scholarly journals The relationship of renal function to segmental vascular stiffness, ankle-brachial index, and peripheral artery disease

2018 ◽  
Vol 20 (6) ◽  
pp. 1027-1035 ◽  
Author(s):  
Yueh-Hung Lin ◽  
Kuo-Tzu Sung ◽  
Cheng-Ting Tsai ◽  
Pei-Chen Wu ◽  
Yau-Huei Lai ◽  
...  
Keyword(s):  
Renal Function ◽  
Peripheral Artery Disease ◽  
Ankle Brachial Index ◽  
Vascular Stiffness ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Relationship Of ◽  
The Relationship

scholarly journals Assessment of Serum Neopterin as a Biomarker in Peripheral Artery Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1911
Author(s):  
Agnieszka Zembron-Lacny ◽  
Wioletta Dziubek ◽  
Anna Tylutka ◽  
Eryk Wacka ◽  
Barbara Morawin ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Peripheral Artery Disease ◽  
Crucial Role ◽  
Reference Group ◽  
Ankle Brachial Index ◽  
Activated Macrophages ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Neopterin (NPT), a pyrazino-pyrimidine compound mainly produced by activated macrophages, has been regarded as a proinflammatory and proatherosclerotic agent. The study was designed to evaluate NPT level and its interaction with conventional peripheral artery disease (PAD) biomarkers and vascular regenerative potential in severe PAD. The study included 59 patients (females n = 17, males n = 42) aged 67.0 ± 8.2 years classified into two groups based on ankle-brachial index (ABI) measurements (ABI ≤ 0.9 n = 43, ABI ≤ 0.5 n = 16). A total of 60 subjects aged 70.4 ± 5.5 years (females n = 42, males n = 18) with ABI > 0.9 constituted a reference group. NPT concentration reached values above 10 nmol/L in patients with PAD, which differed significantly from reference group (8.15 ± 1.33 nmol/L). High levels of CRP > 5 mg/L, TC > 200 mg/dL as well as lipoproteins LDL > 100 mg/dL and non-HDL > 130 mg/dL were found in the same group, indicating the relationship between NPT and conventional atherogenic markers. The endothelial progenitor cells (EPCs) tended toward lower values in patients with ABI ≤ 0.5 when compared to reference group, and inversely correlated with NPT. These findings indicate a crucial role of NPT in atheromatous process and its usefulness in monitoring PAD severity. However, the role of NPT in chronic PAD needs further studies including relatively high number of subjects.

scholarly journals Hubungan Merokok dan Obesitas Sentral dengan Nilai Ankle-Brachial Index pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Maghfirah Savitri ◽  
Frans Wantania ◽  
Bisuk P. Sedli
Keyword(s):  
Peripheral Artery Disease ◽  
Health Care Providers ◽  
Significant Relationship ◽  
Central Obesity ◽  
Ankle Brachial Index ◽  
P Value ◽  
Care Providers ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Abstract: Peripheral artery disease (PAD) is commonly found in the community but it is hard to detect in primary health care providers. Smoking and central obersity are the major risk factors in the development of PAD. One non-invasive and cheap method in screening for PAD is determining the ankle-brachial index (ABI). This study was aimed to provide an overview of the relationship between ABI and smoking and central obesity among students of Faculty of Medicine, Sam Ratulangi University. This was an analytical study with a cross sectional design using the ABI results of the students. There were 73 students as subjects; 26 non-smokers with no central obesity (36%), 15 smokers (20%), 21 with central obesity (29%), and 11 smokers with central obesity (15%). The age range of subjects was 18-23 year olds (young adult age). The Fisher’s exact test analysis of the relationship between smoking and PAD obtained a p-value of 0.267 (p>=0.05) and of the relationship between central obesity and PAD obtained a p-value of 0.016 (p<=0.05). In conclusion, there was a significant relationship between central obesity and ABI, albeit there was no significant relationship between smoking and ABI.Keywords: peripheral artery disease, ankle-brachial index, smoking, central obesity. Abstrak: Penyakit arteri perifer (PAP) banyak ditemukan pada masyarakat tetapi sulit terdeteksi di layanan kesehatan primer. Merokok dan obesitas sentral ialah faktor risiko yang berperan penting dalam perkembangan PAP. Salah satu metode pemeriksaan non invasif, murah, dan mudah untuk mendeteksi PAP ialah dengan menentukan nilai Ankle-Brachial Index (ABI). Penelitian ini bertujuan untuk mengetahui gambaran ABI serta hubungan merokok dan obesitas sentral dengan PAP pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Jenis penelitian ialah analitik dengan desain potong lintang menggunakan hasil pemeriksaan ABI. Hasil penelitian mendapatkan 73 mahasiswa sebagai subyek; 26 yang tidak merokok dan tidak obes sentral (36%), 15 yang merokok (20%), 21 yang obes sentral (29%), dan 11 yang obes sentral dan merokok (15%). Kisaran usia sampel yaitu 18-23 tahun (usia dewasa muda). Hasil uji Fisher’s exact terhadap hubungan merokok dengan PAP didapatkan nilai p=0,269 (p>=0,05) dan untuk obesitas sentral dengan PAP didapatkan nilai p=0,016 (p<=0,05). Simpulan penelitian ini ialah terdapat hubungan bermakna antara obesitas dengan nilai ABI, tetapi tidak terdapat hubungan bermakna antara merokok dengan nilai ABI.Kata kunci: penyakit arteri perifer, ankle-brachial index, merokok, obesitas sentral

