Soluble CD163 levels are elevated in cerebrospinal fluid and serum in people with Type 2 diabetes mellitus and are associated with impaired peripheral nerve function

2014 ◽  
Vol 32 (1) ◽  
pp. 54-61 ◽  
Author(s):  
M. Kallestrup ◽  
H. J. Møller ◽  
H. Tankisi ◽  
H. Andersen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cerebrospinal Fluid ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Nerve ◽  
Nerve Function ◽  
Soluble Cd163 ◽  
Peripheral Nerve Function

Relationship Between AST/ALT Ratio and Peripheral Nerve Function in Type 2 Diabetes Mellitus

Nano LIFE ◽  
2020 ◽  
Vol 10 (01n02) ◽  
pp. 2040004 ◽  
Author(s):  
Yinan Zhang ◽  
Lizhi Zhang ◽  
Fengwen Li ◽  
Bo Liu ◽  
Chen Chu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Nerve ◽  
Liver Enzymes ◽  
Nerve Function ◽  
Peripheral Nerve Function ◽  
Glutamyl Transferase ◽  
Group 1

Background: The aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio is suggested to be related to the increased risks of many metabolic diseases, whereas its association with neurological function in type 2 diabetes mellitus (T2DM) has not been understood. In this study, we aim to investigate the relationships between serum liver enzymes (ALT, AST, the AST/ALT ratio, gamma-glutamyl transferase (GGT)) and peripheral nerve function in patients with T2DM. Methods: In Group 1, we analyzed the associations between parameters of nerve function and liver enzymes in 460 T2DM patients from rural area of Shanghai. Besides, the same methods were applied to another group of 828 T2DM subjects from urban area of Shanghai. Results: In Group 1, the AST/ALT ratio was significantly higher in patients with abnormal nerve conduction [Formula: see text]. The peripheral nerve function significantly declined with increasing tertiles of AST/ALT ratio ([Formula: see text]). After adjustment for all potential confounders, the ratio of AST/ALT was still negatively correlated with the composite Z-scores of conduction velocity (CV). In Group 2, similar significant associations were found between the AST/ALT ratio and peripheral nerve function after adjustment for covariates. Conclusions: In two independent T2DM populations, the AST/ALT ratio was independently and consistently related to peripheral nerve function. The AST/ALT ratio might be helpful to highlight T2DM patients at high risk for diabetic peripheral neuropathy.

scholarly journals Influence of Risk Factors and Diabetic Complications on Peripheral Nerve Function in Type 2 Diabetes Mellitus

2015 ◽  
Vol 61 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Bălașa Rodica ◽  
Z. Bajko ◽  
Smaranda Maier ◽  
S. Voidăzan ◽  
Anca Moțățăianu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control ◽  
Peripheral Nerve ◽  
Sural Nerve ◽  
Sensory Nerve ◽  
Nerve Function ◽  
Peripheral Nerve Function

Abstract Objective: The aim of this study was to evaluate the impact of age, diabetes duration, glycaemic control, existence of cardiac autonomic neuropathy (CAN), retinopathy and of macroangiopathy on the peripheral nerve function in patients with type 2 diabetes. Methods: One hundred forty-nine type 2 diabetes mellitus patients were assessed with peripheral motor and sensory nerve conduction tests and cardiovascular reflex tests, as well as being evaluated for retinopathy, common carotid artery intimal-media-thickness (IMT) and anklebrachial index (ABI). Results: The duration of diabetes has the strongest effect in the reduction of the amplitude of motor response in the peroneal nerve and of the sensory amplitude in the sural nerve. The strongest correlations were found between glycaemic control and decreasing motor amplitude in the median nerve and sensory amplitude in the sural nerve, respectively. The motor and sensory nerve action potential amplitudes were significantly affected in the group of patients with CAN. According to multivariate logistic regression analysis, duration of diabetes and presence of CAN were the most important factors that influenced the motor and sensory nerve function. Conclusion: The presence of CAN together with diabetes duration and poor glycaemic control were associated with impaired peripheral nerve function, while macroangiopathy does not seem to be associated with the impairment of these electrophysiological parameters.

