scholarly journals A questionnaire‐based crossover study on the association of microbiological testing with prescription of systemic antibiotics following initial periodontal therapy

2021 ◽  
Vol 48 (5) ◽  
pp. 618-626
Author(s):  
Camille Vrijghem ◽  
Jan Cosyn ◽  
Jasper Fransen ◽  
Véronique Christiaens
Keyword(s):  
Crossover Study ◽  
Periodontal Therapy ◽  
Microbiological Testing ◽  
Systemic Antibiotics

scholarly journals Antibiotic Use in Periodontal Therapy among French Dentists and Factors Which Influence Prescribing Practices

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 303
Author(s):  
Kevimy Agossa ◽  
Kadiatou Sy ◽  
Théo Mainville ◽  
Marjolaine Gosset ◽  
Sylvie Jeanne ◽  
...  
Keyword(s):  
Antibiotic Use ◽  
Aggressive Periodontitis ◽  
Periodontal Therapy ◽  
Research Network ◽  
Prescribing Practices ◽  
French Society ◽  
Private Practitioners ◽  
First Line Therapy ◽  
Practice Based Research ◽  
Systemic Antibiotics

The aim of the present survey is to investigate the use of antibiotics during periodontal therapy among French dentists with a focus on exploring potential differences between various groups of practitioners. A self-administered questionnaire was distributed to different groups of practitioners including members of (i) the French Society of Periodontology and Implantology; (ii) the College of University Teachers in Periodontology and, (iii) private practitioners participating in the French general dental practice-based research network. 272 questionnaires were included in the analysis. Prescription patterns were globally in line with the current recommendations. Systemic antibiotics are most frequently used as a first-line therapy in necrotizing periodontitis (92%) and aggressive periodontitis (53.3% to 66.1%). However, malpractice still exists, including in the management of periodontal abscesses. Antibiotics are prescribed (i) less frequently for periodontal abscesses and (ii) more frequently for generalized aggressive periodontitis by members of the periodontal society and University college (p < 0.05). Amoxicillin (59.9%) and the amoxicillin + metronidazole (59.6%) combination were the most frequently prescribed molecules. Providing a high number of periodontal treatments per week, being more recently graduated, having a post-graduate certificate in periodontology and holding or having held an academic position/hospital practice were all factors associated with a better knowledge of and/or more adequate antibiotic use.

scholarly journals Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis

2018 ◽  
Vol 68 (4) ◽  
pp. 207-220 ◽  
Author(s):  
Maria Luisa S. Souto ◽  
Emanuel S. Rovai ◽  
Juliana A. Ganhito ◽  
Marinella Holzhausen ◽  
Leandro Chambrone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Periodontal Therapy ◽  
Nonsurgical Periodontal Therapy ◽  
Systemic Antibiotics

Administration of systemic antibiotics during non-surgical periodontal therapy—a consensus report

2018 ◽  
Vol 23 (7) ◽  
pp. 3073-3085 ◽  
Author(s):  
B. Pretzl ◽  
S. Sälzer ◽  
B Ehmke ◽  
U. Schlagenhauf ◽  
B. Dannewitz ◽  
...  
Keyword(s):  
Periodontal Therapy ◽  
Systemic Antibiotics ◽  
Consensus Report

scholarly journals Periodontal therapy increases neutrophil extracellular trap degradation

2019 ◽  
Vol 26 (5) ◽  
pp. 331-340 ◽  
Author(s):  
Carolyn GJ Moonen ◽  
Kirsten GD Buurma ◽  
Mouri RJ Faruque ◽  
Maria G Balta ◽  
Erol Liefferink ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Neutrophil Extracellular Traps ◽  
Periodontal Therapy ◽  
Neutrophil Extracellular Trap ◽  
Polymorphonuclear Leucocytes ◽  
Background Characteristics ◽  
Extracellular Traps ◽  
Inflammatory Status ◽  
Before And After ◽  
Systemic Antibiotics

In periodontitis, polymorphonuclear leucocytes (PMNs) are activated. They entrap and eliminate pathogens by releasing neutrophil extracellular traps (NETs). Abnormal NET degradation is part of a pro-inflammatory status, affecting co-morbidities such as cardiovascular disease. We aimed to investigate the ex vivo NET degradation capacity of plasma from periodontitis patients compared to controls (part 1) and to quantify NET degradation before and after periodontal therapy (part 2). Fresh NETs were obtained by stimulating blood-derived PMNs with phorbol 12-myristate 13-acetate. Plasma samples from untreated periodontitis patients and controls were incubated for 3 h onto freshly generated NETs (part 1). Similarly, for part 2, NET degradation was studied for 91 patients before and 3, 6 and 12 mo after non-surgical periodontal therapy with and without adjunctive systemic antibiotics. Finally, NET degradation was fluorospectrometrically quantified. NET degradation levels did not differ between periodontitis patients and controls, irrespective of subject-related background characteristics. NET degradation significantly increased from 65.6 ± 1.7% before periodontal treatment to 75.7 ± 1.2% at 3 mo post periodontal therapy, and this improvement was maintained at 6 and 12 mo, irrespective of systemic usage of antibiotics. Improved NET degradation after periodontitis treatment is another systemic biomarker reflecting a decreased pro-inflammatory status, which also contributes to an improved cardiovascular condition.

