scholarly journals Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis

2019 ◽  
Vol 23 (4) ◽  
pp. 2362-2371 ◽  
Author(s):  
Maria Troullinaki ◽  
Vasileia‐Ismini Alexaki ◽  
Ioannis Mitroulis ◽  
Anke Witt ◽  
Anne Klotzsche–von Ameln ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Survival ◽  
Nerve Growth ◽  
Endothelial Cell Survival ◽  
Retinal Angiogenesis

scholarly journals NF-κB Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells

2000 ◽  
Vol 20 (20) ◽  
pp. 7556-7563 ◽  
Author(s):  
Erik D. Foehr ◽  
Xin Lin ◽  
Alison O'Mahony ◽  
Romas Geleziunas ◽  
Ralph A. Bradshaw ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Survival ◽  
Pc12 Cells ◽  
Nerve Growth ◽  
Process Formation

Autocrine nerve growth factor is essential for cell survival and viral maturation in HHV-8–infected primary effusion lymphoma cells

Blood ◽  
2000 ◽  
Vol 95 (9) ◽  
pp. 2905-2912 ◽  
Author(s):  
Francesca Pica ◽  
Antonio Volpi ◽  
Annalucia Serafino ◽  
Marzia Fraschetti ◽  
Ornella Franzese ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
B Cell ◽  
Cell Survival ◽  
Cell Lines ◽  
Primary Effusion Lymphoma ◽  
Human Herpesvirus ◽  
Lytic Cycle ◽  
Nerve Growth ◽  
Barr Virus

High levels of nerve growth factor (NGF) are found in sera from individuals infected with human herpesvirus 8 (HHV-8). BC-1 and BCBL-1 cells are primary effusion lymphoma–derived B-cell lines; BC-1 cells are infected by HHV-8 and the Epstein-Barr virus (EBV), and BCBL-1 cells are infected only by HHV-8. Both cells express NGF receptors and produce NGF, whereas RAMOS cells (a B-cell line that is negative for HHV-8 and EBV) express NGF receptors but do not produce detectable NGF. Neutralization of endogenous NGF results in cell growth inhibition and apoptosis in BCBL-1 cells and, to a minor extent, in BC-1 cells. When the HHV-8 lytic cycle is induced in BCBL-1 cells by tetradecanoyl phorbol acetate (TPA), an initial reduction of endogenous NGF production is observed, and many cells undergo apoptosis. However, at 48 hours, TPA-treated cells produce significantly more NGF than untreated controls, and a subsequent recovery of cell viability is observed. Consistent with this finding, the addition of exogenous NGF or anti-NGF antibodies to TPA-treated cells reduces or increases, respectively, the rate of apoptosis in response to TPA. Finally, electron microscopy of TPA-treated BCBL-1 cells shows that the addition of exogenous NGF increases the number of cells producing and releasing complete virions as compared with the controls (25% versus 5%). On the contrary, NGF neutralization leads to the production of defective viral progeny in about 2% of cells. These data indicate that NGF is essential for both cell survival and virus maturation in HHV-8–infected cell lines.

scholarly journals Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

1998 ◽  
Vol 18 (9) ◽  
pp. 3273-3281 ◽  
Author(s):  
Sung Ok Yoon ◽  
Patrizia Casaccia-Bonnefil ◽  
Bruce Carter ◽  
Moses V. Chao
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Survival ◽  
Growth Factor Receptors ◽  
Nerve Growth ◽  
Nerve Growth Factor Receptors
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