scholarly journals Hubungan Merokok dan Obesitas Sentral dengan Nilai Ankle-Brachial Index pada Mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi

e-CliniC ◽  
2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Maghfirah Savitri ◽  
Frans Wantania ◽  
Bisuk P. Sedli
Keyword(s):  
Peripheral Artery Disease ◽  
Health Care Providers ◽  
Significant Relationship ◽  
Central Obesity ◽  
Ankle Brachial Index ◽  
P Value ◽  
Care Providers ◽  
Peripheral Artery ◽  
Artery Disease ◽  
The Relationship

Abstract: Peripheral artery disease (PAD) is commonly found in the community but it is hard to detect in primary health care providers. Smoking and central obersity are the major risk factors in the development of PAD. One non-invasive and cheap method in screening for PAD is determining the ankle-brachial index (ABI). This study was aimed to provide an overview of the relationship between ABI and smoking and central obesity among students of Faculty of Medicine, Sam Ratulangi University. This was an analytical study with a cross sectional design using the ABI results of the students. There were 73 students as subjects; 26 non-smokers with no central obesity (36%), 15 smokers (20%), 21 with central obesity (29%), and 11 smokers with central obesity (15%). The age range of subjects was 18-23 year olds (young adult age). The Fisher’s exact test analysis of the relationship between smoking and PAD obtained a p-value of 0.267 (p>=0.05) and of the relationship between central obesity and PAD obtained a p-value of 0.016 (p<=0.05). In conclusion, there was a significant relationship between central obesity and ABI, albeit there was no significant relationship between smoking and ABI.Keywords: peripheral artery disease, ankle-brachial index, smoking, central obesity. Abstrak: Penyakit arteri perifer (PAP) banyak ditemukan pada masyarakat tetapi sulit terdeteksi di layanan kesehatan primer. Merokok dan obesitas sentral ialah faktor risiko yang berperan penting dalam perkembangan PAP. Salah satu metode pemeriksaan non invasif, murah, dan mudah untuk mendeteksi PAP ialah dengan menentukan nilai Ankle-Brachial Index (ABI). Penelitian ini bertujuan untuk mengetahui gambaran ABI serta hubungan merokok dan obesitas sentral dengan PAP pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Jenis penelitian ialah analitik dengan desain potong lintang menggunakan hasil pemeriksaan ABI. Hasil penelitian mendapatkan 73 mahasiswa sebagai subyek; 26 yang tidak merokok dan tidak obes sentral (36%), 15 yang merokok (20%), 21 yang obes sentral (29%), dan 11 yang obes sentral dan merokok (15%). Kisaran usia sampel yaitu 18-23 tahun (usia dewasa muda). Hasil uji Fisher’s exact terhadap hubungan merokok dengan PAP didapatkan nilai p=0,269 (p>=0,05) dan untuk obesitas sentral dengan PAP didapatkan nilai p=0,016 (p<=0,05). Simpulan penelitian ini ialah terdapat hubungan bermakna antara obesitas dengan nilai ABI, tetapi tidak terdapat hubungan bermakna antara merokok dengan nilai ABI.Kata kunci: penyakit arteri perifer, ankle-brachial index, merokok, obesitas sentral

scholarly journals Angiogenin—A Proposed Biomarker for Cardiovascular Disease—Is Not Associated With Long-Term Survival in Patients With Peripheral Artery Disease

Angiology ◽  
2021 ◽  
pp. 000331972110043
Author(s):  
Clemens Höbaus ◽  
Gerfried Pesau ◽  
Bernhard Zierfuss ◽  
Renate Koppensteiner ◽  
Gerit-Holger Schernthaner
Keyword(s):  
Peripheral Artery Disease ◽  
Cox Regression ◽  
Ankle Brachial Index ◽  
Limb Ischemia ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Peripheral Artery ◽  
Cross Sectional ◽  
Term Survival ◽  
Artery Disease

We evaluated angiogenin as a prospective biomarker in peripheral artery disease (PAD) patients with and without claudication symptoms. A pilot study suggested an elevation of angiogenin in critical limb ischemia. However, in PAD patients, the predictive value of angiogenin has not yet been evaluated. For this purpose, 342 patients with PAD (age: 69 ± 10 years, 34.5% women) were followed-up for 7 years in a cross-sectional study. Angiogenin was measured by enzyme-linked immunosorbent assay. All-cause and cardiovascular mortality were analyzed by Cox regression. Angiogenin levels were higher in men ( P = .001) and were associated with patient waist-to-hip ratio ( P < .001), fasting triglycerides ( P = .011), and inversely with estimated glomerular filtration rate ( P = .009). However, angiogenin showed no association with age, characteristics of diabetes, markers of lipid metabolism, or C-reactive protein. Angiogenin did not correlate with markers of angiogenesis such as vascular endothelial growth factor, angiopoietin-2, or tie-2. Furthermore, angiogenin was not associated with PAD Fontaine stages or with patient ankle-brachial index in addition to all-cause mortality (hazard ratio [HR] = 1.09 [95% CI: 0.89-1.34]) or cardiovascular morality (HR = 1.05 [0.82-1.35]). These results suggest that angiogenin does not provide further information regarding outcome prediction in patients with PAD.

