scholarly journals Efficacy of systemic antibiotics in nonsurgical periodontal therapy for diabetic subjects: a systematic review and meta-analysis

2018 ◽  
Vol 68 (4) ◽  
pp. 207-220 ◽  
Author(s):  
Maria Luisa S. Souto ◽  
Emanuel S. Rovai ◽  
Juliana A. Ganhito ◽  
Marinella Holzhausen ◽  
Leandro Chambrone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Periodontal Therapy ◽  
Nonsurgical Periodontal Therapy ◽  
Systemic Antibiotics

Impact of Smoking Cessation on Periodontitis: A Systematic Review and Meta-analysis of Prospective Longitudinal Observational and Interventional Studies

2018 ◽  
Vol 21 (12) ◽  
pp. 1600-1608 ◽  
Author(s):  
Fábio R M Leite ◽  
Gustavo G Nascimento ◽  
Stina Baake ◽  
Lisa D Pedersen ◽  
Flemming Scheutz ◽  
...  
Keyword(s):  
Systematic Review ◽  
Smoking Cessation ◽  
Tobacco Smoking ◽  
Meta Analysis ◽  
Periodontal Therapy ◽  
Periodontal Treatment ◽  
Nonsurgical Periodontal Therapy ◽  
Never Smokers ◽  
Prospective Longitudinal ◽  
The Impact

Abstract Aims This systematic review aimed to estimate the effect of tobacco smoking cessation on the risk for periodontitis compared to the risk among never-smokers and to evaluate the effect of tobacco smoking cessation on the clinical outcomes of nonsurgical periodontal treatment. Methods Electronic searches were performed in PubMed, Scopus, and Embase. Search strategy included MeSH and free terms: periodontitis, periodontal diseases, smoking, tobacco use, tobacco, tobacco products, cigarette, pipe, and cigar. Only original prospective longitudinal observational and interventional studies that investigated the association between smoking cessation and periodontitis onset or progression were included. Meta-analyses were conducted to summarize the evidence. Results A total of 2743 articles were identified in electronic searches; out of which only six were included in the meta-analysis. Pooled estimates showed that the risk of periodontitis incidence or progression among those who quit smoking was not significantly different from the risk for never-smokers (risk ratio [RR] = 0.97; 95% confidence interval [CI] = 0.87% to 1.08%). Smokers had approximately 80% higher risk of periodontitis than quitters (RR = 1.79; 95% CI = 1.36% to 2.35%) and never-smokers (RR = 1.82; 95% CI = 1.43% to 2.31%). Periodontal therapy resulted in up to 0.2 mm (95% CI = −0.32% to −0.08%) higher gain in attachment level and extra 0.32 mm (95% CI = 0.07% to 0.52%) reduction in pocket depth among quitters over nonquitters after short follow-up (12–24 months). Conclusions Few studies on the topic were identified. Smoking cessation reduced the risk for periodontitis onset and progression, and improved the outcomes of nonsurgical periodontal therapy. Implications This review provides the first quantitative evidence of the impact of smoking cessation on the risk for periodontitis onset and progression. The findings have demonstrated that the risk for periodontitis becomes comparable to that of never-smokers and that nonsurgical periodontal treatment outcomes improve after smoking cessation. Dental professionals ought to consider smoking cessation interventions as a relevant component of the periodontal therapy.

scholarly journals Effect of intra-pregnancy nonsurgical periodontal therapy on inflammatory biomarkers and adverse pregnancy outcomes: a systematic review with meta-analysis

2017 ◽  
Vol 6 (1) ◽  
Author(s):  
Helbert Eustáquio Cardoso da Silva ◽  
Cristine Miron Stefani ◽  
Nilce de Santos Melo ◽  
Adriano de Almeida de Lima ◽  
Cassiano Kuchenbecker Rösing ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Periodontal Therapy ◽  
Inflammatory Biomarkers ◽  
Nonsurgical Periodontal Therapy ◽  
Adverse Pregnancy

scholarly journals Efficacy of melatonin supplementation in the treatment of periodontitis: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yuexiang Zhen ◽  
Hui Yue ◽  
Yiting Xiao ◽  
Qin Liu ◽  
Meilin Zhao
Keyword(s):  
Systematic Review ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Periodontal Therapy ◽  
Clinical Attachment Loss ◽  
Beneficial Effects ◽  
Probing Depth ◽  
Nonsurgical Periodontal Therapy ◽  
Subgroup Analyses

