Histopathology and reflectance confocal microscopy features of photodamaged skin and actinic keratosis

2016 ◽  
Vol 30 (11) ◽  
pp. 1901-1911 ◽  
Author(s):  
J.M. Tan ◽  
D. Lambie ◽  
S. Sinnya ◽  
A. Sahebian ◽  
H.P. Soyer ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Actinic Keratosis ◽  
Reflectance Confocal Microscopy ◽  
Photodamaged Skin

scholarly journals Dermoscopy and Reflectance Confocal Microscopy for Monitoring the Treatment of Actinic Keratosis with Ingenol Mebutate Gel: Report of Two Cases

2016 ◽  
Vol 6 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Caterina Longo ◽  
Stefania Borsari ◽  
Elisa Benati ◽  
Elvira Moscarella ◽  
Roberto Alfano ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Actinic Keratosis ◽  
Reflectance Confocal Microscopy ◽  
Ingenol Mebutate

scholarly journals Assessment of the Effect of 3% Diclofenac Sodium on Photodamaged Skin by Means of Reflectance Confocal Microscopy

2018 ◽  
Vol 98 (10) ◽  
pp. 963-969 ◽  
Author(s):  
G Segurado-Miravalles ◽  
N Jiménez-Gómez ◽  
O Moreno-Arrones ◽  
I Alarcón-Salazar ◽  
A Alegre-Sánchez ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Diclofenac Sodium ◽  
Reflectance Confocal Microscopy ◽  
Photodamaged Skin

scholarly journals In Vivo Reflectance Confocal Microscopy as a Response Monitoring Tool for Actinic Keratoses Undergoing Cryotherapy and Photodynamic Therapy

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5488
Author(s):  
Clara Curiel-Lewandrowski ◽  
Caitlyn N. Myrdal ◽  
Kathylynn Saboda ◽  
Chengcheng Hu ◽  
Edith Arzberger ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Cellular Level ◽  
Reflectance Confocal Microscopy ◽  
Response Monitoring ◽  
Significant Treatment ◽  
Biological Responses ◽  
Photodamaged Skin ◽  
Most Significant Change ◽  
Over Time

Reflectance confocal microscopy (RCM) presents a non-invasive method to image actinic keratosis (AK) at a cellular level. However, RCM criteria for AK response monitoring vary across studies and a universal, standardized approach is lacking. We aimed to identify reliable AK response criteria and to compare the clinical and RCM evaluation of responses across AK severity grades. Twenty patients were included and randomized to receive either cryotherapy (n = 10) or PDT (n = 10). Clinical assessment and RCM evaluation of 12 criteria were performed in AK lesions and photodamaged skin at baseline, 3 and 6 months. We identified the RCM criteria that reliably characterize AK at baseline and display significant reduction following treatment. Those with the highest baseline odds ratio (OR), good interobserver agreement, and most significant change over time were atypical honeycomb pattern (OR: 12.7, CI: 5.7–28.1), hyperkeratosis (OR: 13.6, CI: 5.3–34.9), stratum corneum disruption (OR: 7.8, CI: 3.5–17.3), and disarranged epidermal pattern (OR: 6.5, CI: 2.9–14.8). Clinical evaluation demonstrated a significant treatment response without relapse. However, in grade 2 AK, 10/12 RCM parameters increased from 3 to 6 months, which suggested early subclinical recurrence detection by RCM. Incorporating standardized RCM protocols for the assessment of AK may enable a more meaningful comparison across clinical trials, while allowing for the early detection of relapses and evaluation of biological responses to therapy over time.

Evaluation of diagnostic criteria of actinic keratosis through reflectance confocal microscopy

2020 ◽  
Vol 26 (6) ◽  
pp. 883-890
Author(s):  
Amanda Mota ◽  
Juan Manuel Piñeiro‐Maceira ◽  
Carlos Barcaui
Keyword(s):  
Confocal Microscopy ◽  
Diagnostic Criteria ◽  
Actinic Keratosis ◽  
Reflectance Confocal Microscopy
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