scholarly journals Association of type 2 diabetes susceptibility loci with peripheral nerve function in a Chinese population with diabetes

2016 ◽  
Vol 8 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Jingyi Lu ◽  
Yi Luo ◽  
Jie Wang ◽  
Cheng Hu ◽  
Rong Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Chinese Population ◽  
Nerve Function ◽  
Susceptibility Loci ◽  
Diabetes Susceptibility ◽  
Peripheral Nerve Function

Serum albumin is associated with peripheral nerve function in patients with type 2 diabetes

Endocrine ◽  
2015 ◽  
Vol 50 (2) ◽  
pp. 397-404 ◽  
Author(s):  
Lu Li ◽  
Bo Liu ◽  
Jingyi Lu ◽  
Lan Jiang ◽  
Yinan Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Serum Albumin ◽  
Nerve Function ◽  
Peripheral Nerve Function

Relationship Between AST/ALT Ratio and Peripheral Nerve Function in Type 2 Diabetes Mellitus

Nano LIFE ◽  
2020 ◽  
Vol 10 (01n02) ◽  
pp. 2040004 ◽  
Author(s):  
Yinan Zhang ◽  
Lizhi Zhang ◽  
Fengwen Li ◽  
Bo Liu ◽  
Chen Chu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Nerve ◽  
Liver Enzymes ◽  
Nerve Function ◽  
Peripheral Nerve Function ◽  
Glutamyl Transferase ◽  
Group 1

Background: The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio is suggested to be related to the increased risks of many metabolic diseases, whereas its association with neurological function in type 2 diabetes mellitus (T2DM) has not been understood. In this study, we aim to investigate the relationships between serum liver enzymes (ALT, AST, the AST/ALT ratio, gamma-glutamyl transferase (GGT)) and peripheral nerve function in patients with T2DM. Methods: In Group 1, we analyzed the associations between parameters of nerve function and liver enzymes in 460 T2DM patients from rural area of Shanghai. Besides, the same methods were applied to another group of 828 T2DM subjects from urban area of Shanghai. Results: In Group 1, the AST/ALT ratio was significantly higher in patients with abnormal nerve conduction [Formula: see text]. The peripheral nerve function significantly declined with increasing tertiles of AST/ALT ratio ([Formula: see text]). After adjustment for all potential confounders, the ratio of AST/ALT was still negatively correlated with the composite Z-scores of conduction velocity (CV). In Group 2, similar significant associations were found between the AST/ALT ratio and peripheral nerve function after adjustment for covariates. Conclusions: In two independent T2DM populations, the AST/ALT ratio was independently and consistently related to peripheral nerve function. The AST/ALT ratio might be helpful to highlight T2DM patients at high risk for diabetic peripheral neuropathy.

scholarly journals Influence of Risk Factors and Diabetic Complications on Peripheral Nerve Function in Type 2 Diabetes Mellitus

2015 ◽  
Vol 61 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Bălașa Rodica ◽  
Z. Bajko ◽  
Smaranda Maier ◽  
S. Voidăzan ◽  
Anca Moțățăianu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control ◽  
Peripheral Nerve ◽  
Sural Nerve ◽  
Sensory Nerve ◽  
Nerve Function ◽  
Peripheral Nerve Function

Abstract Objective: The aim of this study was to evaluate the impact of age, diabetes duration, glycaemic control, existence of cardiac autonomic neuropathy (CAN), retinopathy and of macroangiopathy on the peripheral nerve function in patients with type 2 diabetes. Methods: One hundred forty-nine type 2 diabetes mellitus patients were assessed with peripheral motor and sensory nerve conduction tests and cardiovascular reflex tests, as well as being evaluated for retinopathy, common carotid artery intimal-media-thickness (IMT) and anklebrachial index (ABI). Results: The duration of diabetes has the strongest effect in the reduction of the amplitude of motor response in the peroneal nerve and of the sensory amplitude in the sural nerve. The strongest correlations were found between glycaemic control and decreasing motor amplitude in the median nerve and sensory amplitude in the sural nerve, respectively. The motor and sensory nerve action potential amplitudes were significantly affected in the group of patients with CAN. According to multivariate logistic regression analysis, duration of diabetes and presence of CAN were the most important factors that influenced the motor and sensory nerve function. Conclusion: The presence of CAN together with diabetes duration and poor glycaemic control were associated with impaired peripheral nerve function, while macroangiopathy does not seem to be associated with the impairment of these electrophysiological parameters.

scholarly journals Aldose Reductase Gene Polymorphisms and Peripheral Nerve Function in Patients With Type 2 Diabetes

Diabetes Care ◽  
2004 ◽  
Vol 27 (8) ◽  
pp. 2021-2026 ◽  
Author(s):  
K. Sivenius ◽  
J. Pihlajamaki ◽  
J. Partanen ◽  
L. Niskanen ◽  
M. Laakso ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Nerve ◽  
Aldose Reductase ◽  
Gene Polymorphisms ◽  
Nerve Function ◽  
Reductase Gene ◽  
Peripheral Nerve Function
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