scholarly journals Ferroptosis‐related gene NOX4 , CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma

2022 ◽  
Author(s):  
Ruoxi Xiao ◽  
Shasha Wang ◽  
Jing Guo ◽  
Shihai Liu ◽  
Aiping Ding ◽  
...  
Keyword(s):  
Related Gene ◽  
Stomach Adenocarcinoma

scholarly journals Development and validation of an immune-related gene prognostic model for stomach adenocarcinoma

2020 ◽  
Vol 40 (10) ◽  
Author(s):  
Ming Wu ◽  
Yu Xia ◽  
Yadong Wang ◽  
Fei Fan ◽  
Xian Li ◽  
...  
Keyword(s):  
Prognostic Model ◽  
Clinical Decision Making ◽  
Cox Regression ◽  
Risk Group ◽  
Prognostic Models ◽  
Related Gene ◽  
Cox Regression Analysis ◽  
Model Based ◽  
Immune Related Gene ◽  
Stomach Adenocarcinoma

Abstract Purpose: Stomach adenocarcinoma (STAD) is one of the most common malignant tumors, and its occurrence and prognosis are closely related to inflammation. The aim of the present study was to identify gene signatures and construct an immune-related gene (IRG) prognostic model in STAD using bioinformatics analysis. Methods: RNA sequencing data from healthy samples and samples with STAD, IRGs, and transcription factors were analyzed. The hub IRGs were identified using univariate and multivariate Cox regression analyses. Using the hub IRGs, we constructed an IRG prognostic model. The relationships between IRG prognostic models and clinical data were tested. Results: A total of 289 differentially expressed IRGs and 20 prognostic IRGs were screened with a threshold of P<0.05. Through multivariate stepwise Cox regression analysis, we developed a prognostic model based on seven IRGs. The prognostic model was validated using a GEO dataset (GSE 84437). The IRGs were significantly correlated with the clinical outcomes (age, histological grade, N, and M stage) of STAD patients. The infiltration abundances of dendritic cells and macrophages were higher in the high-risk group than in the low-risk group. Conclusions: Our results provide novel insights into the pathogenesis of STAD. An IRG prognostic model based on seven IRGs exhibited the predictive value, and have potential application value in clinical decision-making and individualized treatment.

Khat affects apoptosis and related gene XIAP and Smac expression following transient focal ischemia in rats

2010 ◽  
Vol 34 (8) ◽  
pp. S16-S16
Author(s):  
Fang‑fang Bi ◽  
Hadi M. Mujlli ◽  
Yue‑qiang Hu ◽  
Fa‑fa Tian ◽  
Zhi‑guo Wu ◽  
...  
Keyword(s):  
Focal Ischemia ◽  
Related Gene ◽  
Transient Focal Ischemia
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