scholarly journals Effects of an olive oil-based lipid emulsion (ClinOleic) versus LCT/MCT-based lipid emulsions upon the inflammatory markers of critically ill patients (EPICOS Study)

Critical Care ◽  
2010 ◽  
Vol 14 (Suppl 1) ◽  
pp. P562
Author(s):  
S Lima ◽  
A Pontes-Arruda ◽  
L Martins ◽  
M Pinheiro
Keyword(s):  
Olive Oil ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Inflammatory Markers ◽  
Lipid Emulsion ◽  
Lipid Emulsions

scholarly journals Rationale for using new lipid emulsions in parenteral nutrition and a review of the trials performed in adults

2009 ◽  
Vol 68 (3) ◽  
pp. 252-260 ◽  
Author(s):  
Philip C. Calder
Keyword(s):  
Parenteral Nutrition ◽  
Fish Oil ◽  
Immune Function ◽  
Olive Oil ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Adult Patients ◽  
Partial Replacement ◽  
Lipid Emulsions ◽  
Post Surgery

Lipids traditionally used in parenteral nutrition are based on n-6 fatty acid-rich vegetable oils such as soyabean oil. This practice may not be optimal because it may present an excessive supply of linoleic acid. Alternatives to the use of soyabean oil include its partial replacement by so-called medium-chain TAG (MCT), olive oil or fish oil, either alone or in combination. Lipid emulsions containing MCT are well established, but those containing olive oil and fish oil, although commercially available, are still undergoing trials in different patient groups. Emulsions containing olive oil or fish oil are well tolerated and without adverse effects in a wide range of adult patients. An olive oil–soyabean oil emulsion has been used in quite small studies in critically-ill patients and in patients with trauma or burns with little real evidence of advantage over soyabean oil or MCT–soyabean oil. Fish oil-containing lipid emulsions have been used in adult patients post surgery (mainly gastrointestinal). This approach has been associated with alterations in patterns of inflammatory mediators and in immune function and, in some studies, a reduction in the length of stay in the intensive care unit and in hospital. One study indicates that peri-operative administration of fish oil may be superior to post-operative administration. Fish oil has been used in critically-ill adults. Here, the influence on inflammatory processes, immune function and clinical end points is not clear, since there are too few studies and those that are available report contradictory findings. One important factor is the dose of fish oil required to influence clinical outcomes. Further studies that are properly designed and adequately powered are required in order to strengthen the evidence base relating to the use of lipid emulsions that include olive oil and fish oil in critically-ill patients and in patients post surgery.

scholarly journals Pragmatic Disease-Focused Checklist for Use During Rounding on Critically Ill Patients With COVID-19

2021 ◽  
pp. e1-e5
Author(s):  
Somnath Bose ◽  
Akiva Leibowitz
Keyword(s):  
Critically Ill ◽  
Family Communication ◽  
Critically Ill Patients ◽  
Inflammatory Markers ◽  
Medical Center ◽  
Academic Medical Center ◽  
Academic Medical ◽  
Ventilation Strategies ◽  
Novel Coronavirus ◽  
Existing Structure

The sudden surge in cases of novel coronavirus disease 2019 (COVID-19) has presented unprecedented challenges in the care of critically ill patients with the disease. A disease-focused checklist was developed to supplement and streamline the existing structure of rounds during a time of significant resource constraint. A total of 51 critical care consultants across multiple specialties at a tertiary academic medical center were surveyed regarding their preference for a structured checklist. Among the respondents, 82% were in favor of a disease-focused checklist. Mechanical ventilation parameters, rescue ventilation strategies, sedation regimens, inflammatory markers specific to COVID-19, and family communication were the elements most commonly identified as being important for inclusion in such a checklist.

scholarly journals The Effect of Using Olive Oil and Fish Oil Prophylactic Dressings on Heel Pressure Injury Development in Critically Ill Patients

2020 ◽  
Vol Volume 13 ◽  
pp. 59-65
Author(s):  
Zohreh Karimi ◽  
Ali Mousavizadeh ◽  
Hossein Rafiei ◽  
Naeem Abdi ◽  
Mohammad Behnammoghadam ◽  
...  
Keyword(s):  
Fish Oil ◽  
Olive Oil ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Pressure Injury

Effect of alternative intravenous lipid emulsion in clinical outcome in non-critically ill patients

2019 ◽  
Vol 33 ◽  
pp. 42-46
Author(s):  
Ennaliza Salazar ◽  
Palash Ghosh ◽  
Victor Tan ◽  
Tamara Pang ◽  
Bee Yen Poh ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Lipid Emulsion ◽  
Intravenous Lipid Emulsion

scholarly journals Early Tocilizumab Dosing is Associated with Improved Survival In Critically Ill Patients Infected With Sars-CoV-2

2020 ◽  
Author(s):  
Russell M. Petrak ◽  
Nicholas W. Van Hise ◽  
Nathan C. Skorodin ◽  
Robert M. Fliegelman ◽  
Vishnu Chundi ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Inflammatory Markers ◽  
Standard Of Care ◽  
Control Group ◽  
Cytokine Storm ◽  
Novel Coronavirus ◽  
Multi Center Study ◽  
Center Study

AbstractBackgroundSARS-CoV-2 is a novel coronavirus that has rapidly expanded to become a pandemic, resulting in millions of deaths worldwide. The cytokine storm is caused by the release of inflammatory agents and results in a physiologic disruption. Tocilizumab is an IL-6 receptor antagonist with the ability to suppress the cytokine storm in critically ill patients infected with SARS-CoV-2.MethodsThis was a multi-center study of patients infected with SARS-CoV-2, admitted between 3/13/20 and 4/16/20, requiring mechanical ventilation. Parameters that were evaluated included age, sex, race, usage of steroids, inflammatory markers, and comorbidities. Early dosing was defined as a tocilizumab dose administered prior to or within one (1) day of intubation. Late dosing was defined as a dose administered greater than one (1) day after intubation. A control group that was treated only with standard of care, and without tocilizumab, was utilized for comparison (untreated).FindingsWe studied 118 patients who required mechanical ventilation. Eighty-one (81) received tocilizumab, compared to 37 who were untreated. Early tocilizumab therapy was associated with a statistically significant decrease in mortality as compared to patients who were untreated (p=0.003). Dosing tocilizumab late was associated with an increased mortality compared to the untreated group (p=0.006).InterpretationEarly tocilizumab administration was associated with decreased mortality in critically ill SARS-Co-V-2 patients, but a potential detriment was suggested by dosing later in a patient’s course.FundingThis work did not receive outside funding or sponsorship.

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