scholarly journals Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes

Obesity ◽  
2016 ◽  
Vol 24 (4) ◽  
pp. 820-828 ◽  
Author(s):  
Zuzana Kovacova ◽  
William G. Tharp ◽  
Dianxin Liu ◽  
Wan Wei ◽  
Hui Xie ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Natriuretic Peptide ◽  
Receptor Expression ◽  
Natriuretic Peptide Receptor ◽  
Peptide Receptor ◽  
Obesity And Diabetes

scholarly journals Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 327
Author(s):  
Petros C. Dinas ◽  
Eleni Nintou ◽  
Dimitra Psychou ◽  
Marnie Granzotto ◽  
Marco Rossato ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Natriuretic Peptide ◽  
Fat Mass ◽  
Effect Size ◽  
Subcutaneous Adipose Tissue ◽  
Fat Free Mass ◽  
Natriuretic Peptide Receptor ◽  
Healthy Men ◽  
Peptide Receptor ◽  
Subcutaneous Adipose

Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.06±7.36, BMI: 27.60±4.63 (kg/m2)] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R2=0.16, p=0.03) and BMI (r=-0.45, R2=0.20, p=0.01). Cohen’s f2 effect size analyses showed a small effect size between NPRA mRNA and BMI (f2=0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen’s d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m2) and either normal weight (BMI=19-25 kg/m2; d=0.94) or overweight (BMI=25-30 kg/m2; d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation.

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