scholarly journals Identification of an apoptosis-related prognostic gene signature and molecular subtypes of clear cell renal cell carcinoma (ccRCC)

2021 ◽  
Vol 12 (11) ◽  
pp. 3265-3276
Author(s):  
Weimin Zhong ◽  
Fengling Zhang ◽  
Chaoqun Huang ◽  
Yao Lin ◽  
Jiyi Huang
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Molecular Subtypes ◽  
Gene Signature ◽  
Cell Renal Cell Carcinoma ◽  
Prognostic Gene ◽  
Prognostic Gene Signature

scholarly journals Development of a novel gene signature to predict prognosis and response to PD-1 blockade in clear cell renal cell carcinoma

2021 ◽  
Vol 10 (1) ◽  
pp. 1933332
Author(s):  
Xiaomao Yin ◽  
Zaoyu Wang ◽  
Jianfeng Wang ◽  
Yunze Xu ◽  
Wen Kong ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Gene Signature ◽  
Cell Renal Cell Carcinoma ◽  
Novel Gene

scholarly journals MP72-17 THE ASSOCIATION BETWEEN SARCOPENIA AND MOLECULAR SUBTYPES OF CLEAR CELL RENAL CELL CARCINOMA

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Alejandro Sanchez ◽  
Stacey Petruzella ◽  
Marguerite Samson ◽  
Oguz Akin ◽  
Michael Paris ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Molecular Subtypes ◽  
Cell Renal Cell Carcinoma

A prognostic nomogram based on competing endogenous RNA network for clear-cell renal cell carcinoma

2020 ◽  
Author(s):  
Yun Peng ◽  
Shangrong Wu ◽  
Zihan Xu ◽  
Dingkun Hou ◽  
Nan Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Rna Sequencing ◽  
Renal Cell ◽  
Cox Regression ◽  
Clear Cell ◽  
Gene Signature ◽  
Expression Data ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma

Abstract Backgroud Clear-cell renal cell carcinoma (ccRCC) is stubborn to traditional chemotherapy and radiation treatment, which makes its clinical management a major challenge. Recently, we have made efforts to understand the etiology of ccRCC. Increasing evidence revealed that the competing endogenous RNA (ceRNA) were involved in the development of various tumor. However, it’s scant for studying on ccRCC, and a comprehensive analysis of prognostic model based on lncRNA-miRNA-mRNA ceRNA regulatory network of ccRCC with large-scale sample size and RNA‐sequencing expression data is still limited. Methods RNA‐sequencing expression data were taken out from GTEx database and TCGA database, A total of 354 samples with ccRCC and 157 normal controlled samples were included in our study. The ccRCC-specific genes were obtained from WGCNA and differential expression analysis. Following, the communication between mRNAs and lncRNAs and target miRNAs were predicted by MiRcode, starBase, miRTarBase, and TargetScan. A gene signature of eight genes was constructed by univariate Cox regression, lasso methods and multivariate Cox regression analysis. Results A total of 2191 mRNAs and 1377 lncRNAs was identified, and a dys-regulated ceRNA network for ccRCC was established using 7 mRNAs, 363 lncRNAs, and 3 miRNAs. Further, a gene signature in cluding 8 genes based on this ceRNA was constructed, meanwhile, a nomogram predicting 1-, 3-, 5-year survival probability containing both clinical characteristics and ccRCC-specific gene signatures was developed. Conclusion It could contribute to a better understanding of ccRCC tumorigenesis mechanism and guide clinicians to make a more accurate treatment decision.

scholarly journals A four-gene signature predicts survival in clear-cell renal-cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (50) ◽  
pp. 82712-82726 ◽  
Author(s):  
Jun Dai ◽  
Yuchao Lu ◽  
Jinyu Wang ◽  
Lili Yang ◽  
Yingyan Han ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Gene Signature ◽  
Cell Renal Cell Carcinoma

scholarly journals The Three-Gene Signature in Urinary Extracellular Vesicles from Patients with Clear Cell Renal Cell Carcinoma

2016 ◽  
Vol 7 (14) ◽  
pp. 1960-1967 ◽  
Author(s):  
Giuseppe De Palma ◽  
Fabio Sallustio ◽  
Claudia Curci ◽  
Vanessa Galleggiante ◽  
Monica Rutigliano ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Extracellular Vesicles ◽  
Renal Cell ◽  
Clear Cell ◽  
Gene Signature ◽  
Cell Renal Cell Carcinoma

scholarly journals Identification of gene signature for treatment response to guide precision oncology in clear-cell renal cell carcinoma

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ninadh M. D’Costa ◽  
Davide Cina ◽  
Raunak Shrestha ◽  
Robert H. Bell ◽  
Yen-Yi Lin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Treatment Response ◽  
Renal Cell ◽  
Clear Cell ◽  
Gene Signature ◽  
Precision Oncology ◽  
Cell Renal Cell Carcinoma
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