scholarly journals Establishment of a proteome profile and identification of molecular markers for mouse spermatogonial stem cells

2014 ◽  
Vol 19 (3) ◽  
pp. 521-534 ◽  
Author(s):  
Quan Zhou ◽  
Yueshuai Guo ◽  
Bo Zheng ◽  
Binbin Shao ◽  
Min Jiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Markers ◽  
Spermatogonial Stem Cells ◽  
Proteome Profile

scholarly journals Molecular markers of putative spermatogonial stem cells in the domestic cat

2016 ◽  
Vol 52 ◽  
pp. 177-186 ◽  
Author(s):  
SJ Bedford-Guaus ◽  
S Kim ◽  
L Mulero ◽  
JM Vaquero ◽  
C Morera ◽  
...  
Keyword(s):  
Stem Cells ◽  
Molecular Markers ◽  
Spermatogonial Stem Cells ◽  
Domestic Cat

scholarly journals Molecular Markers of Spermatogonial Stem Cells in the Domestic Cat

2012 ◽  
Vol 47 ◽  
pp. 256-260 ◽  
Author(s):  
LM Vansandt ◽  
BS Pukazhenthi ◽  
CL Keefer
Keyword(s):  
Stem Cells ◽  
Molecular Markers ◽  
Spermatogonial Stem Cells ◽  
Domestic Cat

scholarly journals Cellular Therapy via Spermatogonial Stem Cells for Treating Impaired Spermatogenesis, Non-Obstructive Azoospermia

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1779
Author(s):  
Nesma E. Abdelaal ◽  
Bereket Molla Tanga ◽  
Mai Abdelgawad ◽  
Sahar Allam ◽  
Mostafa Fathi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Male Infertility ◽  
Cellular Therapy ◽  
Antihypertensive Drugs ◽  
Testicular Biopsy ◽  
Testicular Tissue ◽  
Spermatogonial Stem Cells ◽  
Obstructive Azoospermia ◽  
Promising Alternative ◽  
Major Health Problem

Male infertility is a major health problem affecting about 8–12% of couples worldwide. Spermatogenesis starts in the early fetus and completes after puberty, passing through different stages. Male infertility can result from primary or congenital, acquired, or idiopathic causes. The absence of sperm in semen, or azoospermia, results from non-obstructive causes (pretesticular and testicular), and post-testicular obstructive causes. Several medications such as antihypertensive drugs, antidepressants, chemotherapy, and radiotherapy could lead to impaired spermatogenesis and lead to a non-obstructive azoospermia. Spermatogonial stem cells (SSCs) are the basis for spermatogenesis and fertility in men. SSCs are characterized by their capacity to maintain the self-renewal process and differentiation into spermatozoa throughout the male reproductive life and transmit genetic information to the next generation. SSCs originate from gonocytes in the postnatal testis, which originate from long-lived primordial germ cells during embryonic development. The treatment of infertility in males has a poor prognosis. However, SSCs are viewed as a promising alternative for the regeneration of the impaired or damaged spermatogenesis. SSC transplantation is a promising technique for male infertility treatment and restoration of spermatogenesis in the case of degenerative diseases such as cancer, radiotherapy, and chemotherapy. The process involves isolation of SSCs and cryopreservation from a testicular biopsy before starting cancer treatment, followed by intra-testicular stem cell transplantation. In general, treatment for male infertility, even with SSC transplantation, still has several obstacles. The efficiency of cryopreservation, exclusion of malignant cells contamination in cancer patients, and socio-cultural attitudes remain major challenges to the wider application of SSCs as alternatives. Furthermore, there are limitations in experience and knowledge regarding cryopreservation of SSCs. However, the level of infrastructure or availability of regulatory approval to process and preserve testicular tissue makes them tangible and accurate therapy options for male infertility caused by non-obstructive azoospermia, though in their infancy, at least to date.

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