scholarly journals Integrative transcriptomic and proteomic analysis reveals CD9/ITGA4/PI3K‐Akt axis mediates trabecular meshwork cell apoptosis in human glaucoma

2020 ◽  
Vol 24 (1) ◽  
pp. 814-829
Author(s):  
Junwei Yan ◽  
Xuejiao Yang ◽  
Xuefei Jiao ◽  
Xian Yang ◽  
Mingjin Guo ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Cell Apoptosis ◽  
Proteomic Analysis ◽  
Trabecular Meshwork Cell

scholarly journals MiR-181a inhibits human trabecular meshwork cell apoptosis induced by H₂O₂ through the suppression of NF-κB and JNK pathways

2018 ◽  
Vol 27 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Yuwen Wang ◽  
Heding Zhou ◽  
Xiaotian Liu ◽  
Yin Han ◽  
Suqi Pan ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Cell Apoptosis ◽  
Trabecular Meshwork Cell

Circumferential trabecular meshwork cell density in the human eye

2021 ◽  
Vol 205 ◽  
pp. 108494
Author(s):  
Markus H. Kuehn ◽  
Janice A. Vranka ◽  
David Wadkins ◽  
Thomas Jackson ◽  
Lin Cheng ◽  
...  
Keyword(s):  
Cell Density ◽  
Trabecular Meshwork ◽  
Human Eye ◽  
Trabecular Meshwork Cell

scholarly journals Cyclic Mechanical Stress and Trabecular Meshwork Cell Contractility

2009 ◽  
Vol 50 (8) ◽  
pp. 3826 ◽  
Author(s):  
Renata F. Ramos ◽  
Grant M. Sumida ◽  
W. Daniel Stamer
Keyword(s):  
Mechanical Stress ◽  
Trabecular Meshwork ◽  
Cell Contractility ◽  
Trabecular Meshwork Cell

scholarly journals SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress

2020 ◽  
Author(s):  
Sizhen Li ◽  
Qingsong Yang ◽  
Zixiu Zhou ◽  
Min Fu ◽  
Xiaodong Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Extracellular Matrix ◽  
Intraocular Pressure ◽  
Oxidative Damage ◽  
Trabecular Meshwork ◽  
Cell Apoptosis ◽  
Cell Injury ◽  
Quantitative Polymerase Chain Reaction ◽  
Subcellular Fractionation ◽  
Cell Counting

Abstract Background: Glaucoma is the main reason for irreversible blindness, and pathological increased intraocular pressure is the leading risk factor for glaucoma. It is reported that trabecular meshwork cell injury is closely associated with the elevated intraocular pressure. The current study aimed to investigate the role of SNHG3 in human trabecular meshwork (HTM) cells under oxidative stress. Methods: A series of experiments including real-time quantitative polymerase chain reaction (RT-qPCR), subcellular fractionation assay, western blot analysis, cell counting kit-8 (CCK-8) assay, RNA pull down, flow cytometry analysis, and RIP assay were employed to explore the biological function and regulatory mechanism of SNHG3 in HTM cells under oxidative stress.Results: First, we observed that H2O2 induced SNHG3 upregulation in HTM cells. Then, we found that SNHG3 silencing alleviated H2O2-induced oxidative damage in HTM cells. Moreover, SNAI2 knockdown alleviated the oxidative damage induced by H2O2 in HTM cells. Mechanistically, SNHG3 bound with ELAVL2 to stabilize SNAI2. Finally, SNAI2 overexpression counteracted the effect of SNHG3 silencing on H2O2-induced HTM cells. Conclusion: Our results demonstrated that SNHG3 cooperated with ELAVL2 to modulate cell apoptosis and extracellular matrix (ECM) accumulation by stabilizing SNAI2 in HTM cells under oxidative stress.

Caveolin‐1 regulates human trabecular meshwork cell adhesion, endocytosis, and autophagy

2019 ◽  
Vol 120 (8) ◽  
pp. 13382-13391 ◽  
Author(s):  
Zhenggen Wu ◽  
Chukai Huang ◽  
Ciyan Xu ◽  
Lijing Xie ◽  
Jia‐Jian Liang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Trabecular Meshwork ◽  
Caveolin 1 ◽  
Trabecular Meshwork Cell
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