Abstract Background: The aim of this systematic review and meta-analysis was to analyze the additive effects of the melatonin supplementation with nonsurgical periodontal therapy (NSPT) on periodontal status in patients affected by chronic periodontitis. Methods: In December 2020, We searched PubMed, EMBASE, Web of Science, CENTRAL databases and Google Scholar databases. Four RCTs were recruited with the same inclusion criteria. PD and CAL were the primary outcome measures. Subgroup analyses were performed according to health statuses and follow-up times, and Cochran’s Q and I-square ( I2 ) tests were used to assess heterogeneity.Results: This review included four RCTs. Four studies reported probing depth (PD) and 3 studies reported clinical attachment loss (CAL). Compared with the placebo groups, the melatonin groups showed a significant reduction in PD (weighted mean difference [WMD], -1.01; 95% confidence intervals [CI], -1.67 to -0.35; I2 = 76%) and CAL (WMD, -1.08; 95% CI: -1.36 to -0.79, I2 = 0%). Subgroup analyses revealed that the use of systemic melatonin + NSPT significantly reduced PD and CAL at the 2-, 3-, and 6-month follow-ups compared to NSPT alone, and stronger treatment effects of reducing PD were observed at shorter follow-ups than at longer follow-ups when adjunctive systemic melatonin was used.Conclusions: Melatonin supplementation in adjunct with nonsurgical periodontal therapy can moderately improve the efficacy of NSPT in reducing PD and greater CAL gain in patients with periodontitis. With the limited evidence available, it is evident that additional good quality RCTs are required to demonstrate additional beneficial effects of oral melatonin supplementation on periodontal clinical parameters after NSPT.

scholarly journals Clinical Efficacy of Repeated Applications of Local Drug Delivery and Adjunctive Agents in Nonsurgical Periodontal Therapy: A Systematic Review

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1178
Author(s):  
Oi Leng Tan ◽  
Syarida Hasnur Safii ◽  
Masfueh Razali
Keyword(s):  
Systematic Review ◽  
Drug Delivery ◽  
Clinical Efficacy ◽  
Grey Literature ◽  
Periodontal Therapy ◽  
Local Drug Delivery ◽  
Control Group ◽  
Cochrane Central Register ◽  
Nonsurgical Periodontal Therapy ◽  
Repeated Applications

The aim of this systematic review is to compare the clinical efficacy of repeated applications of local drug delivery and adjunctive agents (LDAs) in nonsurgical periodontal therapy (NSPT) compared to subgingival mechanical debridement (SMD) alone. The Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, EMBASE, Web of Science, hand-searched literature and grey literature databases were searched for randomized controlled clinical trials (RCTs) with a minimum of 6-month follow-up. The outcomes of interest were changes in probing pocket depth and clinical attachment level as well as patient-centred outcomes. Of 1094 studies identified, 16 RCTs were included in the qualitative analysis. Across 11 different adjuncts analysed, only two studies utilizing minocycline gel/ointment and antimicrobial photodynamic therapy (aPDT) with indocyanine green photosensitizer had statistically significant differences in primary outcomes when compared to their control groups. Only one study on aPDT methylene blue 0.005% had compared single versus multiple applications against its control group. A mean range of 0.27–3.82 mm PD reduction and −0.09–2.82 mm CAL gain were observed with repeated LDA application. Considerable clinical heterogeneity and methodological flaws in the included studies preclude any definitive conclusions regarding the clinical efficacy of repeated LDA applications. Future RCTs with a direct comparison between single and repeated applications should be conducted to confirm or refute the clinical advantages of repeated LDA application in the nonsurgical management of periodontitis.

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