scholarly journals The antineoplastic properties of FTY 720: evidence for the repurposing of fingolimod

2015 ◽  
Vol 19 (10) ◽  
pp. 2329-2340 ◽  
Author(s):  
Sathya Narayanan Patmanathan ◽  
Lee Fah Yap ◽  
Paul G. Murray ◽  
Ian C. Paterson
Keyword(s):  
Fty 720

scholarly journals PRETREATMENT WITH FTY-720 PROTECTS RENAL ALLOGRAFTS AGAINST PRESERVATION-REPERFUSION INJURY.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S127 ◽  
Author(s):  
Duska Dragun ◽  
Torsten Böhler ◽  
Johannes Waiser ◽  
HansHellmut Neumayer ◽  
Friedrich Luft ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Renal Allografts ◽  
Fty 720

Particle Size of Drug Nanocarriers Defines the Fate of Spinal Cord Injury’s Recovery

2021 ◽  
Author(s):  
Delaram Poormoghadam ◽  
Bita Rasoulian Shiadeh ◽  
Fereshte Azedi ◽  
Hani Tavakol ◽  
Seyed Mahdi Rezayat ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cell Membrane ◽  
Muscular Atrophy ◽  
Muscle Tone ◽  
Membrane Damage ◽  
Definitive Treatment ◽  
Detrusor Muscle ◽  
Cell Membrane Damage ◽  
Fty 720 ◽  
Cord Injury

Abstract Spinal cord injury (SCI) is a debilitating condition for which no definitive treatment has yet been identified. Noteworthy, it influences other tissues through inflammatory reactions and metabolic disturbance. Therefore, fingolimod (FTY-720) as an FDA-approved inflammatory modulator would be promising. In the present study, nanocarriers at two distinct monodisperse particle sizes of 60 (nF60) and 190 (nF190) nm were prepared.The neural stem cell (NSC) viability and LDH release were studied in the face of the nanocarriers and free FTY-720. Results indicated that nanocarriers and free FTY-720 enhanced NSC viability than the control group.However, nF190 significantly induced less cell membrane damage than nF60. Nanocarriers and free FTY-720 enhanced motor neuron recovery in SCI rats, while body weight and return to bladder reflux by nF190 was significantly higher than nF60 groups. Return to bladder reflux might be due to the role of FTY-720 in regulation of detrusor muscle tone and preservation of the integrity of vessels by acting on endothelial cells. Moreover,nF190 gained higher soleus muscle weight than the free drugs;probably decreasing pro-inflammatory cytokines in soleus diminish muscular atrophy in SCI rats.To sum thing up, larger nanacarrirs with less cell membrane damage seems to be more efficient than smaller ones to manage SCI.

FTY 720 prevents ischemic reperfusion damage in rat kidneys

2001 ◽  
Vol 33 (1-2) ◽  
pp. 857-859 ◽  
Author(s):  
P Troncoso ◽  
M Ortı́z ◽  
L Martı́nez ◽  
B.D Kahan
Keyword(s):  
Fty 720 ◽  
Ischemic Reperfusion ◽  
Reperfusion Damage ◽  
Rat Kidneys

scholarly journals The effect of FTY 720 on engraftment in a model of spontaneous allograft acceptance

2003 ◽  
Vol 16 (6) ◽  
pp. 383-390
Author(s):  
Takaaki Koshiba ◽  
Boudewijn Damme ◽  
Ping Ji ◽  
Hassan Sefrioui ◽  
Omer Rutgeerts ◽  
...  
Keyword(s):  
Fty 720

DOSE SELECTION BY PREDICTION OF HUMAN ORAL CLEARANCE OF FTY 720 USING INTERSPECIES SCALING

1999 ◽  
Vol 67 (7) ◽  
pp. S153 ◽  
Author(s):  
E Migoya ◽  
M Marino ◽  
S Choudhury ◽  
H-H Neumayer ◽  
R Brunkhorst ◽  
...  
Keyword(s):  
Interspecies Scaling ◽  
Oral Clearance ◽  
Dose Selection ◽  
Fty 720

PHARMACODYNAMICS OF FTY 720 IN RATS

1999 ◽  
Vol 67 (7) ◽  
pp. S62 ◽  
Author(s):  
K. Chiba ◽  
S. Nakayama ◽  
N. Arima ◽  
R. Kawai
Keyword(s):  
Fty 720
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