scholarly journals Visceral obesity is associated with increased soluble CD163 concentration in men with type 2 diabetes mellitus

2015 ◽  
Vol 4 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Lars Peter Sørensen ◽  
Tina Parkner ◽  
Esben Søndergaard ◽  
Bo Martin Bibby ◽  
Holger Jon Møller ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Body Fat ◽  
Fat Distribution ◽  
Normal Weight ◽  
Healthy Men ◽  
Soluble Cd163

Monocyte/macrophage-specific soluble CD163 (sCD163) concentration is associated with insulin resistance and increases with deteriorating glycemic control independently of BMI. This led to the proposal of the hypothesis that obesity-associated white adipose tissue inflammation varies between individuals. The objective was to examine the effect of male overweight/obesity and type 2 diabetes mellitus (T2DM) on associations between adiposity parameters and sCD163. A total of 23 overweight/obese non-diabetic men, 16 overweight/obese men with T2DM, and a control group of 20 normal-weight healthy men were included. Body composition and regional body fat distribution were determined by whole-body dual X-ray absorptiometry scan and abdominal computed tomography (CT) scan. Serum sCD163 concentrations were determined by ELISA. Associations between adiposity parameters and sCD163 were investigated using multiple linear regression analysis. In the normal-weight healthy men, there was no significant association between adiposity parameters and sCD163, whereas in the overweight/obese non-diabetic men, measures of general and regional adiposity were positively associated with sCD163. In the overweight/obese men with T2DM, only visceral adipose tissue (VAT) and the ratio of VAT to abdominal subcutaneous adipose tissue (SAT), a measure of relative body fat distribution between VAT and SAT depots, were positively associated with sCD163. In a multivariate analysis, including VAT, upper-body SAT, and lower-body fat, adjusted for BMI and age, VAT remained a significant predictor of sCD163 in the overweight/obese T2DM men, but not in the overweight/obese non-diabetic men. Our results indicate that VAT inflammation is exaggerated in men with T2DM, and that propensity to store excess body fat viscerally is particularly detrimental in men with T2DM.

scholarly journals Relationship of serum ionized calcium and magnesium concentration with parasympathetic nerve Function in type 2 diabetes mellitus

2016 ◽  
Vol 11 (2) ◽  
pp. 70-73
Author(s):  
Md Khairul Alam ◽  
Noorzahan Begum ◽  
Shelina Begum
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Ionized Calcium ◽  
Magnesium Concentration ◽  
Nerve Function ◽  
Parasympathetic Nerve ◽  
Serum Ionized Calcium ◽  
Calcium And Magnesium

Background: Changes in serum Ca2+ and Mg2+ level may have some relationship to the occurrence of autonomic neuropathy in diabetes.Objective: To observe relationship between parasympathetic nerve function and serum ionized calcium & magnesium in type 2 diabetes mellitus (T2DM).Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka on 47 T2DM patients aged 40-68 years of both sexes. Twenty five patients were recently diagnosed diabetics (RDM) and 22 were long term diabetics (LDM) with 10-20 years duration of diabetes. Parasympathetic nerve functions of all patients were assessed by three simple non-invasive cardiovascular reflex tests. Ionized serum calcium and magnesium were measured by ion sensitive electrode method using NOVA electrode. Data were analyzed by unpaired‘t’test and Pearson’s correlation co-efficient test.Results: Serum ionized calcium and magnesium levels were significantly higher in RDM (P<0.001) and LDM (P<0.001) compared to healthy control. On correlation analysis, significant negative correlation of parasympathetic nerve function with Mg2+was found in both RDM and LDM patients.Conclusion: The result of this study concluded that higher calcium and magnesium ion may be associated with type 2 diabetes and parasympathetic nerve function of diabetic patients may have inverse relationship to serum Mg2+.Bangladesh Soc Physiol. 2016, December; 11(2): 70-73

scholarly journals Correction to: Soluble CD163, adiponectin, C-reactive protein and progression of dysglycaemia in individuals at high risk of type 2 diabetes mellitus: the ADDITION-PRO cohort

