scholarly journals Supplementary choline attenuates olive oil lipid emulsion-induced enterocyte apoptosis through suppression of CELF1/AIF pathway

2017 ◽  
Vol 22 (3) ◽  
pp. 1562-1573 ◽  
Author(s):  
Jun-Kai Yan ◽  
Jie Zhu ◽  
Zi-Zhen Gong ◽  
Jie Wen ◽  
Yong-Tao Xiao ◽  
...  
Keyword(s):  
Olive Oil ◽  
Lipid Emulsion ◽  
Enterocyte Apoptosis

scholarly journals Olive Oil-Supplemented Lipid Emulsion Induces CELF1 Expression and Promotes Apoptosis in Caco-2 Cells

2017 ◽  
Vol 41 (2) ◽  
pp. 711-721 ◽  
Author(s):  
Jun-Kai Yan ◽  
Jie Zhu ◽  
Zi-Zhen Gong ◽  
Jie Wen ◽  
Yong-Tao Xiao ◽  
...  
Keyword(s):  
Olive Oil ◽  
Lipid Emulsion ◽  
In Vitro Model ◽  
Protein Translation ◽  
Dependent Manner ◽  
Enterocyte Apoptosis ◽  
Vitro Model ◽  
Induced Apoptosis ◽  
Apoptosis Inducing Factor

Background and Aims: Parenterally-administered lipid emulsion (LE) is a key cause of enterocyte apoptosis under total parenteral nutrition, yet the pathogenesis has not been fully understood. CUGBP, Elav-like family member 1 (CELF1) has been recently identified as a crucial modulator of apoptosis, and thus this study sought to investigate its role in the LE-induced apoptosis in vitro. Methods: Caco-2 cells were used as an in vitro model. The cells were treated with varying LEs derived from soybean oil, olive oil or fish oil, and changes in the apoptosis and CELF1 expression were assessed. Rescue study was performed using transient knockdown of CELF1 with specific siRNA prior to LE treatment. Regulation of CELF1 by LE treatment was studied using quantitative real-time PCR and Western blotting. Results: All the LEs up-regulated CELF1expression and induced apoptosis, but only olive oil-supplemented lipid emulsion (OOLE)-induced apoptosis was attenuated by depletion of CELF1. Up-regulation of apoptosis-inducing factor (AIF) was involved in OOLE-induced CELF1 dependent apoptosis. The protein expression of CELF1 was up-regulated by OOLE in a dose- and time-dependent manner, but the mRNA expression of CELF1 was unchanged. Analysis by polysomal profiling and nascent protein synthesis revealed that the regulation of CELF1 by OOLE treatment was mediated by directly accelerating its protein translation. Conclusion: OOLE-induces apoptosis in Caco-2 cells partially through up-regulation of CELF1.

scholarly journals Substitution of Standard Soybean Oil with Olive Oil-Based Lipid Emulsion in Parenteral Nutrition: Comparison of Vascular, Metabolic, and Inflammatory Effects

2011 ◽  
Vol 96 (10) ◽  
pp. 3207-3216 ◽  
Author(s):  
Joselita Siqueira ◽  
Dawn Smiley ◽  
Christopher Newton ◽  
Ngoc-Anh Le ◽  
Aidar R. Gosmanov ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Soybean Oil ◽  
Olive Oil ◽  
Lipid Emulsion

In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats

2000 ◽  
Vol 19 (1) ◽  
pp. 49-54 ◽  
Author(s):  
M. Moussa ◽  
J. Le Boucher ◽  
J. Garcia ◽  
J. Tkaczuk ◽  
J. Ragab ◽  
...  
Keyword(s):  
Olive Oil ◽  
Lipid Emulsion ◽  
Lymphocyte Activation ◽  
In Vivo Effects

O.08In vivo effects of olive oil-based lipid emulsion on lymphocyte activation in rats

1998 ◽  
Vol 17 ◽  
pp. 3
Author(s):  
M. Moussa ◽  
J. Garcia ◽  
J. Tkaczuk ◽  
J. Ragab ◽  
B. Périquet ◽  
...  
Keyword(s):  
Olive Oil ◽  
Lipid Emulsion ◽  
Lymphocyte Activation

scholarly journals Biological and Clinical Aspects of an Olive Oil-Based Lipid Emulsion—A Review

Nutrients ◽  
2018 ◽  
Vol 10 (6) ◽  
pp. 776 ◽  
Author(s):  
Wei Cai ◽  
Phillip Calder ◽  
Maria Cury-Boaventura ◽  
Elisabeth De Waele ◽  
Julie Jakubowski ◽  
...  
Keyword(s):  
Olive Oil ◽  
Lipid Emulsion ◽  
Clinical Aspects
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