scholarly journals IL‐17A‐producing T cells exacerbate fine particulate matter‐induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR‐mediated autophagy

2020 ◽  
Vol 24 (15) ◽  
pp. 8532-8544 ◽  
Author(s):  
Lu‐Hong Cong ◽  
Tao Li ◽  
Hui Wang ◽  
Yi‐Na Wu ◽  
Shu‐Peng Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Particulate Matter ◽  
Lung Inflammation ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals Regulatory T Cells Protect Fine Particulate Matter-Induced Inflammatory Responses in Human Umbilical Vein Endothelial Cells

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Wen-cai Zhang ◽  
Yan-ge Wang ◽  
Zheng-feng Zhu ◽  
Fang-qin Wu ◽  
Yu-dong Peng ◽  
...  
Keyword(s):  
T Cells ◽  
Endothelial Cells ◽  
Particulate Matter ◽  
Inflammatory Cytokines ◽  
Fine Particles ◽  
Inflammatory Responses ◽  
Umbilical Vein ◽  
Fine Particulate Matter ◽  
Fine Particulate ◽  
Umbilical Vein Endothelial Cells

Objective. To investigate the role of CD4+CD25+T cells (Tregs) in protecting fine particulate matter (PM-) induced inflammatory responses, and its potential mechanisms.Methods. Human umbilical vein endothelial cells (HUVECs) were treated with graded concentrations (2, 5, 10, 20, and 40 µg/cm2) of suspension of fine particles for 24h. For coculture experiment, HUVECs were incubated alone, with CD4+CD25−T cells (Teff), or with Tregs in the presence of anti-CD3 monoclonal antibodies for 48 hours, and then were stimulated with or without suspension of fine particles for 24 hours. The expression of adhesion molecules and inflammatory cytokines was examined.Results. Adhesion molecules, including vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), and inflammatory cytokines, such as interleukin (IL-) 6 and IL-8, were increased in a concentration-dependent manner. Moreover, the adhesion of human acute monocytic leukemia cells (THP-1) to endothelial cells was increased and NF-κB activity was upregulated in HUVECs after treatment with fine particles. However, after Tregs treatment, fine particles-induced inflammatory responses and NF-κB activation were significantly alleviated. Transwell experiments showed that Treg-mediated suppression of HUVECs inflammatory responses impaired by fine particles required cell contact and soluble factors.Conclusions. Tregs could attenuate fine particles-induced inflammatory responses and NF-κB activation in HUVECs.

Involvement of EGF receptor signaling and NLRP12 inflammasome in fine particulate matter-induced lung inflammation in mice

2016 ◽  
Vol 32 (4) ◽  
pp. 1121-1134 ◽  
Author(s):  
Yuefei Jin ◽  
Weidong Wu ◽  
Weiguo Zhang ◽  
Yang Zhao ◽  
Yongjun Wu ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Lung Inflammation ◽  
Egf Receptor ◽  
Fine Particulate Matter ◽  
Receptor Signaling ◽  
Fine Particulate

Effects of exposure of T cells to fine particulate matter and the influence of age; a prospective pilot study

2018 ◽  
Vol 295 ◽  
pp. S181
Author(s):  
M. Al Zallouha ◽  
S. Billet ◽  
Y. Landkocz ◽  
M. Borgie ◽  
S. Poddighe ◽  
...  
Keyword(s):  
T Cells ◽  
Particulate Matter ◽  
Pilot Study ◽  
Fine Particulate Matter ◽  
Prospective Pilot Study ◽  
Fine Particulate

scholarly journals Fine particulate matter-induced lung inflammation is mediated by pyroptosis in mice

2021 ◽  
Vol 219 ◽  
pp. 112351
Author(s):  
Juan Li ◽  
Zhen An ◽  
Jie Song ◽  
Jinge Du ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Lung Inflammation ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5)

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Mengmeng Xu ◽  
Yanbei Zhang ◽  
Muyun Wang ◽  
Hai Zhang ◽  
Yuqing Chen ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Airway Hyperresponsiveness ◽  
Lung Inflammation ◽  
Transient Receptor Potential ◽  
Fine Particulate Matter ◽  
Receptor Potential ◽  
Inflammatory Infiltration ◽  
Caspase 1 ◽  
Trpv1 Channels ◽  
Fine Particulate

Exposure to fine particulate matter (PM2.5) has been associated with lung inflammation and airway hyperresponsiveness (AHR). Transient receptor potential (TRP) vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) both may play important roles in lung inflammation and AHR. We investigated whether PM2.5-induced lung inflammation and AHR could be prevented by blocking TRPV1 and TRPA1 channels. Mice were injected intraperitoneally with AMG9810 (30 mg/kg, a TRPV1 antagonist) or A967079 (30 mg/kg, a TRPA1 antagonist) or their combination or vehicle (PBS) one hour before intranasal instillation of PM2.5 (7.8 mg/kg) or vehicle (PBS) for two consecutive days, and then the mice were studied 24 h later. All pretreatments inhibited PM2.5-induced AHR and inflammatory infiltration in the lung tissue and decreased inflammatory cytokine levels in the bronchoalveolar lavage fluid, together with oxidant levels in the lung. AMG9810 inhibited MFF expression and increased MFN2 expression while A967079 inhibited DRP1 expression and increased OPA1 expression; combined pretreatment reduced MFF and DPR1 expression and increased MFN2 and OPA1 expression. All pretreatments inhibited the activation of the TLR4/NF-κB pathway, while A967079 alone, and combined with AMG9810 also reduced the activation of the NLRP3/caspase-1 pathway. Both TRPV1 and TRPA1 channels play an important role in PM2.5-induced lung inflammation and AHR. However, inhibition of the TRPA1 channel or combined inhibition of TRPA1 and TRPV1 channels resulted in greater inhibitory effect on PM2.5-induced lung injury through regulating the mitochondrial fission/fusion proteins and inhibiting the TLR4/NF-κB and NLRP3/caspase-1 pathways.

The Mortality Impact of Fine Particulate Matter in China

2020 ◽  
Author(s):  
Yazhen Gong ◽  
Shanjun Li ◽  
Nicholas Sanders ◽  
Guang Shi
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate

Size-fractionated Electrochemical Quantification for Compact Monitoring of Fine Particulate Matter

2021 ◽  
pp. 106386
Author(s):  
Heyu Yin ◽  
Sina Parsnejad ◽  
Ehsan Ashoori ◽  
Hao Wan ◽  
Wen Li ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate
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