Expression of koebnerisin (S100A15) and calgranulin A (S100A8) in lesional and perilesional skin in patients suffering from hidradenitis suppurativa

2020 ◽  
Vol 34 (8) ◽  
Author(s):  
A. Batycka‐Baran ◽  
M. Koziol‐Galczynska ◽  
A. Bieniek ◽  
R. Wolf ◽  
Ł. Łaczmański ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Calgranulin A ◽  
Perilesional Skin

Alterations in leucocyte subsets and histomorphology in normal-appearing perilesional skin and early and chronic hidradenitis suppurativa lesions

2011 ◽  
Vol 166 (1) ◽  
pp. 98-106 ◽  
Author(s):  
H.H. van der Zee ◽  
L. de Ruiter ◽  
J. Boer ◽  
D.G. van den Broecke ◽  
J.C. den Hollander ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Perilesional Skin

Real-Time Confocal Imaging for Hidradenitis Suppurativa: Description of Morphological Aspects and Focus on the Role of Follicular Ostia

Dermatology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Simone Cappilli ◽  
Giulia Giovanardi ◽  
Alessandro Di Stefani ◽  
Caterina Longo ◽  
Francesca Perino ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Amorphous Material ◽  
Confocal Imaging ◽  
Control Group ◽  
Healthy Skin ◽  
Definition Of ◽  
Microscopic Morphology ◽  
Perilesional Skin

<b><i>Background:</i></b> Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease involving the follicular unit. Growing evidence suggests a crucial role of hyperkeratosis, infundibular plugging and perifolliculitis in its pathogenesis. <b><i>Objectives:</i></b> To characterize the microscopic morphology of open comedos using in vivo reflectance confocal microscopy (RCM) and define alterations occurring in HS normal-appearing perilesional skin compared to healthy skin of a control group, discussing therefore microscopic differences. <b><i>Materials and Methods:</i></b> Twenty patients (11 males, 9 females; aged 19–51 years) affected by HS were recruited. RCM was performed on open comedos of axillary/inguinal regions and on normal-appearing skin areas distant at least 1.5 cm from HS lesions. Ten healthy individuals (6 males, 4 females) were included as control group. <b><i>Results:</i></b> RCM aspects of 78 open comedos were explored, observing circular/ovoidal structures disclosing a hyperrefractive amorphous material (72/78, 92.3%) within the infundibular cavity surrounded with a bright (51/78, 65.4%) and regular (52/78, 66.2%) border. Follicular ostia of HS perilesional skin (<i>n</i> = 541) compared to follicular ostia of a control group (<i>n</i> = 321) were characterized by a larger infundibular diameter (183.4 vs. 85.8 µm) and diverged in terms of material collected inside infundibula (44.5 vs. 21%) and keratinization of the border (47.6 vs. 25.5%). <b><i>Conclusion:</i></b> In vivo characterization of open comedos and the recognition of microscopic subclinical alterations of HS normal-appearing skin, compared to healthy skin, could add further insights into the definition of biological events leading to HS manifestations, including the dysregulated process of keratinization.

Surgical treatment of extensive perianal hidradenitis

2020 ◽  
Vol 99 (9) ◽  
Keyword(s):  
Surgical Treatment ◽  
Hidradenitis Suppurativa ◽  
Soft Tissues ◽  
Case Reports ◽  
Radical Excision ◽  
Skin Flaps ◽  
Perianal Area ◽  
Apocrine Glands ◽  
Patient Preparation ◽  
Two Stages

Introduction: Perianal hidradenitis suppurativa is a chronic recurrent inflammatory, suppurative, and fistulising disease of apocrine glands, adjacent anal canal and soft tissues. Perianal area is the second most common affected area after axilla. There are three grades of the disease. Hidradenitis suppurativa represents a chronic, recurrent, deep-seated folliculitis resulting in abscesses, followed by the formation of sinus tracts and subsequent scarring. Perianal hidradenitis suppurativa is the last and the most serious grade of the disease and a specific access is needed for patient preparation and surgical treatment alone. The currently preferred method of treatment for patients with extensive perianal hidradentitis is excision and closure with combination of skin flaps, primary suture and skin graft in one or two stages. Case reports: There are three case reports of perianal hidradenitis suppurativa in this article. The local and overall initial treatment of patients followed by a radical excision and closure with a rotation skin flaps and skin grafts is described. The final results were satisfactory, with no recurrence or serious complication.

Characterization of comorbid conditions burdening hidradenitis suppurativa: a multicentric observational study

2020 ◽  
Vol 155 (3) ◽  
Author(s):  
Andrea Chiricozzi ◽  
Giulia Giovanardi ◽  
Dante R. Caposiena Caro ◽  
Michela Iannone ◽  
Clara De Simone ◽  
...  
Keyword(s):  
Observational Study ◽  
Hidradenitis Suppurativa ◽  
Comorbid Conditions

New insights into mechanism of Notch signaling in hidradenitis suppurativa

2020 ◽  
Vol 155 (4) ◽  
Author(s):  
Emanuele Scala ◽  
Anna Balato ◽  
Claudio Marasca ◽  
Roberta Di Caprio ◽  
Annunziata Raimondo ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Hidradenitis Suppurativa
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