determine the effective concentration and determine the length of time of wound healing using a combination gel okra fruit extract (Abelmoschus esculentus) And shallots (Allium cepa L.) as an anti-inflammatory against cuts in male white rats (Sprague -Dawley) with a length of observation for 9 days. This study uses Betadine® ointment as a positive control. The results showed the combination of fruit extract gel okra 6% and shallots 2% contained in the formula 3 most effective as an anti-inflammatory against cuts in male rats by administration for 6 days.

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