scholarly journals Gestational age-dependent gene expression profiling of ATP-binding cassette transporters in the healthy human placenta

2018 ◽  
Vol 23 (1) ◽  
pp. 610-618 ◽  
Author(s):  
Guinever E. Imperio ◽  
Mohsen Javam ◽  
Phetcharawan Lye ◽  
Andrea Constantinof ◽  
Caroline E. Dunk ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Gestational Age ◽  
Human Placenta ◽  
Expression Profiling ◽  
Atp Binding ◽  
Healthy Human ◽  
Atp Binding Cassette Transporters ◽  
Age Dependent ◽  
Atp Binding Cassette

scholarly journals Gene Expression Profiling of Transporters in the Solute Carrier and ATP-Binding Cassette Superfamilies in Human Eye Substructures

2013 ◽  
Vol 10 (2) ◽  
pp. 650-663 ◽  
Author(s):  
Amber Dahlin ◽  
Ethan Geier ◽  
Sophie L. Stocker ◽  
Cheryl D. Cropp ◽  
Elena Grigorenko ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Atp Binding ◽  
Human Eye ◽  
Solute Carrier ◽  
Atp Binding Cassette

scholarly journals Gene Expression Profiling Reveals Defined Functions of the ATP-Binding Cassette Transporter COMATOSE Late in Phase II of Germination

2007 ◽  
Vol 143 (4) ◽  
pp. 1669-1679 ◽  
Author(s):  
Esther Carrera ◽  
Tara Holman ◽  
Anne Medhurst ◽  
Wendy Peer ◽  
Heike Schmuths ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Phase Ii ◽  
Expression Profiling ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue

2004 ◽  
Vol 32 (3) ◽  
pp. 879-892 ◽  
Author(s):  
L Lundholm ◽  
S Moverare ◽  
KR Steffensen ◽  
M Nilsson ◽  
M Otsuki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Gene Expression Profiling ◽  
White Adipose Tissue ◽  
Expression Profiling ◽  
Liver X Receptor ◽  
Atp Binding ◽  
Mrna Levels ◽  
Ovariectomized Mice ◽  
Atp Binding Cassette

Estrogens reduce adipose tissue mass in both humans and animals. The molecular mechanisms for this effect are, however, not well characterized. We took a gene expression profiling approach to study the direct effects of estrogen on mouse white adipose tissue (WAT). Female ovariectomized mice were treated for 10, 24 and 48 h with 17beta-estradiol or vehicle. RNA was extracted from gonadal fat and hybridized to Affymetrix MG-U74Av2 arrays. 17beta-Estradiol was shown to decrease mRNA expression of liver X receptor (LXR) alpha after 10 h of treatment compared with the vehicle control. The expression of several LXRalpha target genes, such as sterol regulatory element-binding protein 1c, apolipoprotein E, phospholipid transfer protein, ATP-binding cassette A1 and ATP-binding cassette G1, was similarly decreased. We furthermore identified a 1.5 kb LXRalpha promoter fragment that is negatively regulated by estrogen. Several genes involved in lipogenesis and lipolysis were identified as novel targets that could mediate estrogenic effects on adipose tissue. Finally, we show that ERalpha is the main estrogen receptor expressed in mouse white adipose tissue (WAT) with mRNA levels several hundred times higher than those of ERbeta mRNA.

scholarly journals Role of Angiogenic Factors in Preeclampsia

2014 ◽  
Vol 9 (1) ◽  
pp. 71-73
Author(s):  
P Pradhan
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Disease Severity ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Expression Profiling ◽  
Placental Tissue ◽  
Angiogenic Factors ◽  
Angiogenic Proteins

Preeclampsia, the syndrome of hypertension, proteinuria, edema and hyperuricemia occurring during the last trimester of pregnancy remains one of the great mysteries. Recently gene expression profiling of placental tissue from healthy and preeclamptic women used to see which genes were up or down regulated in preeclamptic patients. Alterations in circulating angiogenic proteins correlated with disease severity, earlier onset of preeclampsia and birth of small for gestational age (SGA) fetus. These findings lend support to the hypothesis that circulating angiogenic proteins may have an important biological role in preeclampsia. DOI: http://dx.doi.org/10.3126/njog.v9i1.11194 NJOG 2014 Jan-Jun; 2(1):71-73

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