scholarly journals Peripheral artery disease impairs myocardial perfusion through increasing pulse wave reflection: the Northern Shanghai study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
S Yu ◽  
J Teliewubai ◽  
X Fan ◽  
C Chi ◽  
H Ji ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Peripheral Artery Disease ◽  
Wave Reflection ◽  
Pulse Wave ◽  
Ankle Brachial Index ◽  
Community Dwelling ◽  
Peripheral Artery ◽  
Cardiac Damage ◽  
Pulse Wave Reflection ◽  
Artery Disease

Abstract Background Peripheral artery disease (PAD) is prevalent and substantially contributes to cardiovascular mortality particularly in the elderly, although the pathophysiological impact of PAD on heart itself still needs further investigation. In theory, PAD can increase pulse wave reflection which is an important determinant of subendocardial viability ratio (SEVR), a valuable estimate of myocardial perfusion as indicated by previous invasive studies. Thus, we hypothesize that PAD impairs myocardial perfusion through increasing pulse wave reflection. In this study, we aim to test this hypothesis in a large cohort from the Northern Shanghai Study. Methods A total of 2947 community-dwelling elderly Chinese (43.6% male, mean age: 71.3±5.9 years) were recruited. Ankle-brachial index were measured with the VP1000 device and used to diagnose PAD. Pulse wave reflection was estimated as aortic augmentation pressure (AP). Aortic BP, AP and SEVR were assessed by radial applanation tonometry. Multiple linear regression with SEVR and AP as dependent variable and PAD as independent variable, meanwhile adjusted for other covariates, were performed, respectively. Results 375 (12.7%) participants presented PAD. Compared to subjects without PAD, those with PAD showed significantly lower SEVR (126 vs. 132, P&lt;0.001) but higher AP (19 vs. 17 mmHg, P&lt;0.001). Multiple regression analysis revealed that both SEVR (regression coefficient [B] = −1.69, P=0.04, R2=0.61) and AP (B=1.19, P=0.04, R2=0.56) significantly associated with PAD, respectively. However, the association between SEVR and PAD was abolished when further adjusted for AP (B=−0.49, P=0.52). Similar results were obtained when inter-leg systolic BP difference was used to diagnose PAD. Conclusions PAD significantly and independently associates with myocardial perfusion; moreover, this association is mediated by increased pulse wave reflection. These findings provide a new dimension for understanding the pathophysiological mechanisms of cardiac damage of PAD. Funding Acknowledgement Type of funding source: None

scholarly journals Cholesterol Efflux Capacity Associates with the Ankle-Brachial Index but Not All-Cause Mortality in Patients with Peripheral Artery Disease

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1407
Author(s):  
Robert K. Clemens ◽  
Monika Hunjadi ◽  
Andreas Ritsch ◽  
Lucia Rohrer ◽  
Thomas O. Meier ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Cholesterol Efflux ◽  
Ankle Brachial Index ◽  
Mortality Rates ◽  
High Density Lipoproteins ◽  
Peripheral Artery ◽  
Cholesterol Efflux Capacity ◽  
Hdl Function ◽  
All Cause Mortality ◽  
Artery Disease

Background: Cholesterol efflux is an important mechanism by which high-density lipoproteins (HDLs) protect against cardiovascular disease. As peripheral artery disease (PAD) is associated with high mortality rates, mainly due to cardiovascular causes, we investigated whether cholesterol efflux capacity (CEC) of apolipoprotein B (apoB)-depleted plasma, a widely used surrogate of HDL function, may serve as a predictive marker for mortality in this patient population. Methods: In this prospective single-center study (median follow-up time: 9.3 years), apoB-containing lipoproteins were precipitated from plasma of 95 patients with PAD and incubated with J744-macrophages, which were loaded with radiolabeled cholesterol. CEC was defined as the fractional radiolabel released during 4 h of incubation. Results: Baseline CEC was lower in PAD patients that currently smoked (p = 0.015) and had a history of myocardial infarction (p = 0.011). Moreover, CEC showed a significant correlation with HDL-cholesterol (p = 0.003) and apolipoprotein A-I levels (p = 0.001) as well as the ankle-brachial index (ABI, p = 0.018). However, CEC did not differ between survivors and non-survivors. Neither revealed Kaplan–Meier and Cox regression analyses any significant association of CEC with all-cause mortality rates. Conclusion: Taken together, CEC is associated with ABI but does not predict all-cause mortality in patients with PAD.

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