scholarly journals Identification of a prognostic gene signature based on an immunogenomic landscape analysis of bladder cancer

2020 ◽  
Vol 24 (22) ◽  
pp. 13370-13382
Author(s):  
Yongwen Luo ◽  
Liang Chen ◽  
Qiang Zhou ◽  
Yaoyi Xiong ◽  
Gang Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Gene Signature ◽  
Landscape Analysis ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

scholarly journals A novel pyroptosis-associated gene signature for immune status and prognosis of cutaneous melanoma

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e12304
Author(s):  
Zhengyuan Wu ◽  
Leilei Chen ◽  
Chaojie Jin ◽  
Jing Xu ◽  
Xingqun Zhang ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Immune Status ◽  
Immune Cell ◽  
Gene Signature ◽  
Gene Set Enrichment Analysis ◽  
Cell Infiltration ◽  
Immune Cell Infiltration ◽  
Tumor Cell Death ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

Background Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk. However, the prognostic value of pyroptosis-associated gene signatures in CM remains unclear. Methods Gene profiles and clinical data of patients with CM were downloaded from The Cancer Genome Atlas (TCGA) to identify differentially expressed genes associated with pyroptosis and overall survival (OS). We constructed a prognostic gene signature using LASSO analysis, then applied immune cell infiltration scores and Kaplan-Meier, Cox, and pathway enrichment analyses to determine the roles of the gene signature in CM. A validation cohort was collected from the Gene Expression Omnibus (GEO) database. Results Four pyroptosis-associated genes were identified and incorporated into a prognostic gene signature. Integrated bioinformatics findings showed that the signature correlated with patient survival and was associated with tumor growth and metastasis. The results of Gene Set Enrichment Analysis of a risk signature indicated that several enriched pathways are associated with cancer and immunity. The risk signature for immune status significantly correlated with tumor stem cells, the immune microenvironment, immune cell infiltration and immune subtypes. The expression of four pyroptosis genes significantly correlated with the OS of patients with CM and was related to the sensitivity of cancer cells to several antitumor drugs. A signature comprising four genes associated with pyroptosis offers a novel approach to the prognosis and survival of patients with CM and will facilitate the development of individualized therapy.

scholarly journals Immune Landscape of the Tumor Microenvironment Identifies Prognostic Gene Signature CD4/CD68/CSF1R in Osteosarcoma

2020 ◽  
Vol 10 ◽  
Author(s):  
Yi-jiang Song ◽  
Yanyang Xu ◽  
Xiaojun Zhu ◽  
Jianchang Fu ◽  
Chuangzhong Deng ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Gene Signature ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

575 Generation and Validation of a Prognostic Gene Signature for Esophageal Adenocarcinoma

2009 ◽  
Vol 136 (5) ◽  
pp. A-91
Author(s):  
Christopher J. Peters ◽  
Jonathan R. Rees ◽  
James S. Hardwick ◽  
Chunsheng Zhang ◽  
Richard H. Hardwick ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Gene Signature ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

scholarly journals Multiomics profile and prognostic gene signature of m6A regulators in uterine corpus endometrial carcinoma

2020 ◽  
Vol 11 (21) ◽  
pp. 6390-6401 ◽  
Author(s):  
Yizi Wang ◽  
Fang Ren ◽  
Zixuan Song ◽  
Xiaoying Wang ◽  
Xiaoxin Ma
Keyword(s):  
Endometrial Carcinoma ◽  
Gene Signature ◽  
Uterine Corpus ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

Abstract 558: Prognostic gene signature use in checkpoint inhibitor monotherapy for melanoma

2018 ◽  
Author(s):  
Mariaelena Capone ◽  
Gabriele Madonna ◽  
Paolo Ascierto ◽  
Patrick Danaher ◽  
SuFey Ong ◽  
...  
Keyword(s):  
Checkpoint Inhibitor ◽  
Gene Signature ◽  
Prognostic Gene ◽  
Prognostic Gene Signature
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