scholarly journals GLCCI1 reduces collagen deposition and airway hyper‐responsiveness in a mouse asthma model through binding with WD repeat domain 45B

2021 ◽  
Author(s):  
Qiufen Xun ◽  
Jiulong Kuang ◽  
Qing Yang ◽  
Wei Wang ◽  
Guofeng Zhu
Keyword(s):  
Collagen Deposition ◽  
Asthma Model ◽  
Repeat Domain ◽  
Wd Repeat

scholarly journals WD repeat domain 5 promotes chemoresistance and Programmed Death-Ligand 1 expression in prostate cancer

Theranostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 4809-4824
Author(s):  
Qianghua Zhou ◽  
Xu Chen ◽  
Haixia He ◽  
Shengmeng Peng ◽  
Yangjie Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Programmed Death Ligand 1 ◽  
Programmed Death ◽  
Repeat Domain ◽  
Wd Repeat

scholarly journals Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer

2018 ◽  
Vol 144 (7) ◽  
pp. 1584-1595 ◽  
Author(s):  
Yuncang Yuan ◽  
Guoxiang Qi ◽  
Hao Shen ◽  
Aizhen Guo ◽  
Fuao Cao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Biological Function ◽  
Repeat Domain ◽  
Wd Repeat

scholarly journals Autoantibody against WD repeat domain 1 is a novel serological biomarker for screening of thyroid neoplasia

2013 ◽  
Vol 79 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Shoichiro Izawa ◽  
Tomohisa Okamura ◽  
Kazuhiko Matsuzawa ◽  
Tsuyoshi Ohkura ◽  
Hiroko Ohkura ◽  
...  
Keyword(s):  
Thyroid Neoplasia ◽  
Repeat Domain ◽  
Wd Repeat

RACK1 (receptor for activated C-kinase 1) interacts with FBW2 (F-box and WD-repeat domain-containing 2) to up-regulate GCM1 (glial cell missing 1) stability and placental cell migration and invasion

2013 ◽  
Vol 453 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Chang-Chun Wang ◽  
Hsiao-Fan Lo ◽  
Shu-Yu Lin ◽  
Hungwen Chen
Keyword(s):  
Cell Migration ◽  
Glial Cell ◽  
Affinity Purification ◽  
Migration And Invasion ◽  
Placental Development ◽  
Placental Cell ◽  
Cell Migration And Invasion ◽  
Repeat Domain ◽  
Wd Repeats ◽  
Wd Repeat

GCM1 (glial cell missing 1) is a short-lived transcription factor essential for placental development. The F-box protein, FBW2 (F-box and WD-repeat domain-containing 2), which contains five WD (tryptophan–aspartate) repeats, recognizes GCM1 and mediates its ubiquitination via the SCFFBW2 E3 ligase complex. Although the interaction between GCM1 and FBW2 is facilitated by GCM1 phosphorylation, it is possible that this interaction might be regulated by additional cellular factors. In the present study, we perform tandem-affinity purification coupled with MS analysis identifying RACK1 (receptor for activated C-kinase 1) as an FBW2-interacting protein. RACK1 is a multifaceted scaffold protein containing seven WD repeats. We demonstrate that the WD repeats in both RACK1 and FBW2 are required for the interaction of RACK1 and FBW2. Furthermore, RACK1 competes with GCM1 for FBW2 and thereby prevents GCM1 ubiquitination, which is also supported by the observation that GCM1 is destabilized in RACK1-knockdown BeWo placental cells. Importantly, RACK1 knockdown leads to decreased expression of the GCM1 target gene HTRA4 (high-temperature requirement protein A4), which encodes a serine protease crucial for cell migration and invasion. As a result, migration and invasion activities are down-regulated in RACK1-knockdown BeWo cells. The present study reveals a novel function for RACK1 to regulate GCM1 activity and placental cell migration and invasion.

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