scholarly journals Deletion of natriuretic peptide receptor C alleviates adipose tissue inflammation in hypercholesterolemic Apolipoprotein E knockout mice

2021 ◽  
Author(s):  
Cheng Cheng ◽  
Fei Xue ◽  
Wenhai Sui ◽  
Linlin Meng ◽  
Lin Xie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Apolipoprotein E ◽  
Natriuretic Peptide ◽  
Knockout Mice ◽  
Natriuretic Peptide Receptor ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Peptide Receptor ◽  
Apolipoprotein E Knockout Mice

scholarly journals Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 327
Author(s):  
Petros C. Dinas ◽  
Eleni Nintou ◽  
Dimitra Psychou ◽  
Marnie Granzotto ◽  
Marco Rossato ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Natriuretic Peptide ◽  
Fat Mass ◽  
Effect Size ◽  
Subcutaneous Adipose Tissue ◽  
Fat Free Mass ◽  
Natriuretic Peptide Receptor ◽  
Healthy Men ◽  
Peptide Receptor ◽  
Subcutaneous Adipose

Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m2)] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R2=0.16, p=0.03) and BMI (r=-0.45, R2=0.20, p=0.01). Cohen’s f2 effect size analyses showed a small effect size between NPRA mRNA and BMI (f2=0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m2) and either normal weight (BMI=19-25 kg/m2; d=0.94) or overweight (BMI=25-30 kg/m2; d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation.

scholarly journals Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yasunori Suematsu ◽  
Kohei Tashiro ◽  
Hidetaka Morita ◽  
Akihito Ideishi ◽  
Takashi Kuwano ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Natriuretic Peptide ◽  
Knockout Mice ◽  
Cardiac Dysfunction ◽  
High Fat Diet ◽  
Angiotensin Receptor Blocker ◽  
Left Ventricular ◽  
Angiotensin Receptor ◽  
High Fat ◽  
Apolipoprotein E Knockout Mice

Hypothesis. Myocardial angiogenesis is important for maintaining cardiac contractile function in patients with cardiac hypertrophy. Evidence shows that angiotensin receptor blocker and neprilysin inhibitors (ARNIs) improve heart failure. The present study investigated the myocardial angiogenic effect of valsartan plus sacubitril in early-stage cardiac dysfunction. Materials and Methods. Male apolipoprotein E-knockout mice fed a high-fat diet were divided into control (CTL), valsartan (30 mg/kg) (VAL), sacubitril (30 mg/kg) (SAC), and valsartan plus sacubitril (30 mg/kg each) (VAL/SAC) groups after 4 weeks of prefeeding and were subsequently treated for 12 weeks. Results. The VAL/SAC group exhibited significantly higher serum brain natriuretic peptide levels; more subtle changes in left ventricular systolic diameter, fractional shortening, and ejection fraction, and significantly higher expression levels of natriuretic peptide precursor B and markers of angiogenesis, including clusters of differentiation 34, vascular endothelial growth factor A, and monocyte chemotactic protein 1, than the CTL group. Conclusions. Valsartan plus sacubitril preserved left ventricular systolic function in apolipoprotein E-knockout mice fed a high-fat diet. This result suggests that myocardial angiogenic factors induced by ARNI might provide cardioprotective effects.

scholarly journals Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

Obesity ◽  
2016 ◽  
Vol 24 (4) ◽  
pp. 820-828 ◽  
Author(s):  
Zuzana Kovacova ◽  
William G. Tharp ◽  
Dianxin Liu ◽  
Wan Wei ◽  
Hui Xie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Natriuretic Peptide ◽  
Receptor Expression ◽  
Natriuretic Peptide Receptor ◽  
Peptide Receptor ◽  
Obesity And Diabetes

scholarly journals Visceral Adipose Tissue Inflammation Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice

Circulation ◽  
2008 ◽  
Vol 117 (6) ◽  
pp. 798-805 ◽  
Author(s):  
Miina K. Öhman ◽  
Yuechun Shen ◽  
Chinyere I. Obimba ◽  
Andrew P. Wright ◽  
Mark Warnock ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Apolipoprotein E ◽  
Visceral Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Inflammation ◽  
Visceral Adipose ◽  
Deficient Mice

Sarcolipin knockout mice fed a high-fat diet exhibit altered indices of adipose tissue inflammation and remodeling

Obesity ◽  
2016 ◽  
Vol 24 (7) ◽  
pp. 1499-1505 ◽  
Author(s):  
Rebecca E.K. MacPherson ◽  
Daniel Gamu ◽  
Scott Frendo-Cumbo ◽  
Laura Castellani ◽  
Frenk Kwon ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Knockout Mice ◽  
High Fat Diet ◽  
Adipose Tissue Inflammation ◽  
High Fat ◽  
Tissue Inflammation
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