Phosphoinositide-specific phospholipase C?1 expression is not linked to nerve growth factor-induced differentiation, cell survival or cell cycle control in PC12 rat pheocromocytoma cells

2001 ◽  
Vol 84 (1) ◽  
pp. 56-67 ◽  
Author(s):  
Roberta Bortul ◽  
Michela Aluigi ◽  
Pier Luigi Tazzari ◽  
Giovanna Tabellini ◽  
Giovanna Baldini ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Survival ◽  
Phospholipase C ◽  
Cell Cycle Control ◽  
Induced Differentiation ◽  
Nerve Growth

scholarly journals Src Homology Domains of Phospholipase C γ1 Inhibit Nerve Growth Factor-Induced Differentiation of PC12 Cells

2002 ◽  
Vol 71 (1) ◽  
pp. 178-185 ◽  
Author(s):  
Sun Sik Bae ◽  
Young Han Lee ◽  
Jong-Soo Chang ◽  
Sehamuddin H. Galadari ◽  
Yong Sik Kim ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Phospholipase C ◽  
Pc12 Cells ◽  
Induced Differentiation ◽  
Nerve Growth ◽  
Src Homology ◽  
Src Homology Domains ◽  
Homology Domains

scholarly journals Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells.

1993 ◽  
Vol 4 (4) ◽  
pp. 353-361 ◽  
Author(s):  
D Kalman ◽  
K Whittaker ◽  
J M Bishop ◽  
P H O'Lague
Keyword(s):  
Cell Cycle ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Cell Cycle Control ◽  
Susceptibility Gene ◽  
Signal Transduction Pathway ◽  
Control Mechanisms ◽  
Nerve Growth

Nerve growth factor (NGF) causes PC12 cells to cease division and undergo sympathetic neuron-like differentiation, including neurite outgrowth. We have tested whether differentiation and division share overlapping control mechanisms in these cells. To do this, we have perturbed the activity of proteins known to participate in cell-cycle regulation by introducing the E1A oncogene or its mutant forms via microinjection into PC12 cells. The E1A protein binds to several putative cell cycle control proteins, including p105Rb (the product of the retinoblastoma susceptibility gene), as well as others of unknown function such as p130, p107, and p300. Similar to previous results, we find that wild-type E1A abrogates NGF-induced neurite extension. However, NGF does cause neurite outgrowth in the presence of E1A mutants known to have greatly reduced binding to either p105Rb and p130 or p300. Our experiments suggest that p105Rb, p130, and p300 may participate either in E1A-mediated inhibition of differentiation or in the NGF signal transduction pathway. We also report here that NGF affects phosphorylation of p105Rb, suggesting that Rb mediates at least some of NGF's effects. Our results raise the possibility that putative cell-cycle control proteins may participate not only in NGF-induced cessation of division but also in differentiation.

scholarly journals Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 ◽  
Vol 266 (3) ◽  
pp. 1359-1362 ◽  
Author(s):  
U H Kim ◽  
D Fink ◽  
H S Kim ◽  
D J Park ◽  
M L Contreras ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Phospholipase C ◽  
Pc12 Cells ◽  
Nerve Growth ◽  
Phospholipase C Gamma

scholarly journals Nerve growth factor regulates endothelial cell survival and pathological retinal angiogenesis

2019 ◽  
Vol 23 (4) ◽  
pp. 2362-2371 ◽  
Author(s):  
Maria Troullinaki ◽  
Vasileia‐Ismini Alexaki ◽  
Ioannis Mitroulis ◽  
Anke Witt ◽  
Anne Klotzsche–von Ameln ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Survival ◽  
Nerve Growth ◽  
Endothelial Cell Survival ◽  
Retinal Angiogenesis

scholarly journals Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation.

1989 ◽  
Vol 8 (11) ◽  
pp. 3319-3325 ◽  
Author(s):  
B.B. Rudkin ◽  
P. Lazarovici ◽  
B.Z. Levi ◽  
Y. Abe ◽  
K. Fujita ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Nerve Growth

scholarly journals NF-κB Signaling Promotes Both Cell Survival and Neurite Process Formation in Nerve Growth Factor-Stimulated PC12 Cells

2000 ◽  
Vol 20 (20) ◽  
pp. 7556-7563 ◽  
Author(s):  
Erik D. Foehr ◽  
Xin Lin ◽  
Alison O'Mahony ◽  
Romas Geleziunas ◽  
Ralph A. Bradshaw ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Survival ◽  
Pc12 Cells ◽  
Nerve Growth ◽  
Process Formation
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