scholarly journals Comparisons of efficacy and safety in insulin glargine and lixisenatide (iGlarLixi) plus glulisine combination therapy with multiple daily injection therapy in Japanese patients with type 2 diabetes

2021 ◽  
Author(s):  
Yuji Kawaguchi ◽  
Shoko Miyamoto ◽  
Yuriko Hajika ◽  
Narumi Ashida ◽  
Koji Masumoto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Combination Therapy ◽  
Insulin Glargine ◽  
Japanese Patients ◽  
Injection Therapy ◽  
Daily Injection ◽  
Efficacy And Safety ◽  
Multiple Daily Injection

scholarly journals Liraglutide in Adults with Type 2 Diabetes: Global Perspective on Safety, Efficacy and Patient Preference

2011 ◽  
Vol 4 ◽  
pp. CMED.S5976 ◽  
Author(s):  
Daisuke Yabe ◽  
Yutaka Seino
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trials ◽  
Glucagon Secretion ◽  
Japanese Patients ◽  
Global Perspective ◽  
Daily Injection ◽  
Efficacy And Safety ◽  
New Class ◽  
Glucagon Like Peptide 1

Incretin-based therapies have been gaining much attention recently as a new class of therapeutics for type 2 diabetes worldwide. Among them, glucagon-like peptide-1 receptor agonist liraglutide has been rapidly increasing its global usage. Once daily injection of liraglutide significantly ameliorates glycemic control in patients with type 2 diabetes by enhancing insulin secretion and suppressing glucagon secretion glucose-dependently. Liraglutide delays gastric emptying and suppresses food intakes, both of which contribute to glucose lowering and weight reduction. Efficacy and safety of liraglutide in management of type 2 diabetes have been well documented in several key clinical trials such as series of phase 3 Liraglutide Effect and Action in Diabetes (LEAD) trials, and the liraglutide-versus-sitagliptin trial. Recent two trials dealing with monotherapy and sulfonylurea combination therapy on Japanese patients with type 2 diabetes furthermore indicate liraglutide's effectiveness in non-obese diabetes. In this review, we summarize results from such clinical trials, and discuss efficacy and safety of liraglutide in management of type 2 diabetes in various countries, along with a pitfall of liraglutide usage in real clinical setting.

scholarly journals Efficacy and safety of switching to insulin glargine 300 U/mL from 100 U/mL in Japanese patients with type 2 diabetes: A 12-month retrospective analysis

Heliyon ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e01257
Author(s):  
Kazutoshi Sugiyama ◽  
Shu Meguro ◽  
Yoshifumi Saisho ◽  
Junichiro Irie ◽  
Masami Tanaka ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Glargine ◽  
Retrospective Analysis ◽  
Japanese Patients ◽  
Efficacy And Safety
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