scholarly journals Clinical significance and biological function of WD repeat domain 54 as an oncogene in colorectal cancer

2018 ◽  
Vol 144 (7) ◽  
pp. 1584-1595 ◽  
Author(s):  
Yuncang Yuan ◽  
Guoxiang Qi ◽  
Hao Shen ◽  
Aizhen Guo ◽  
Fuao Cao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Biological Function ◽  
Repeat Domain ◽  
Wd Repeat

scholarly journals Clinical significance of Ankyrin repeat domain 12 expression in colorectal cancer

2013 ◽  
Vol 32 (1) ◽  
pp. 35 ◽  
Author(s):  
Rui Bai ◽  
Dan Li ◽  
Zhong Shi ◽  
Xuefeng Fang ◽  
Weiting Ge ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Ankyrin Repeat ◽  
Repeat Domain ◽  
Ankyrin Repeat Domain

scholarly journals F-Box/WD Repeat Domain-Containing 7 Induces Chemotherapy Resistance in Colorectal Cancer Stem Cells

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 635 ◽  
Author(s):  
Shusaku Honma ◽  
Shigeo Hisamori ◽  
Aya Nishiuchi ◽  
Yoshiro Itatani ◽  
Kazutaka Obama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Cycle ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Lines ◽  
Chemotherapy Resistance ◽  
Biopsy Specimens ◽  
Repeat Domain ◽  
Wd Repeat ◽  
Pre Treatment

Although the cancer stem cell (CSC) concept has provided a reasonable explanation for cancer recurrence following chemotherapy, the relationship between CSCs and chemotherapy resistance has not been thoroughly investigated, especially in solid tumors. We aimed to identify the mechanism underlying colorectal cancer (CRC) chemoresistance focusing on the cell cycle mediator F-Box/WD repeat domain-containing 7 (FBXW7). From 55 consecutive CRC cases who underwent neoadjuvant chemotherapy (NAC) or neoadjuvant chemoradiotherapy (NACRT) at Kyoto University Hospital, pre-treatment endoscopic biopsy specimens were collected and divided into two groups upon immunohistochemical (IHC) analysis: 21 cases of FBXW7 high expression (FBXW7-high group) and 34 cases of low expression (FBXW7-low group). High FBXW7 expression in pre-treatment biopsy specimen was significantly associated with poor pathological therapeutic effect (p = 0.019). The proportion of FBXW7-positive cells in surgically resected CRC specimens from patients who underwent NAC or NACRT was significantly higher than that in the pre-treatment biopsy specimens (p < 0.001). The expression of FBXW7 was inversely correlated with that of Ki67 in both pre-treatment biopsy specimens and surgically resected specimens. FBXW7 expression in the EpCAMhigh/CD44high subpopulation isolated by flow cytometry from CRC samples was significantly higher than that in the EpCAMhigh/CD44low subpopulation. Cell-cycle analysis in CRC cell lines revealed that, upon FBXW7 silencing, the proportion of G0/G1 cells was significantly lower than that in control cells. Moreover, knockdown of FBXW7 in CRC cell lines increased the sensitivity to anti-cancer drugs in vitro and in vivo. A subset of CRC stem cells possesses chemoresistance through FBXW7 expression. Cell cycle arrest induced by FBXW7 expression should be considered as a potential therapeutic target to overcome chemoresistance in CRC stem cell subsets.

Tu1920 Distinct Subcellular Localization of Phosphorylated ErbB2, ErbB3 and ErbB4 in Colorectal Cancer Cells and Their Relevance to Clinical Significance

2013 ◽  
Vol 144 (5) ◽  
pp. S-881
Author(s):  
Atsushi Tatsuguchi ◽  
Keigo Mitsui ◽  
Masaoki Yonezawa ◽  
Shu Tanaka ◽  
Shunji Fujimori ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Subcellular Localization ◽  
Cancer Cells ◽  
Clinical Significance ◽  
Colorectal Cancer Cells

scholarly journals The Clinical Significance of MiR-148a as a Predictive Biomarker in Patients with Advanced Colorectal Cancer

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46684 ◽  
Author(s):  
Masanobu Takahashi ◽  
Miriam Cuatrecasas ◽  
Francesc Balaguer ◽  
Keun Hur ◽  
Yuji Toiyama ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance ◽  
Advanced Colorectal Cancer ◽  
Predictive Biomarker

scholarly journals Clinical Significance of TROP2 Expression in Colorectal Cancer

2006 ◽  
Vol 12 (10) ◽  
pp. 3057-3063 ◽  
Author(s):  
Takahiro Ohmachi ◽  
Fumiaki Tanaka ◽  
Koshi Mimori ◽  
Hiroshi Inoue ◽  
Katsuhiko Yanaga ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Significance
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