Diabetologia ◽  
2017 ◽  
Vol 61 (2) ◽  
pp. 498-503
Author(s):  
Pia Deichgræber ◽  
Daniel R. Witte ◽  
Holger J. Møller ◽  
Mette V. Skriver ◽  
Bjørn Richelsen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
High Risk ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Soluble Cd163

scholarly journals Impairment of the glymphatic system after diabetes

2016 ◽  
Vol 37 (4) ◽  
pp. 1326-1337 ◽  
Author(s):  
Quan Jiang ◽  
Li Zhang ◽  
Guangliang Ding ◽  
Esmaeil Davoodi-Bojd ◽  
Qingjiang Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cerebrospinal Fluid ◽  
Type 2 Diabetes Mellitus ◽  
Cognitive Deficits ◽  
Interstitial Fluid ◽  
Brain Mri ◽  
Fluid Exchange ◽  
Glymphatic System

The glymphatic system has recently been shown to clear brain extracellular solutes and abnormalities in glymphatic clearance system may contribute to both initiation and progression of neurological diseases. Despite that diabetes is known as a risk factor for vascular diseases, little is known how diabetes affects the glymphatic system. The current study is the first investigation of the effect of diabetes on the glymphatic system and the link between alteration of glymphatic clearance and cognitive impairment in Type-2 diabetes mellitus rats. MRI analysis revealed that clearance of cerebrospinal fluid contrast agent Gd-DTPA from the interstitial space was slowed by a factor of three in the hippocampus of Type-2 diabetes mellitus rats compared to the non-DM rats and confirmed by florescence imaging analysis. Cognitive deficits detected by behavioral tests were highly and inversely correlated to the retention of Gd-DTPA contrast and fluorescent tracer in the hippocampus of Type-2 diabetes mellitus rats. Type-2 diabetes mellitus suppresses clearance of interstitial fluid in the hippocampus and hypothalamus, suggesting that an impairment of the glymphatic system contributes to Type-2 diabetes mellitus-induced cognitive deficits. Whole brain MRI provides a sensitive, non-invasive tool to quantitatively evaluate cerebrospinal fluid and interstitial fluid exchange in Type-2 diabetes mellitus and possibly in other neurological disorders, with potential clinical application.

scholarly journals Effect of Deep Relaxation Technique on Cardiac Autonomic Dysfunction in Type 2 Diabetes Mellitus

2018 ◽  
Vol 13 (1) ◽  
pp. 22-28 ◽  
Author(s):  
Farhana Rahman ◽  
Sultana Ferdousi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Type 2 Diabetes Mellitus ◽  
Autonomic Dysfunction ◽  
Time Domain ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
Autonomic Nerve Function

Background: Type 2 Diabetes Mellitus (T2DM) may be associated with autonomic dysfunction. Performance of deep relaxation technique (DRT) may cause upturn of this deranged nerve function.Objective: To evaluate the impact of DRT on cardiac autonomic nerve function by analysis of time domain series of Heart Rate Variability (HRV) in T2DM patients.Methods: This prospective study was carried out on 30 female T2DM patients aged 50-55 years with duration of diabetes of 5-10 years enrolled from the Out Patient Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka. They performed DRT (20 minutes twice daily) for 3 months. Thirty apparently healthy female with similar age who did not perform DRT or any other form of exercise, were included as control. To assess the cardiac autonomic nerve function, time domain measures of HRV of all subjects were recorded by a data acquisition device Power Lab (Australia). HRV data of all subjects were collected at baseline (pre) and also after 3 months(Post). For statistical analysis, paired and independent sample t-test were used.Results: The pre-intervention values of resting HR was significantly higher (p<0.001) and mean R-R interval, SDRR, CVRR, SDSD, RMSSD and pRR50% were significantly lower (p<0.001) in all diabetic patients compared to control. After 3 months of DRT, there was significant decrement in resting mean heart rate (p<0.01) and significant increment in mean R-R interval, SDRR, CVRR, SDSD, RMSSD and pRR50% (p<0.001) compared to their pre-intervention values.Conclusion: Cardiac autonomic nerve dysfunction may occur in T2DM and 3 months regular practice of DRT mayy significantly improv cardiac autonomic nerve function with parasympathetic dominance.J Bangladesh Soc Physiol. 2018, June; 13(1): 22-28

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