scholarly journals Attenuation of diabetic cardiomyopathy by relying on kirenol to suppress inflammation in a diabetic rat model

2019 ◽  
Vol 23 (11) ◽  
pp. 7651-7663 ◽  
Author(s):  
Bin Wu ◽  
Xue‐Yuan Huang ◽  
Le Li ◽  
Xiao‐Hang Fan ◽  
Peng‐Cheng Li ◽  
...  
Keyword(s):  
Diabetic Cardiomyopathy ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model

AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model

Life Sciences ◽  
2019 ◽  
Vol 221 ◽  
pp. 249-258 ◽  
Author(s):  
Xuyang Wang ◽  
Jinyu Pan ◽  
Hui Liu ◽  
Mingjun Zhang ◽  
Dian Liu ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Diabetic Cardiomyopathy ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

scholarly journals TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model

Diabetes ◽  
2011 ◽  
Vol 60 (11) ◽  
pp. 2963-2974 ◽  
Author(s):  
Yun Ti ◽  
Guo-lu Xie ◽  
Zhi-hao Wang ◽  
Xiao-lei Bi ◽  
Wen-yuan Ding ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Diabetic Cardiomyopathy ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

Exploration of the Effect and Mechanism of ShenQi Compound in a Spontaneous Diabetic Rat Model

2019 ◽  
Vol 19 (5) ◽  
pp. 622-631 ◽  
Author(s):  
Ya Liu ◽  
Jian Kang ◽  
Hong Gao ◽  
Xiyu Zhang ◽  
Jun Chao ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Signaling Pathway ◽  
Rat Model ◽  
Mtor Signaling ◽  
Diabetic Rat ◽  
Gene Microarray ◽  
Mtor Signaling Pathway ◽  
Glucose Fluctuation ◽  
Blood Glucose Fluctuation ◽  
Diabetic Rat Model

Background: Type 2 Diabetes Mellitus (T2DM) is a world-wide metabolic disease with no cure from drugs and treatment. In China, The Traditional Chinese Medicine (TCM) herbal formulations have been used to treat T2DM for centuries. Methods: In this study, we proposed a formula called ShenQi Compound (SQC), which has been used in clinical therapeutics in China for several years. We evaluated the effect of SQC in a spontaneous diabetic rat model (GK rats) by detecting a series of blood indicators and performing histological observations. Meanwhile, the gene microarray and RT-qPCR experiments were used to explore the molecular mechanism of SQC treatment. In addition, western medicine, sitagliptin was employed as a comparison. Results: The results indicated that SQC and sitagliptin could effectively improve the serum lipid (blood Total Cholesterol (TC) and blood Triglycerides (TG)), hormone levels (serum insulin (INS), Glucagon (GC) and Glucagon-Like Peptide-1 (GLP-1)), alleviated the inflammatory response (hypersensitive C-Reactive Protein (hsCRP)), blood glucose fluctuation (Mean Blood Glucose (MBG), standard deviation of blood glucose (SDBG) and Largest Amplitude of plasma Glucose Excursions (LAGE)), pancreatic tissue damage and vascular injury for T2DM. Compared with sitagliptin, SQC achieved a better effect on blood glucose fluctuation (p<0.01). Meanwhile, the gene microarray and RT-qPCR experiments indicated that SQC and sitagliptin may improve the T2DM through affecting the biological functions related to apoptosis and circadian rhythm. Moreover, SQC might be able to influence the mTOR signaling pathway by regulating Pik3r1, Ddit4 expression. Conclusion: All these results indicate that SQC is an effective therapeutic drug on T2DM. Notably, SQC presents an obvious blood glucose fluctuation-preventing ability, which might be derived from the regulation of the mTOR signaling pathway.

scholarly journals Jinmaitong decreases sciatic nerve DNA oxidative damage and apoptosis in a streptozotocin-induced diabetic rat model

2015 ◽  
Vol 10 (2) ◽  
pp. 778-786 ◽  
Author(s):  
DE-HAI YIN ◽  
XIAO-CHUN LIANG ◽  
LI ZHAO ◽  
HONG ZHANG ◽  
QING SUN ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Oxidative Damage ◽  
Rat Model ◽  
Diabetic Rat ◽  
Dna Oxidative Damage ◽  
Diabetic Rat Model

scholarly journals COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model

2013 ◽  
Vol 28 (5) ◽  
pp. 725 ◽  
Author(s):  
Sun-Ouck Kim ◽  
Hyun-Suk Lee ◽  
Kyuyoun Ahn ◽  
Kwangsung Park
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic ◽  
Angiopoietin 1

Effect ofCostus spiralis(Jacq.)RoscoeLeaves, Methanolic Extract and Guaijaverin on Blood Glucose and Lipid Levels in a Type II Diabetic Rat Model

2019 ◽  
Vol 16 (1) ◽  
pp. e1800365
Author(s):  
Regiane C. Duarte ◽  
Silvia H. Taleb-Contini ◽  
Paulo S. Pereira ◽  
Camila F. Oliveira ◽  
Carlos Eduardo S. Miranda ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Rat Model ◽  
Methanolic Extract ◽  
Diabetic Rat ◽  
Type Ii ◽  
Lipid Levels ◽  
Diabetic Rat Model

The effect of copper deficiency on fetal growth and liver anti-oxidant capacity in the Cohen diabetic rat model

2012 ◽  
Vol 265 (2) ◽  
pp. 209-220 ◽  
Author(s):  
Zivanit Ergaz ◽  
Dana Shoshani-Dror ◽  
Claire Guillemin ◽  
Meytal Neeman-azulay ◽  
Liza Fudim ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Rat Model ◽  
Copper Deficiency ◽  
Diabetic Rat ◽  
Anti Oxidant ◽  
Effect Of Copper ◽  
Diabetic Rat Model

Improvements of Glucose and Lipid Metabolism After Jejuno-ileal Circuit Procedure in a Non-obese Diabetic Rat Model

2015 ◽  
Vol 26 (8) ◽  
pp. 1768-1776 ◽  
Author(s):  
Yanmin Wang ◽  
Xiang Zhang ◽  
Mingwei Zhong ◽  
Teng Liu ◽  
Guangyong Zhang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Rat Model ◽  
Diabetic Rat ◽  
Glucose And Lipid Metabolism ◽  
Diabetic Rat Model
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