AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway

Zhan‐Fei Zhang; Tie‐Jun Huang; Xin‐Ke Zhang; Yu‐Jie Xie; Si‐Ting Lin; Fei‐Fei Luo; Dong‐Fang Meng; Hao Hu; Jing Wang; Li‐Xia Peng; Chao‐Nan Qian; Chao Cheng; Bi‐Jun Huang

doi:10.1111/jcmm.15604

AKR1C2 acts as a targetable oncogene in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway

Journal of Cellular and Molecular Medicine ◽

10.1111/jcmm.15604 ◽

2020 ◽

Vol 24 (17) ◽

pp. 9999-10012

Author(s):

Zhan‐Fei Zhang ◽

Tie‐Jun Huang ◽

Xin‐Ke Zhang ◽

Yu‐Jie Xie ◽

Si‐Ting Lin ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway

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HPV16 E6-E7 Induces Cancer Stem-like Cell Phenotypes and Chemoradioresistance in Esophageal Squamous Cell Carcinoma Through Activation of PI3K/Akt Signaling Pathway

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2016.06.2027 ◽

2016 ◽

Vol 96 (2) ◽

pp. E559

Author(s):

S. Che ◽

R. Xi ◽

S. Pan ◽

X. Chen ◽

B. Hui ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Hpv16 E6 ◽

Cell Phenotypes

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Knockdown of EphB3 inhibits cell proliferation partly through the AKT signaling pathway and represses epithelial-mesenchymal transition in esophageal squamous cell carcinoma

Translational Cancer Research ◽

10.21037/tcr-21-1567 ◽

2021 ◽

Vol 0 (0) ◽

pp. 0-0

Author(s):

Luqun Tang ◽

Lijun Wang ◽

Tao Yu ◽

Tongpeng Xu ◽

Lizhen Zhang ◽

...

Keyword(s):

Cell Proliferation ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Epithelial Mesenchymal Transition ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Mesenchymal Transition

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Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

Oncotarget ◽

10.18632/oncotarget.16333 ◽

2017 ◽

Vol 8 (24) ◽

pp. 38755-38766 ◽

Cited By ~ 35

Author(s):

Bin Li ◽

Wen Wen Xu ◽

Alfred King Y. Lam ◽

Yang Wang ◽

Hui-Fang Hu ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Metastasis Therapy

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Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells

Journal of Cancer ◽

10.7150/jca.58023 ◽

2021 ◽

Vol 12 (16) ◽

pp. 5013-5024

Author(s):

Naiyi Zou ◽

Xueyuan Zhang ◽

Shuguang Li ◽

Youmei Li ◽

Yan Zhao ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Radiation Resistance ◽

Akt Signaling ◽

Carcinoma Cells ◽

Akt Signaling Pathway

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ITGA2 Overexpression Promotes Esophageal Squamous Cell Carcinoma Aggression via FAK/AKT Signaling Pathway

OncoTargets and Therapy ◽

10.2147/ott.s302028 ◽

2021 ◽

Vol Volume 14 ◽

pp. 3583-3596

Author(s):

Wei Huang ◽

Ju Zhu ◽

Haoming Shi ◽

Qingchen Wu ◽

Cheng Zhang

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway

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CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2018.11.273 ◽

2019 ◽

Vol 125 ◽

pp. 116-123 ◽

Cited By ~ 11

Author(s):

Yunlong He ◽

E. Mingyan ◽

Chunbo Wang ◽

Guohui Liu ◽

Manru Shi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Tumor Progression ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway

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CDKN3 promotes cell proliferation, invasion and migration by activating the AKT signaling pathway in esophageal squamous cell carcinoma

Oncology Letters ◽

10.3892/ol.2019.11077 ◽

2019 ◽

Author(s):

Hanxu Yu ◽

Jun Yao ◽

Mingyu Du ◽

Jinjun Ye ◽

Xia He ◽

...

Keyword(s):

Cell Proliferation ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Invasion And Migration ◽

And Migration

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Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARγ-Akt signaling pathway at the early stage of carcinogenesis

Oncotarget ◽

10.18632/oncotarget.21437 ◽

2017 ◽

Vol 8 (56) ◽

pp. 95914-95930 ◽

Cited By ~ 5

Author(s):

Miao Xu ◽

Hui Yang ◽

Qiannan Zhang ◽

Ping Lu ◽

Yongquan Feng ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Early Stage ◽

Akt Signaling ◽

Alpha Tocopherol ◽

Akt Signaling Pathway

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Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.03.106 ◽

2018 ◽

Vol 102 ◽

pp. 502-509 ◽

Cited By ~ 17

Author(s):

Xinbing Zhu ◽

Zhengzheng Li ◽

Tongtong Li ◽

Fei Long ◽

Yuesheng Lv ◽

...

Keyword(s):

Cell Cycle ◽

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Cell Cycle Arrest ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Cycle Arrest

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HPV16 E6-E7 induces cancer stem-like cells phenotypes in esophageal squamous cell carcinoma through the activation of PI3K/Akt signaling pathway in vitro and in vivo

Oncotarget ◽

10.18632/oncotarget.10959 ◽

2016 ◽

Vol 7 (35) ◽

pp. 57050-57065 ◽

Cited By ~ 20

Author(s):

Ruxing Xi ◽

Shupei Pan ◽

Xin Chen ◽

Beina Hui ◽

Li Zhang ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Esophageal Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Signaling Pathway ◽

Squamous Cell ◽

Akt Signaling ◽

Akt Signaling Pathway ◽

Hpv16 E6

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