scholarly journals Prognostic value of arterial stiffness measurements in cardiovascular disease, diabetes, and its complications: The potential role of sodium‐glucose co‐transporter‐2 inhibitors

2020 ◽  
Vol 22 (4) ◽  
pp. 562-571 ◽  
Author(s):  
Dimitrios Patoulias ◽  
Christodoulos Papadopoulos ◽  
Konstantinos Stavropoulos ◽  
Ioanna Zografou ◽  
Michael Doumas ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Arterial Stiffness ◽  
Prognostic Value ◽  
Potential Role

scholarly journals Arterial Stiffness Is Increased in Patients With Type 1 Diabetes Without Cardiovascular Disease: A potential role of low-grade inflammation

Diabetes Care ◽  
2012 ◽  
Vol 35 (5) ◽  
pp. 1083-1089 ◽  
Author(s):  
G. Llaurado ◽  
V. Ceperuelo-Mallafre ◽  
C. Vilardell ◽  
R. Simo ◽  
N. Freixenet ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Type 1 Diabetes ◽  
Arterial Stiffness ◽  
Potential Role ◽  
Low Grade ◽  
Low Grade Inflammation

scholarly journals Evaluation of serum ATX and LPA as potential diagnostic biomarkers in patients with pancreatic cancer

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jiang Chen ◽  
Hongyu Li ◽  
Wenda Xu ◽  
Xiaozhong Guo
Keyword(s):  
Pancreatic Cancer ◽  
Poor Prognosis ◽  
Prognostic Value ◽  
Potential Role ◽  
Early Stage ◽  
Serum Levels ◽  
Diagnostic Efficacy ◽  
Diagnostic Biomarkers ◽  
The Poor

Abstract Background Pancreatic cancer (PC) is a devastating disease that has a poor prognosis and a total 5-year survival rate of around 5%. The poor prognosis of PC is due in part to a lack of suitable biomarkers that can allow early diagnosis. The lysophospholipase autotaxin (ATX) and its product lysophosphatidic acid (LPA) play an essential role in disease progression in PC patients and are associated with increased morbidity in several types of cancer. In this study, we evaluated both the potential role of serum LPA and ATX as diagnostic markers in PC and their prognostic value for PC either alone or in combination with CA19-9. Methods ATX, LPA and CA19-9 levels were evaluated using ELISA of serum obtained from PC patients (n = 114) healthy volunteers (HVs: n = 120) and patients with benign pancreatic diseases (BPDs: n = 94). Results Serum levels of ATX, LPA and CA19-9 in PC patients were substantially higher than that for BPD patients or HVs (p < 0.001). The sensitivity of LPA in early phase PC was 91.74% and the specificity of ATX was 80%. The levels of ATX, LPA and CA19-9 were all substantially higher for early stage PC patients compared to levels in serum from BPD patients and HVs. The diagnostic efficacy of CA19-9 for PC was significantly enhanced by the addition of ATX and LPA (p = 0.0012). Conclusion Measurement of LPA and ATX levels together with CA19-9 levels can be used for early detection of PC and diagnosis of PC in general.

Excess all-cause mortality during COVID-19 outbreak: potential role of untreated cardiovascular disease

2020 ◽  
Author(s):  
Andrea SAGLIETTO ◽  
Fabrizio D'ASCENZO ◽  
Elena CAVARRETTA ◽  
Giacomo FRATI ◽  
Matteo ANSELMINO ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Potential Role ◽  
All Cause Mortality

scholarly journals Unexplained Anemia in the Elderly: Potential Role of Arterial Stiffness

2016 ◽  
Vol 7 ◽  
Author(s):  
David Montero ◽  
Candela Diaz-Cañestro ◽  
Andreas Flammer ◽  
Carsten Lundby
Keyword(s):  
Arterial Stiffness ◽  
Potential Role ◽  
The Elderly

scholarly journals Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction

2021 ◽  
Author(s):  
Rajeev Malhotra ◽  
Christopher J. Nicholson ◽  
Dongyu Wang ◽  
Vijeta Bhambhani ◽  
Samantha Paniagua ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Arterial Stiffness ◽  
Ejection Fraction ◽  
Vascular Calcification ◽  
Matrix Gla Protein ◽  
Preserved Ejection Fraction ◽  
Wild Type ◽  
Incident Heart Failure

Objective: Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction. MGP (matrix Gla protein) is implicated in vascular calcification in animal models, and circulating levels of the uncarboxylated, inactive form of MGP (ucMGP) are associated with cardiovascular disease-related and all-cause mortality in human studies. However, the role of MGP in arterial stiffness is uncertain. Approach and Results: We examined the association of ucMGP levels with vascular calcification, arterial stiffness including carotid-femoral pulse wave velocity (PWV), and incident heart failure in community-dwelling adults from the Framingham Heart Study. To further investigate the link between MGP and arterial stiffness, we compared aortic PWV in age- and sex-matched young (4-month-old) and aged (10-month-old) wild-type and Mgp +/− mice. Among 7066 adults, we observed significant associations between higher levels of ucMGP and measures of arterial stiffness, including higher PWV and pulse pressure. Longitudinal analyses demonstrated an association between higher ucMGP levels and future increases in systolic blood pressure and incident heart failure with preserved ejection fraction. Aortic PWV was increased in older, but not young, female Mgp +/− mice compared with wild-type mice, and this augmentation in PWV was associated with increased aortic elastin fiber fragmentation and collagen accumulation. Conclusions: This translational study demonstrates an association between ucMGP levels and arterial stiffness and future heart failure with preserved ejection fraction in a large observational study, findings that are substantiated by experimental studies showing that mice with Mgp heterozygosity develop arterial stiffness. Taken together, these complementary study designs suggest a potential role of therapeutically targeting MGP in heart failure with preserved ejection fraction.

scholarly journals Potential role of Anitschkow cells in cardiovascular disease in human and veterinary medicine: A review of the literature

2019 ◽  
Vol 48 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Elena Colombino ◽  
Ilaria Biasato ◽  
Elena Biasibetti ◽  
Alessandra Sereno ◽  
Laura Chiappino ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Veterinary Medicine ◽  
Potential Role ◽  
Review Of The Literature
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