scholarly journals Terapi periodontal non-bedah Non-surgical periodontal therapy

2011 ◽  
Vol 10 (1) ◽  
pp. 36
Author(s):  
Liana Zulfa ◽  
Dewi Nurul Mustaqimah
Keyword(s):  
Disease Progression ◽  
Surgical Therapy ◽  
Clinical Data ◽  
Host Response ◽  
Bacterial Pathogen ◽  
Periodontal Therapy ◽  
Tooth Surface ◽  
Response Modulation ◽  
Microbial Etiology ◽  
Systemic Antibiotics

Non surgical periodontal therapy is the first step in periodontal therapy procedure. Elimination of biofilm andmineral deposit from tooth surface is a basic of periodontal therapy. Clinical data showed that the success of longterm periodontal therapy depends on the result of first step compare to spesific surgical therapy. Methods used innon surgical therapy are mechanical instrumentation, ultrasonic debridement, supragingival and subgingivalirigation, localized drugs, systemic antibiotics, and host response modulation. The successful of periodontal therapydepends on the management of negative environment and reduction of bacterial pathogen through a combination ofbetter environment which is less anaerobic for good microorganism to live. The aim of non surgical therapy is toreduce microbial etiology and factors involved in the progression of gingiva and periodontal. The end result is tostop the disease progression and to gain healthy gingiva and tissue condition.

scholarly journals Non-Surgical Periodontal Therapy with Adjunctive Amoxicillin/Metronidazole or Metronidazole When No Aggregatibacter actinomycetemcomitans Is Detected—A Randomized Clinical Trial

Antibiotics ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 686
Author(s):  
Holger F. R. Jentsch ◽  
Martin Dietrich ◽  
Sigrun Eick
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Gingival Crevicular Fluid ◽  
Aggregatibacter Actinomycetemcomitans ◽  
Periodontal Therapy ◽  
Clinical Attachment Level ◽  
Probing Depth ◽  
Crevicular Fluid ◽  
Systemic Antibiotics ◽  
Attachment Level

Background: The aim was to compare two different systemic antibiotics regimens adjunctive to non-surgical periodontal therapy when Aggregatibacter actinomycetemcomitans was not detected in the subgingival biofilm. Methods: A total of 58 patients with periodontitis and with no A. actinomycetemcomitans in the subgingival biofilm were treated with full-mouth subgingival instrumentation and either metronidazole (MET; n = 29) or amoxicillin/metronidazole (AMX/MET; n = 29). Probing depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP) were recorded at baseline, as well as after three and six months. Subgingival biofilm and gingival crevicular fluid were collected and analyzed for major periodontopathogens and biomarkers. Results: PD, CAL and BOP improved at 3 and 6 months (each p < 0.001 vs. baseline) with no difference between the groups. Sites with initial PD ≥ 6 mm also improved in both groups after 3 and 6 months (p < 0.001) with a higher reduction of PD in the AMX/MET group (p < 0.05). T. forsythia was lower in the AMX/MET group after 3 months (p < 0.05). MMP-8 and IL-1β were without significant changes and differences between the groups. Conclusion: When A. actinomycetemcomitans was not detected in the subgingival biofilm, the adjunctive systemic use of amoxicillin/metronidazole results in better clinical and microbiological outcomes of non-surgical periodontal therapy when the application of systemic antibiotics is scheduled.

scholarly journals Significant of Antibiotic prophylaxis for diabetic patients with periodontal disease, 1 hour before phase 1 periodontal therapy

2020 ◽  
Vol 10 (1) ◽  
pp. 28-30
Author(s):  
Puja Shrestha ◽  
Md Ashif Iqbal ◽  
Orin Chowdhury Bristy ◽  
Nimesh Sherestha
Keyword(s):  
Periodontal Disease ◽  
Antibiotic Prophylaxis ◽  
Periodontal Diseases ◽  
Phase 1 ◽  
Periodontal Therapy ◽  
Diabetic Patients ◽  
Glucose Levels ◽  
Management Protocol ◽  
Patients With Diabetes ◽  
Systemic Antibiotics

People with diabetes are more likely to have periodontal diseases than people without diabetes. Periodontal disease is often considered a complication of diabetes. On the other hand, severe periodontal disease can increase blood glucose levels. Special care and management protocol need to be addressed to patients with diabetes during periodontal therapy. Systemic antibiotics in conjunction with scaling and root planning can offer an additional benefit over SRP alone in the treatment of periodontitis. This review aims to evaluate the significance of antibiotic prophylaxis for diabetic patients with the periodontal disease before 1 hour/ 1-2 days of phase 1 periodontal therapy. The goal of antibiotic prophylaxis is to prevent the onset of injections through the entranceway provided by the therapeutic action. But currently, no established guidelines are in place for antibiotic prophylaxis before periodontal therapy. Update Dent. Coll. j: 2020; 10 (1): 28-30

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