scholarly journals Brahma‐Related Gene‐1 (BRG1) promotes the malignant phenotype of glioblastoma cells

2021 ◽  
Author(s):  
Yinan Wang ◽  
Chuan He Yang ◽  
Andrew P. Schultz ◽  
Michelle M. Sims ◽  
Duane D. Miller ◽  
...  
Keyword(s):  
Related Gene ◽  
Glioblastoma Cells ◽  
Malignant Phenotype

scholarly journals Liver-type glutaminase (GAB) suppresses malignant phenotype of glioblastoma cells

2017 ◽  
Vol 28 ◽  
pp. v601
Author(s):  
E.J. Majewska ◽  
M. Szeliga ◽  
J. Márquez ◽  
J. Albrecht
Keyword(s):  
Glioblastoma Cells ◽  
Malignant Phenotype

Ectopic Doublecortin Gene Expression Suppresses the Malignant Phenotype in Glioblastoma Cells

2006 ◽  
Vol 66 (24) ◽  
pp. 11726-11735 ◽  
Author(s):  
Manoranjan Santra ◽  
Xuepeng Zhang ◽  
Sutapa Santra ◽  
Feng Jiang ◽  
Michael Chopp
Keyword(s):  
Gene Expression ◽  
Glioblastoma Cells ◽  
Malignant Phenotype

scholarly journals Merkel cell carcinoma-derived exosome-shuttle miR-375 induces fibroblast polarization by inhibition of RBPJ and p53

Oncogene ◽  
2020 ◽  
Author(s):  
Kaiji Fan ◽  
Ivelina Spassova ◽  
Jan Gravemeyer ◽  
Cathrin Ritter ◽  
Kai Horny ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Cancer Associated Fibroblasts ◽  
Merkel Cell ◽  
Intercellular Signaling ◽  
Related Gene ◽  
Malignant Phenotype ◽  
Signaling Function

AbstractMerkel cell carcinoma (MCC) is a highly invasive and metastatic skin cancer. While high expression of miR-375 is a characteristic of MCC, it seems not to contribute to the malignant phenotype of MCC cells. miR-375 enrichment in MCC-derived extracellular vesicles suggests its intercellular signaling function. Here, we demonstrate that horizontally transferred miR-375 causes fibroblast polarization toward cancer-associated fibroblasts (CAFs). The polarization is evidenced by phenotypic changes and induction of α-SMA, CXCL2, and IL-1β. Fibroblast polarization is inhibited by specific antagomirs and mimicked by experimental miR-375 expression. Mechanistically, miR-375 downregulates RBPJ and p53, two key players regulating fibroblast polarization. In clinical MCC samples, in situ hybridization located miR-375 in CAFs, which correlated with high α-SMA protein and low RBPJ and TP53 expression; single-cell RNAseq revealed a disparate fibroblast polarization negatively correlating with p53 pathway-related gene expression. Thus, the functional role of miR-375 in MCC is to generate a pro-tumorigenic microenvironment by inducing fibroblast polarization.

Cisplatin downregulates BCL2L12, a novel apoptosis-related gene, in glioblastoma cells

2013 ◽  
Vol 49 (6) ◽  
pp. 465-472 ◽  
Author(s):  
Mahdieh Sadat Taghavi ◽  
Azim Akbarzadeh ◽  
Reza Mahdian ◽  
Kayhan Azadmanesh ◽  
Gholamreza Javadi
Keyword(s):  
Related Gene ◽  
Glioblastoma Cells ◽  
Apoptosis Related Gene

scholarly journals Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells

2014 ◽  
Vol 31 (4) ◽  
pp. 1761-1767 ◽  
Author(s):  
XIN HUANG ◽  
QIANGQIAN QI ◽  
XUMING HUA ◽  
XINYUAN LI ◽  
WENCHUAN ZHANG ◽  
...  
Keyword(s):  
Beclin 1 ◽  
Related Gene ◽  
Glioblastoma Cells

Khat affects apoptosis and related gene XIAP and Smac expression following transient focal ischemia in rats

2010 ◽  
Vol 34 (8) ◽  
pp. S16-S16
Author(s):  
Fang‑fang Bi ◽  
Hadi M. Mujlli ◽  
Yue‑qiang Hu ◽  
Fa‑fa Tian ◽  
Zhi‑guo Wu ◽  
...  
Keyword(s):  
Focal Ischemia ◽  
Related Gene ◽  
Transient Focal Ischemia
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